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Literature summary for 1.2.1.54 extracted from
- gamma-Guanidinobutyraldehyde dehydrogenase of Vicia faba leaves (1984), Plant Physiol., 76, 654-657.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Carboxy-2'-hydroxy-5'-sulfoformazylbenzene | zincon | Vicia faba |  |
| diethyldithiocarbamate | - |
Vicia faba | |
| Ferron | - |
Vicia faba | |
| N-ethylmaleimide | - |
Vicia faba | |
| o-phenanthroline | - |
Vicia faba | |
| p-chloromercuribenzoate | - |
Vicia faba | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
gamma-guanidinobutyraldehyde | - |
Vicia faba | |
| 0.025 | - |
gamma-aminobutyraldehyde | - |
Vicia faba | |
| 0.084 | - |
NAD+ | cosubstrate gamma-guanidinobutyraldehyde | Vicia faba | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 83000 | - |
gel filtration | Vicia faba |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vicia faba | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Vicia faba |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Vicia faba | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 49.73 | - |
- |
Vicia faba |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 1-13 days, 4°C, 25-90% loss of activity, partial reactivation by dithiothreitol and 2-mercaptoethanol | Vicia faba |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-aminobutyraldehyde + NAD+ | - |
Vicia faba | 4-aminobutanoate + NADH | - |
? | |
| 4-guanidinobutanal + NAD+ | - |
Vicia faba | 4-guanidinobutanoate + NADH | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Vicia faba |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
- |
20 | stable | Vicia faba |
| 30 | - |
10 min, 4% loss of activity | Vicia faba |
| 50 | - |
10 min, 62% loss of activity | Vicia faba |
| 60 | - |
rapidly inactivated above | Vicia faba |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Vicia faba |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 10 | pH 7.5: about 20% of activity maximum, pH 10: about 70% of activity maximum | Vicia faba |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.7 | 8.6 | highest stability, 0°C, 24 h, 25% loss of activity | Vicia faba |
| 9 | - |
0°C, 24 h, 63% loss of activity | Vicia faba |
| 10 | - |
0°C, 24 h, 96% loss of activity | Vicia faba |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not NADP+ | Vicia faba | |
| NAD+ | - |
Vicia faba | |
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Release 2023.1 (January 2023)
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