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EC Tree
IUBMB CommentsInvolved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase).
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
4-guanidinobutyraldehyde dehydrogenase, alpha-guanidinobutyraldehyde dehydrogenase, dehydrogenase, gamma-guanidinobutyraldehyde, gamma-guanidinobutyraldehyde dehydrogenase, GBAL dehydrogenase,
more
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4-guanidinobutyraldehyde dehydrogenase
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alpha-guanidinobutyraldehyde dehydrogenase
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dehydrogenase, gamma-guanidinobutyraldehyde
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gamma-guanidinobutyraldehyde dehydrogenase
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GBAL dehydrogenase
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4-guanidinobutanal + NAD+ + H2O = 4-guanidinobutanoate + NADH + 2 H+
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4-guanidinobutanal:NAD+ 1-oxidoreductase
Involved in the degradation of arginine in Pseudomonas putida (cf. EC 1.2.1.19 aminobutyraldehyde dehydrogenase).
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4-aminobutyraldehyde + NAD+
4-aminobutanoate + NADH
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
4-guanidinobutanal + NAD+

4-guanidinobutanoate + NADH
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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arginine catabolic pathway, involved in the degradation of arginine in Pseudomonas putida, cf. EC 1.2.1.19
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4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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specific for
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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arginine catabolic pathway, involved in the degradation of arginine in Pseudomonas putida, cf. EC 1.2.1.19
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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?
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4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
4-guanidinobutanal + NAD+

4-guanidinobutanoate + NADH
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arginine catabolic pathway, involved in the degradation of arginine in Pseudomonas putida, cf. EC 1.2.1.19
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?
4-guanidinobutanal + NAD+
4-guanidinobutanoate + NADH
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arginine catabolic pathway, involved in the degradation of arginine in Pseudomonas putida, cf. EC 1.2.1.19
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?
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additional information
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not NADP+
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NAD+

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NAD+
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highly specific for
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2-Carboxy-2'-hydroxy-5'-sulfoformazylbenzene
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zincon
diethyldithiocarbamate
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p-chloromercuribenzoate
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0.03
4-guanidinobutyraldehyde
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0.025
gamma-aminobutyraldehyde
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0.0034
gamma-guanidinobutyraldehyde
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0.084
NAD+

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cosubstrate gamma-guanidinobutyraldehyde
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7 - 10
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pH 7.0: about 20% of activity maximum, pH 10.0: about 80% of activity maximum
7.5 - 10
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pH 7.5: about 20% of activity maximum, pH 10: about 70% of activity maximum
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inducible by 2-ketoarginine
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brenda
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brenda
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brenda
inducible by L-arginine or its catabolic intermediates
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brenda
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brenda
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A0A7W5BAX2_9BURK
503
0
53856
TrEMBL
-
A0A6P1T8B1_9GAMM
505
0
54270
TrEMBL
-
A0A142N635_9PSED
497
0
53062
TrEMBL
-
A0A7W0BFT7_9PSED
497
0
53147
TrEMBL
-
M5CLM9_STEMA
498
0
53297
TrEMBL
-
A0A653B5G2_PSEOL
497
0
52991
TrEMBL
-
A0A0M9GFL9_9PSED
497
0
52951
TrEMBL
-
A0A7V9XHI1_9PSED
497
0
53022
TrEMBL
-
A0A7Y9Q1W4_9PSED
497
0
52935
TrEMBL
-
A0A7W7JFT7_PSEAC
497
0
53010
TrEMBL
-
A0A7W3JUA7_9MICO
504
0
53847
TrEMBL
-
A0A2S6NDC7_9RHIZ
499
0
53058
TrEMBL
-
A0A7Y9VBH2_9PSED
497
0
52866
TrEMBL
-
A0A7Y9VV46_9PSED
497
0
53163
TrEMBL
-
A0A7Y9V3B7_9PSED
497
0
52992
TrEMBL
-
A0A4P8HTK8_9BURK
496
0
52930
TrEMBL
-
A0A0M9GEN4_9PSED
497
0
53278
TrEMBL
-
A0A7W4TAV9_9PSED
497
0
52941
TrEMBL
-
A0A7Y7HX32_9BURK
493
0
52735
TrEMBL
-
A0A7Z0BR88_9PSED
497
0
53425
TrEMBL
-
A0A7V9XMX6_PSEOL
497
0
53056
TrEMBL
-
A0A7Y9L5A6_9BURK
492
0
52441
TrEMBL
-
A0A7W7XIV8_9PSED
497
0
52894
TrEMBL
-
A0A7X0BSR2_9PSED
497
0
53260
TrEMBL
-
A0A7X0CT47_9PSED
496
0
53405
TrEMBL
-
A0A7W9ZIM5_NOVIT
504
0
53944
TrEMBL
-
A0A7V9XWG0_9PSED
497
0
53073
TrEMBL
-
A0A7W5N3Q6_9PSED
496
0
53281
TrEMBL
-
A0A7W4T7E8_9PSED
497
0
52889
TrEMBL
-
A0A7Z0JUK1_PSEME
497
0
53031
TrEMBL
-
A0A7Z0AX34_9PSED
500
0
53787
TrEMBL
-
A0A7W7J5N4_9PSED
497
0
52823
TrEMBL
-
Q88CA3_PSEPK
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
497
0
53054
TrEMBL
-
A0A7W5DJE8_9GAMM
500
0
53597
TrEMBL
-
A0A7X0BKY1_9PSED
497
0
52713
TrEMBL
-
A0A7W8UAA5_9RHIZ
498
0
53997
TrEMBL
-
A0A7W7KLC0_9PSED
493
0
52193
TrEMBL
-
A0A379IMA0_PSEME
497
0
53147
TrEMBL
-
A0A7Y9VG71_9PSED
496
0
53338
TrEMBL
-
A0A1Q8YC11_9BURK
489
0
52426
TrEMBL
-
A0A7W7XIE9_9PSED
497
0
52817
TrEMBL
-
A0A7W5HT36_9PSED
497
0
52982
TrEMBL
-
A0A7W8TZ91_PSEME
497
0
53175
TrEMBL
-
A0A7W4T103_9PSED
496
0
53236
TrEMBL
-
A0A7W7KLQ6_9PSED
497
0
52926
TrEMBL
-
A0A7W4ZCD8_9GAMM
501
0
53573
TrEMBL
-
A0A0J7JAW8_9ALTE
505
0
53732
TrEMBL
-
A0A7W4TFM4_9PSED
497
0
52705
TrEMBL
-
A0A7Y9XNS5_9PSED
497
0
52860
TrEMBL
-
A0A7W8NI13_9BURK
498
0
52901
TrEMBL
-
A0A142NFS7_9PSED
496
0
53400
TrEMBL
-
A0A7W3LQS7_ACTNM
481
0
51571
TrEMBL
-
A0A7W5IRC8_9PSED
497
0
52983
TrEMBL
-
A0A7Y9W2M9_9PSED
496
0
53456
TrEMBL
-
A0A7W5P9T7_9GAMM
504
0
54010
TrEMBL
-
A0A7W9VLN1_PSEVI
497
0
52815
TrEMBL
-
A0A7W8YM15_9BURK
498
0
52861
TrEMBL
-
A0A7W7P515_9PSED
497
0
53127
TrEMBL
-
Q88MT7_PSEPK
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
474
0
50918
TrEMBL
-
A0A1A7C806_9BURK
492
0
52473
TrEMBL
-
A0A7W9XUV5_9PSED
497
0
53119
TrEMBL
-
Q9HTP2_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
497
0
53144
TrEMBL
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57000
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2 * 57000, SDS-PAGE
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dimer
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2 * 57000, SDS-PAGE
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10
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0°C, 24 h, 96% loss of activity
288292
5.7 - 8.6
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highest stability, 0°C, 24 h, 25% loss of activity
288292
9
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0°C, 24 h, 63% loss of activity
288292
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30
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10 min, 4% loss of activity
40
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15 min, pH 8.0, 70% loss of activity
60
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rapidly inactivated above
80
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10 min, complete inactivation
50

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15 min, pH 8.0, 100% loss of activity
50
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10 min, 62% loss of activity
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inactive in absence of 2-mercaptoethanol
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1-13 days, 4°C, 25-90% loss of activity, partial reactivation by dithiothreitol and 2-mercaptoethanol
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Jann, A.; Matsumoto, H.; Haas, D.
The fourth arginine catabolic pathway of Pseudomonas aeruginosa [published erratum appears in J Gen Microbiol 1988 Sep;134(Pt 9):2633]
J. Gen. Microbiol.
134
1043-1053
1988
Pseudomonas aeruginosa
brenda
Yorifuji, T.; Koike, K.; Sakurai, T.; Yokoyama, K.
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenase for arginine degradation in Pseudomonas putida
Agric. Biol. Chem.
50
2009-2016
1986
Pseudomonas putida
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brenda
Vanderbilt, A.S.; Gaby, N.S.; Rodwell, V.W.
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida
J. Biol. Chem.
250
5322-5329
1975
Pseudomonas putida
brenda
Matsuda, H.; Suzuki, Y.
gamma-Guanidinobutyraldehyde dehydrogenase of Vicia faba leaves
Plant Physiol.
76
654-657
1984
Vicia faba
brenda
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