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acetaldehyde + NAD+ + H2O
acetate + NADH + H+
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
betaine + NADH
betaine aldehyde + NAD+ + H2O
-
Substrates: isozyme A 139% of activity with glycolate, isozyme B, 76%
Products: glucono-delta-lactone is not used as substrate
?
DL-glyceraldehyde + NAD+ + H2O
2,3-dihydroxypropanoic acid + NADH + H+
-
Substrates: -
Products: -
?
formate + NADH
methanal + NAD+
-
Substrates: isozyme A, 163% of activity with glycolate
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
glycolaldehyde + NAD+ + H2O
glycolate + NADH + 2 H+
Substrates: -
Products: -
?
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
glyoxylate + NADH
glyoxal + NAD+
-
Substrates: isozyme A, 417% of activity with glycolate, isozyme B 714%, isozyme C 150%
Products: -
?
hydroxypyruvate + NAD+ + H2O
?
-
Substrates: -
Products: -
?
malonate + NADH
malonic semialdehyde + NAD+ + H2O
-
Substrates: isozyme A, 83% of activity with glycolate
Products: -
?
oxalate + NADH
glyoxylate + NAD+
propionaldehyde + NAD+ + H2O
propionate + NADH
succinate + NADH
succinic semialdehyde + NAD+ + H2O
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
Substrates: -
Products: -
r
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
Substrates: -
Products: -
r
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
Substrates: reverse reaction, isozyme A, 188% of activity with glycolate, isozyme B, 112%, isozyme C, 74%
Products: -
r
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
-
Substrates: reverse reaction, isozyme A, 188% of activity with glycolate, isozyme B, 112%, isozyme C, 74%
Products: -
r
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
Substrates: good substrate for oxidizing reaction, bad substrate for reducing reaction, very low activity with NADP+
Products: -
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
Substrates: good substrate for oxidizing reaction, bad substrate for reducing reaction, very low activity with NADP+
Products: -
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
Substrates: isozyme A, 195% of activity with glycolate in reverse reaction
Products: -
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
-
Substrates: isozyme A, 195% of activity with glycolate in reverse reaction
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: oxidation of glycolaldehyde
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
Alcaligenes viscolactis
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: oxidation of glycolaldehyde
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: oxidation of glycolaldehyde
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: relative activity of isozymes A, B and C in wild-type strain in%: 75.2/19.7/5.2
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: relative activity of isozymes A, B and C in wild-type strain in%: 75.2/19.7/5.2
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: oxidation of glycolaldehyde
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: oxidation of glycolaldehyde
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
Protaminobacter alboflavus
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
r
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: reduction of glycolate
Products: -
ir
glycolaldehyde + NAD+ + H2O
glycolate + NADH
-
Substrates: -
Products: -
ir
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
-
Substrates: 87.4% of activity with NAD+, 595% of activity with NADH in reverse reaction
Products: -
r
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
-
Substrates: 87.4% of activity with NAD+, 595% of activity with NADH in reverse reaction
Products: -
r
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
-
Substrates: -
Products: -
?
glycolaldehyde + NADP+ + H2O
glycolate + NADPH + H+
-
Substrates: -
Products: -
?
oxalate + NADH
glyoxylate + NAD+
-
Substrates: isozyme A, 167% of activity with glycolate, isozyme B, 71%
Products: -
?
oxalate + NADH
glyoxylate + NAD+
-
Substrates: isozyme A, 167% of activity with glycolate, isozyme B, 71%
Products: -
?
propionaldehyde + NAD+ + H2O
propionate + NADH
-
Substrates: -
Products: -
?
propionaldehyde + NAD+ + H2O
propionate + NADH
-
Substrates: -
Products: -
?
succinate + NADH
succinic semialdehyde + NAD+ + H2O
-
Substrates: isozyme A, 146% of activity with glycolate, isozyme B 6%
Products: -
?
succinate + NADH
succinic semialdehyde + NAD+ + H2O
-
Substrates: isozyme A, 146% of activity with glycolate, isozyme B 6%
Products: -
?
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Al3+
-
1 mM, isozyme A, 26% inhibition
As3+
-
1 mM, isozyme A, 42% inhibition, isozyme B, 11% inhibition, isozyme C, 55% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Ca2+
-
1 mM, isozyme A, 42% inhibition, isozyme B, 32% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Co2+
-
1 mM, isozyme A, 71% inhibition, isozyme B, 51% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
glycolaldehyde
-
substrate inhibition
glycolate
-
substrate inhibition
Mg2+
-
1 mM, isozyme A, 33% inhibition, isozyme B, 54% inhibition, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
Mn2+
-
1 mM, isozyme A, 20% inhibition, isozyme C, 44% inhibition
monoiodoacetate
-
1 mM, isozymes A, 83% inhibition, isozyme C, 100% inhibition
MoO22-
-
1 mM, complete inhibition of isozyme A from pyridoxine auxotroph mutant strain WG3
p-chloromercuribenzoate
-
0.1 mM, 36% inhibition
pyridoxal
-
0.01 mM, 40% inhibition of total enzyme activity in cell extracts
pyridoxamine
-
approx. 0.1 mM, 22% inhibition of isozyme A
pyridoxamine phosphate
-
approx. 0.1 mM, 23% inhibition of isozyme A
pyridoxine
-
approx. 0.1 mM, 33% inhibition of isozyme C, 0.39 mM, 50% inhibition
pyridoxine phosphate
-
approx. 0.1 mM, 23% inhibition of isozyme C
Zn2+
-
1 mM, isozyme A, 30% inhibition
Fe2+
-
1 mM, 63% inhibition
Fe2+
-
1 mM, isozyme A, 18% inhibition
HgCl2
-
-
HgCl2
-
1 mM, complete inhibition of isozymes A, B, and C
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0.01
-
enzyme activity in crude extracts of temperature sensitive strain JA-104 at 42°C
0.042
Alcaligenes viscolactis
-
glycolate reduction in cell extracts
0.1
-
glycolate reduction in cell extracts
0.105
-
glycolate reduction in cell extracts
0.11
-
glycolate reduction in cell extracts
0.13
-
enzyme activity in crude extracts of strain 1 grown on casein hydrosylate
0.136
-
glycolate reduction in cell extracts
0.145
-
enzyme activity in crude extracts of wild-type strain G1
0.165
-
enzyme activity in crude extracts of wild-type strain G3
0.187
-
glycolate reduction in cell extracts
0.21
-
enzyme activity in crude extracts of strain 1 grown on fucose
0.23
-
glycolate reduction in cell extracts
0.262
-
glycolaldehyde oxidation in cell extracts
0.267
-
glycolaldehyde oxidation in cell extracts
0.3
-
glycoldehyde oxidation in cell extracts
0.325
-
glycolaldehyde oxidation in cell extracts
0.34
-
enzyme activity in crude extracts of strain JA-102 grown on ethylene glycol
0.362
-
glycolate reduction in cell extracts
0.56
-
enzyme activity in crude extracts of ethylene glycol positive mutant strain EG3
0.825
Protaminobacter alboflavus
-
glycolate reduction in cell extracts
0.927
-
glycolate reduction in cell extracts
1.079
-
glycolaldehyde oxidation in cell extracts
1.549
-
strain IFO 3009, glycolate reduction in cell extracts
1.65
-
glycolaldehyde oxidation in cell extracts
10.39
-
glycolaldehyde oxidation in cell extracts
6.38
-
isozyme A from pyridoxine auxotroph strain WG3
0.12
-
glycolate reduction in cell extracts
0.12
-
enzyme activity in crude extracts of temperature sensitive strain JA-104 at 30°C
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Caballero, E.; Baldoma, L.; Ros, J.; Boronat, A.; Aguilar, J.
Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli
J. Biol. Chem.
258
7788-7792
1983
Escherichia coli
brenda
Boronat, A.; Caballero, E.; Aguilar, J.
Experimental evolution of a metabolic pathway for ethylene glycol utilization by Escherichia coli
J. Bacteriol.
153
134-139
1983
Escherichia coli
brenda
Morita, H.; Yamamoto, K.; Tani, Y.; Ogata, K.; Yamada, H.
Glycoladehyde dehydrogenase, an enzyme related to vitamin B6 biosynthesis, from Bacillus subtilis
Agric. Biol. Chem.
43
317-323
1979
Bacillus subtilis, Bacillus subtilis IFO 3007
-
brenda
Morita, H.; Nishimura, T.; Tani, Y.; Ogata, K.; Yamada, H.
Bacterial distribution of glycolaldehyde dehydrogenase in relation to vitamin B6 biosynthesis
Agric. Biol. Chem.
43
185-186
1979
Agrobacterium tumefaciens, Alcaligenes viscolactis, Bacillus licheniformis, Bacillus subtilis, Corynebacterium glutamicum, Flavobacterium sp., Klebsiella aerogenes, Klebsiella pneumoniae, Micrococcus luteus, Pimelobacter simplex, Priestia megaterium, Protaminobacter alboflavus, Proteus vulgaris, Pseudomonas fluorescens, Rhodococcus equi, Salmonella enterica subsp. enterica serovar Typhimurium, Staphylococcus aureus
-
brenda
Morita, H.; Tani, Y.; Ogata, K.; Yamada, H.
Further characterization of glycolaldehyde dehydrogenase isozymes from Escherichia coli B involvement in vitamin B6 biosynthesis
Agric. Biol. Chem.
42
2077-2081
1978
Escherichia coli, Escherichia coli B WG1
-
brenda
Morita, H.; Tani, Y.; Ogata, K.
Control of glycolaldehyde dehydrogenase in vitamin B6 biosynthesis in Escherichia coli B
Agric. Biol. Chem.
42
69-73
1978
Escherichia coli, Escherichia coli B WG1
-
brenda
Tani, Y.; Morita, H.; Nishise, H.; Ogata, K.
Separation and characterization of glycolaldehyde dehydrogenase isozymes in Escherichia coli B
Agric. Biol. Chem.
42
63-68
1978
Escherichia coli, Escherichia coli B WG1
-
brenda
Missihoun, T.; Kotchoni, S.
Aldehyde dehydrogenases and the hypothesis of a glycolaldehyde shunt pathway of photorespiration
Plant Signal. Behav.
13
e1449544
2018
Arabidopsis thaliana (Q8W033), Arabidopsis thaliana (Q9SYG7)
brenda