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Information on EC 1.3.1.114 - 3-dehydro-bile acid DELTA4,6-reductase

for references in articles please use BRENDA:EC1.3.1.114
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IUBMB Comments
Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7alpha-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7alpha-dehydration.
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The expected taxonomic range for this enzyme is: Clostridium scindens
Synonyms
BaiN, CLOSCI_00523, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
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(4)
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12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(3)
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3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
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(2)
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3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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