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Enzyme Nomenclature
Information on EC 1.4.1.15 - lysine dehydrogenase
for references in articles please use BRENDA:EC1.4.1.15
Word Map on EC 1.4.1.15
- 1.4.1.15
- pomeroyi
-
6-dehydrogenase
-
silicibacter
- pipecolate
- saccharopine
- analysis
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.4.1.15
-
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RECOMMENDED NAME
GeneOntology No.
lysine dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
the pro-R hydrogen at the prochiral C-6 carbon of L-lysine is specifically abstracted and transferred to the pro-R position at C-4 of NAD+
-
L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Deamination
-
-
-
-
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)
-
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CAS REGISTRY NUMBER
COMMENTARY
68073-29-0
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
-
genomic organization and functional role of lysine catabolic pathways among prokaryotes, overview
physiological function
-
the enzyme is part of the lysine-to alpha-aminoadipic-delta-semialdehyde-pathway, that has a broad evolutionary importance in osmotic stress resistance
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
-
-
-
-
r
additional information
?
-
-
LysDH directly converts L-lysine to alpha-aminoadipic-delta-semialdehyde
-
-
-
4-hydroxylysine + NADP+
alpha-amino-gamma-hydroxyadipate-semialdehyde + NADPH
-
-
-
?
4-hydroxylysine + NADP+
alpha-amino-gamma-hydroxyadipate-semialdehyde + NADPH
-
-
-
?
5-hydroxylysine + NADP+
alpha-amino-delta-hydroxyadipate-semialdehyde + NADPH
-
-
-
?
5-hydroxylysine + NADP+
alpha-amino-delta-hydroxyadipate-semialdehyde + NADPH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
epsilon amino group is oxidatively deaminated to alpha-aminoadipate delta-semialdehyde, which is spontaneously converted into 1,2-didehydropiperidine-6-carboxylate
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
epsilon amino group is oxidatively deaminated to alpha-aminoadipate delta-semialdehyde, which is spontaneously converted into 1,2-didehydropiperidine-6-carboxylate, first step of lysine degradation
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
-
-
?
S-(2-aminoethyl)-L-cysteine + NADP+ + H2O
S-(2-oxoethyl)-L-cysteine + NADPH + NH3
-
-
-
?
S-(2-aminoethyl)-L-cysteine + NADP+ + H2O
S-(2-oxoethyl)-L-cysteine + NADPH + NH3
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
-
-
-
?
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
-
-
-
-
r
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
-
epsilon amino group is oxidatively deaminated to alpha-aminoadipate delta-semialdehyde, which is spontaneously converted into 1,2-didehydropiperidine-6-carboxylate, first step of lysine degradation
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
5,5-dithiobis(2-nitrobenzoate)
-
0.5 mM, 70% inhibition, 40% inhibition after preincubation with 10 mM L-lysine, 98.5% inhibition after preincubation with 1 mM NAD+
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
0.874 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the absence of cysteine; 11.96 micromol/min*l homogenate, in the presence of cysteine; 2.70 micromol/min*l homogenate, 3 months old baby girl with congenital lysine intolerance, in the presence of cysteine; 6.24 micromol/min*l homogenate, in the absence of cysteine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
9
-
oxidative deamination of S-(beta-aminoethyl)-cysteine, 5- and 4-hydroxylysine
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30 - 50
-
in the absence of lysine, approx. 50% activity after 10 min at 40°C
30 - 60
-
in the presence of 5 mM L-lysine, approx. 50% activity after 10 min at 55°C
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene lysdh is not upregulated under salt stress, in contrast to several other enzymes from the lysine-to-alpha-aminoadipic-delta-semialdehyde pathways, but is upregulated by addition of exogenous lysine
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
-
amperometric biosensor for L-lysine based on immobilized enzyme
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LINKS TO OTHER DATABASES (specific for EC-Number 1.4.1.15)
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