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Information on EC 1.14.19.6 - acyl-CoA (9+3)-desaturase
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EC Tree
1.14.19.6 acyl-CoA (9+3)-desaturaseIUBMB Comments
This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Delta10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor .
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Word Map
- 1.14.19.6
-
linoleic
-
desaturation
-
oleic
-
polyunsaturated
- synechocystis
-
alpha-linolenic
- nutrition
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
2
+
+
2
=
+
2
+
2
Synonyms
delta 12 desaturase, fad-2, delta-12 fatty acid desaturase, le-fad2, delta 12 fatty acid desaturases, ptfad2, klfad2, delta12-fad, egfad2, csfad2a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acyl-CoA (9+3)-desaturase
-
-
-
-
delta-12 fatty acid desaturase
delta-12 fatty acid desaturase 2
DELTA12 desaturase
DELTA12 FAD
DELTA12 fatty acid desaturase
DELTA12 oleate hydroxylase
-
shows DELTA12 desaturase activities on 16C and 18C monounsaturated fatty acids
DELTA12-acyl-lipid desaturase
DELTA12-desaturase
DELTA12-desaturase system
DELTA12-FAD
DELTA12-fatty acid desaturase
DELTA12des
DELTA12DS
Des12
DesA
egFAD2
FAD2
FAD2-2
fatty acid desaturase-2
KlFAD2
LKFAD15
microsomal delta-12 oleate desaturase
microsomal omega-6 fatty acid desaturase
oleoyl-DELTA12 desaturase
oleoyl-DELTA12/linoleoyl-DELTA3 desaturase
seed-specific delta-12 fatty acid desaturase 2
DELTA12DS
bifunctional enzyme with strong DELTA12 and low DELTA15 desaturase activities
DELTA12DS
bifunctional enzyme with strong DELTA12 and low DELTA15 desaturase activities
-
DELTA12DS
bifunctional enzyme with strong DELTA12 and low DELTA15 desaturase activities
-
DesA
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
(1)
-
-
-
palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
(2)
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (12,13 cis-dehydrogenating)
This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Delta10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor [4].
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CAS REGISTRY NUMBER
COMMENTARY
84628-81-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
9-hexadecenoyl-CoA + reduced acceptor + O2
9,12-hexadecadienoyl-CoA + acceptor + H2O
low activity
-
-
?
9-octadecenoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + H2O
-
-
-
?
acyl-CoA + reduced acceptor + O2
DELTA12-acyl-CoA + acceptor + H2O
-
-
-
?
cis-7-hexadecenoic acid + reduced acceptor + O2
cis,cis-7,10-hexadecadienoic acid + acceptor + H2O
-
5.2% desaturation
-
-
?
cis-9-heptadecenoic acid + reduced acceptor + O2
cis,cis-9,12-heptadecadienoic acid + acceptor + H2O
-
22.3% desaturation
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
cis-9-icosenoic acid + reduced acceptor + O2
cis,cis-11,14-icosadienoic acid + acceptor + H2O
-
4.1% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
eicosenoic acid + reduced acceptor + O2
20:2DELTA11,14 + acceptor + H2O
62% conversion
-
-
?
heptadecyloleic acid + reduced acceptor + O2
C17:2DELTA9,12 + acceptor + H2O
-
-
-
?
myristoleic acid + reduced acceptor + O2
C14:2DELTA9,12 + acceptor + H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
pentadecyloleic acid + reduced acceptor + O2
C15:2DELTA9,12 + acceptor + H2O + acceptor
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(10Z)-nonadec-10-enoic acid + reduced acceptor + O2
(10Z,13Z)-nonadeca-10,13-dienoic acid + acceptor + H2O
-
-
-
-
?
(Z)-9-tetradecenoic acid + ?
tetradec-9,12-dienoic acid
-
biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a DELTA12 desaturase
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
-
-
-
?
5,8,11,14-eicosatetraenoyl-CoA + reduced acceptor + O2
5,8,11,14,17-eicosadecapentaenoyl-CoA + acceptor + H2O
-
-
-
?
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
-
-
-
?
6,9,12-octadecatrienoyl-CoA + reduced acceptor + O2
6,9,12,15-octadecatetraenoyl-CoA + acceptor + H2O
-
-
-
?
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
high activity
-
-
?
9,12-octadecadienoyl-CoA + reduced acceptor + O2
9,12,15-octadecatrienoyl-CoA + acceptor + H2O
high activity
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
-
14.7% desaturation
-
-
?
cis-9-hexadecenoic acid + reduced acceptor + O2
cis,cis-9,12-hexadecadienoic acid + acceptor + H2O
-
70.3% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
PtFAD2 is involved in the biosynthesis of eicosapentaenoic acid
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
20.6% desaturation
-
-
?
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
cis-9-octadecenoic acid is the most efficient substrate for PtFAD2, 50.3% desaturation
-
-
?
oleic acid + ?
linoleic acid + ?
-
DELTA12-desaturase mutant shows delayed spore germination, a twofold reduction in growth, a reduced level of conidiation and complete loss of sclerotial development, compared with the wild-type enzyme
-
-
?
oleic acid + ?
linoleic acid + ?
linoleic acid was detectable when expressing Fm2 in DELTA12 desaturase knockout Yarrowia lipolytica
-
-
?
oleic acid + ?
linoleic acid + ?
expression in Saccharomyces cerevisiae leads to endogenous production of linoleic acid
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
best substrate with 72% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
best substrate with 23% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
FAD2 introduces a double bond in position DELTA12 in oleic acid (18:1) to form linoleic acid (18:2 n-6)
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
specific substrate
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
specific substrate
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
best substrate with 63.3% conversion
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + acceptor + H2O
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + alpha-linolenic acid + acceptor + H2O
-
-
-
-
?
oleic acid + reduced acceptor + O2
linoleic acid + alpha-linolenic acid + acceptor + H2O
-
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
oleoyl-CoA + 2 reduced acceptor + O2 + 2 H+
linoleoyl-CoA + 2 acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + 2 reduced acceptor + O2 + 2 H+
linoleoyl-CoA + 2 acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
9,12-octadecadienoyl-CoA + acceptor + 2 H2O
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
octadec-9,11-dienoyl-CoA + acceptor + 2 H2O
-
-
-
-
?
oleoyl-CoA + reduced acceptor + O2
octadec-9,11-dienoyl-CoA + acceptor + 2 H2O
-
the DELTA12 desaturase provides the key step for the cockroach to become nutritionally independent of dietary lipid and to synthesize eicosanoids de novo
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
43% conversion
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
-
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
4.1% conversion
-
-
?
palmitoleic acid + reduced acceptor + O2
(9Z,12Z)-hexadeca-9,12-dienoic acid + acceptor + H2O
-
26.7% conversion
-
-
?
stearolic acid + reduced acceptor + O2
trans-12-octadecen-9-ynoic acid + acceptor + H2O
-
4.8% conversion
-
-
?
stearolic acid + reduced acceptor + O2
trans-12-octadecen-9-ynoic acid + acceptor + H2O
-
35% conversion
-
-
?
additional information
?
-
-
oxygen availability alone can regulate de novo DELTA12-desaturase synthesis in Acanthamoeba castellanii and oxygen can limit the activity of preexisting DELTA12-desaturase
-
-
?
additional information
?
-
-
the main transition in fatty acid metabolism of Acanthamoeba castellanii during batch growth appears to be primarily related to a rapid decline in DELTA12-desaturase activity after 24 h. The resultant large growth-dependent changes in the degree of fatty acid unsaturation would be expected to affect the physical state and/or fluidity of membranes, and may be related to many of the distinctive physiological and biochemical characteristics displayed by Acanthamoeba castellanii in different stages of batch growth
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a processive bifunctional oleoyl-DELTA12/linoleoyl-DELTA3 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
one of two membrane-bound fatty acid desaturases occurring in Aspergillus nidulans, a strictly monofunctional oleoyl-DELTA12 desaturase, substrate specificity of the recombinant enzyme, overview
-
-
?
additional information
?
-
the enzyme can also catalyze DELTA15 desaturation
-
-
?
additional information
?
-
recombinantly expressed enzyme CSFAD2A is a DELTA12 desaturase and has DELTAx+3 activity
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
the enzyme is a bifunctional fatty acid desaturase with both high DELTA12 desaturase activity and unusual DELTA15 desaturase activities
-
-
?
additional information
?
-
-
the DELTA12-desaturase enzymatic complex shows a preference towards oleoyl-CoA versus elaidoyl-CoA. Study of substrate specificity of the DELTA12 desaturase system is difficult due to the involvement of numerous enzymes. At least two activities are involved: in a first step, acyl CoA synthetase catalyzes the formation of oleoyl-CoA from olic acid and CoA, then oleoyl-CoA is desaturated into linoleoyl-CoA. No desaturation occurs when CoA is absent in the reaction medium
-
-
?
additional information
?
-
-
the DELTA12-desaturase enzymatic complex shows a preference towards oleoyl-CoA versus elaidoyl-CoA. Study of substrate specificity of the DELTA12 desaturase system is difficult due to the involvement of numerous enzymes. At least two activities are involved: in a first step, acyl CoA synthetase catalyzes the formation of oleoyl-CoA from olic acid and CoA, then oleoyl-CoA is desaturated into linoleoyl-CoA. No desaturation occurs when CoA is absent in the reaction medium
-
-
?
additional information
?
-
-
PtFAD6 is involved in the biosynthesis of hexadecantrienic acid
-
-
?
additional information
?
-
-
no activity with cis-13-docosenoic acid
-
-
?
additional information
?
-
-
synergistic effect of high-light and low temperature on cell growth of the DELTA12 fatty acid desaturase mutant
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
-
no activity with myristoleic acid palmitoleic acid, heptadecenoic acid, elaidic acid, linolenic acid, dihomo-gamma-linolenic acid, arachidonic acid, or docosatetraenoic acid
-
-
?
additional information
?
-
-
the enzyme has dual specificities of a DELTA12-fatty acid desaturase and a v+3-fatty acid desaturase
-
-
?
additional information
?
-
gene Ssd12 encodes a DELTA12-FAD, which can convert 16:1 and 18:1 into 16:2 and 18:2 fatty acids, substrate specificity, overview
-
-
?
additional information
?
-
-
gene Ssd12 encodes a DELTA12-FAD, which can convert 16:1 and 18:1 into 16:2 and 18:2 fatty acids, substrate specificity, overview
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(Z)-9-tetradecenoic acid + ?
tetradec-9,12-dienoic acid
-
biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a DELTA12 desaturase
-
-
?
1-oleoyl-2-acyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-linoleoyl-2-acyl-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
cis-9-octadecenoic acid + reduced acceptor + O2
cis,cis-9,12-octadecadienoic acid + acceptor + 2 H2O
-
PtFAD2 is involved in the biosynthesis of eicosapentaenoic acid
-
-
?
eicosenoic acid + reduced acceptor + O2
20:2DELTA11,14 + acceptor + H2O
62% conversion
-
-
?
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O