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Information on EC 1.14.13.9 - kynurenine 3-monooxygenase and Organism(s) Cytophaga hutchinsonii and UniProt Accession Q11PP7

for references in articles please use BRENDA:EC1.14.13.9
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IUBMB Comments
A flavoprotein (FAD).
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This record set is specific for:
Cytophaga hutchinsonii
UNIPROT: Q11PP7
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Word Map
The taxonomic range for the selected organisms is: Cytophaga hutchinsonii
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
cinnabar, kmo, kynurenine 3-monooxygenase, kynurenine 3-hydroxylase, kynurenine hydroxylase, kynurenine monooxygenase, kynurenine-3-monooxygenase, pfkmo, nadph-dependent flavin monooxygenase, kyn-ohase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
kynurenine 3-hydroxylase
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-
-
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kynurenine hydroxylase
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-
-
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L-kynurenine-3-hydroxylase
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-
-
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oxygenase, kynurenine 3-mono-
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
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oxidation
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-
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reduction
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
A flavoprotein (FAD).
CAS REGISTRY NUMBER
COMMENTARY hide
9029-61-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-bromo-L-kynurenine + NADPH + H+ + O2
5-bromo-3-hydroxy-L-kynurenine + NADP+ + H2O
show the reaction diagram
-
-
-
?
5-chloro-L-kynurenine + NADPH + H+ + O2
5-chloro-3-hydroxy-L-kynurenine + NADP+ + H2O
show the reaction diagram
-
-
-
?
L-kynurenine + NADPH + H+ + O2
3-hydroxy-L-kynurenine + NADP+ + H2O
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-kynurenine + NADPH + H+ + O2
3-hydroxy-L-kynurenine + NADP+ + H2O
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,4-dichlorohippuric acid
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3,4-dimethoxyhippuric acid
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3,5-dibromo-L-kynurenine
potent competitive inhibitor
3-chloro-DL-kynurenine
-
3-methyl-DL-kynurenine
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5-bromo-3-chloro-DL-kynurenine
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5-bromo-3-methyl-DL-kynurenine
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0045
5-bromo-L-kynurenine
pH and temperature not specified in the publication
0.002
5-chloro-L-kynurenine
pH and temperature not specified in the publication
0.067
L-kynurenine
pH and temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.6
5-bromo-L-kynurenine
pH and temperature not specified in the publication
0.8
5-chloro-L-kynurenine
pH and temperature not specified in the publication
2
L-kynurenine
pH and temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
133.3
5-bromo-L-kynurenine
pH and temperature not specified in the publication
400
5-chloro-L-kynurenine
pH and temperature not specified in the publication
29.9
L-kynurenine
pH and temperature not specified in the publication
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.034
3,4-dichlorohippuric acid
pH and temperature not specified in the publication
1
3,4-dimethoxyhippuric acid
pH and temperature not specified in the publication
0.0015
3,5-dibromo-L-kynurenine
pH and temperature not specified in the publication
0.0138
3-chloro-DL-kynurenine
pH and temperature not specified in the publication
0.0086
3-methyl-DL-kynurenine
pH and temperature not specified in the publication
0.011
5-bromo-3-chloro-DL-kynurenine
pH and temperature not specified in the publication
0.0102
5-bromo-3-methyl-DL-kynurenine
pH and temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug target
the enzyme is a potential drug target for treatment of neurodegenerative disorders such as Huntington's and Alzheimer's diseases
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
the enzyme is a potential drug target for treatment of neurodegenerative disorders such as Huntington's and Alzheimer's diseases
pharmacology
the enzyme is a potential drug target for treatment of neurodegenerative disorders such as Huntington's and Alzheimer's diseases
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Phillips, R.S.; Anderson, A.D.; Gentry, H.G.; Guener, O.F.; Bowen, J.P.
Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii
Bioorg. Med. Chem. Lett.
27
1705-1708
2017
Cytophaga hutchinsonii (Q11PP7), Cytophaga hutchinsonii
Manually annotated by BRENDA team