Ligand 3-oxochol-4-en-24-oyl-CoA
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Basic Ligand Information
Molecular Structure

C45H72N7O20P3S
3-oxochol-4-en-24-oyl-CoA
IQTDOBATHOETSQ-YEGOPCHWSA-N
7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
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7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+
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Substrate in Enzyme-catalyzed Reactions (2 results)
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3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
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7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
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Product in Enzyme-catalyzed Reactions (1 result)
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3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-DELTA4-cholenoic acid oxidoreductases
2008
Kang, D.; Ridlon, J.; Moore II, D.; Barnes, S.; Hylemon, P.
Biochim. Biophys. Acta
1781
16-25
Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704
2018
Harris, S.; Devendran, S.; Alves, J.; Mythen, S.; Hylemon, P.; Ridlon, J.
Biochim. Biophys. Acta
1863
276-283
Links to other databases for 3-oxochol-4-en-24-oyl-CoA