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Literature summary for 1.2.1.21 extracted from

  • Morita, H.; Tani, Y.; Ogata, K.
    Control of glycolaldehyde dehydrogenase in vitamin B6 biosynthesis in Escherichia coli B (1978), Agric. Biol. Chem., 42, 69-73.
No PubMed abstract available
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Activating Compound

Activating Compound Comment Organism Structure
pyridoxal approx. 0.1 mM, 1.4fold increase in activity of isozyme A Escherichia coli
pyridoxal 5'-phosphate approx. 0.1 mM, 1.5fold increase in activity of isozyme B Escherichia coli
pyridoxine 0.1 mM, 1.5fold increase in activity of isozyme B Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal 0.01 mM, 40% inhibition of total enzyme activity in cell extracts Escherichia coli
pyridoxamine approx. 0.1 mM, 22% inhibition of isozyme A Escherichia coli
pyridoxamine phosphate approx. 0.1 mM, 23% inhibition of isozyme A Escherichia coli
pyridoxine approx. 0.1 mM, 33% inhibition of isozyme C, 0.39 mM, 50% inhibition Escherichia coli
pyridoxine phosphate approx. 0.1 mM, 23% inhibition of isozyme C Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B WG1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycolaldehyde + NAD+ + H2O
-
 Escherichia coli glycolate + NADH
-
 ?
glycolaldehyde + NAD+ + H2O
-
 Escherichia coli B WG1 glycolate + NADH
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.33
-
 pyridoxine inhibition of isozyme C Escherichia coli