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Information on EC 1.14.19.6 - acyl-CoA (9+3)-desaturase

for references in articles please use BRENDA:EC1.14.19.6

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IUBMB Comments

This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. When acting on 19:1Δ10 fatty acyl-CoA the enzyme from the pathogenic protozoan Trypanosoma brucei introduces the new double bond at position 13, indicating that the new double bond is introduced three carbons from the existing cis double bond, towards the methyl-end of the fatty acid. Requires cytochrome b5 as the electron donor .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
delta 12 desaturase, fad-2, delta-12 fatty acid desaturase, le-fad2, delta 12 fatty acid desaturases, ptfad2, klfad2, delta12-fad, egfad2, csfad2a, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
oleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = linoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(1)
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palmitoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (9Z,12Z)-hexadeca-9,12-dienoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
linoleate biosynthesis II (animals), sorgoleone biosynthesis