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Information on EC 1.14.14.14 - aromatase and Organism(s) Mus musculus and UniProt Accession P28649

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IUBMB Comments
A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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This record set is specific for:
Mus musculus
UNIPROT: P28649
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
aromatase, cyp19a1, cyp19a1a, cyp19a, cyp19a1b, cyp19a3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CYP19A1
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
testosterone monooxygenase (17beta-estradiol-forming)
A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
higher aromatase expression in female compared with male cerebral vessels
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
in a male mouse model overexpressing the aromatase enzyme, adipose tissue estradiol levels are increased while circulating sex steroid levels are unaffected. The overexpressing male mice are more insulin sensitive compared with wild-type mice and exhibit increased serum adiponectin levels and upregulated expression of Glut4 and Irs1 in white adipose tissue. The expression of markers of macrophages and immune cell infiltration is markedly decreased in their white adipose tissue
physiological function
cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CP19A_MOUSE
503
0
58015
Swiss-Prot
Secretory Pathway (Reliability: 4)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ohlsson, C.; Hammarstedt, A.; Vandenput, L.; Saarinen, N.; Ryberg, H.; Windahl, S.H.; Farman, H.H.; Jansson, J.O.; Moverare-Skrtic, S.; Smith, U.; Zhang, F.P.; Poutanen, M.; Hedjazifar, S.; Sjoegren, K.
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice
Am. J. Physiol. Endocrinol. Metab.
313
E450-E462
2017
Mus musculus (P28649), Mus musculus
Manually annotated by BRENDA team
Zuloaga, K.L.; Davis, C.M.; Zhang, W.; Alkayed, N.J.
Role of aromatase in sex-specific cerebrovascular endothelial function in mice
Am. J. Physiol. Heart Circ. Physiol.
306
H929-H937
2014
Mus musculus (P28649)
Manually annotated by BRENDA team
Sun, C.; Liu, Y.; Liu, Y.; Zhao, M.; Zhai, J.; Hao, P.; Wang, Y.; Ji, Y.
Characterization of aromatase expression in the spinal cord of an animal model of familial ALS
Brain Res. Bull.
132
180-189
2017
Mus musculus (P28649), Mus musculus
Manually annotated by BRENDA team