EC Number   |
General Information |
Reference |
|---|
    1.14.13.9 | drug target |
contents of L-tryptophan and monoamines and their metabolites are measured in the serum and hippocampus of kynurenine 3-monooxygenase KO mice. It is investigated whether antidepressants improve the depressive-like behaviors in kynurenine 3-monooxygenase KO mice. KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as model for major depressive disorder |
741802 |
| 1.14.13.9 | drug target |
inhibition of the enzyme shows benefit in neurodegenerative diseases such as Huntingtons and Alzheimers. It is a target for acute pancreatitis multiple organ dysfunction syndrome |
743342 |
| 1.14.13.9 | drug target |
kynurenine represents a branch point of the kynurenine pathway, being converted into the neurotoxin 3-hydroxykynurenine via kynurenine monooxygenase, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, kynurenine monooxygenase is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's, Alzheimer's, and Parkinson's diseases |
742349 |
| 1.14.13.9 | drug target |
the enzyme is a clinical candidate for the treatment of acute pancreatitis |
743067 |
| 1.14.13.9 | drug target |
the enzyme is a potential drug target for treatment of neurodegenerative disorders such as Huntington's and Alzheimer's diseases |
742081 |
| 1.14.13.9 | drug target |
the enzyme is a potential therapeutic target for neurodegenerative and neurologic disorders |
742478 |
| 1.14.13.9 | drug target |
the enzyme is a therapeutic target in several disease states, including Huntington's disease |
743747 |
| 1.14.13.9 | evolution |
KMO belongs to a family of NAD(P)H-dependent flavin monooxygenase (FMO). KMO has one dicucleotide binding domain, which simply categorizes it as a Class A flavoprotein aromatic hydroxylase |
765436 |
| 1.14.13.9 | evolution |
KMO is a class A external flavoprotein aromatic hydroxylase (FAH). This class of enzymes uses the isoalloxazine ring of FAD to mediate the delivery of electrons from singlet state NADPH to the molecular oxygen ground state triplet in order to promote subsequent hydroxylation of singlet state molecules |
764027 |
| 1.14.13.9 | malfunction |
adaptiveand possibly regulatory-changes in mice with a targeted deletion of kynurenine 3-monooxygenase (Kmo-/-) are investigated kynurenine 3-monooxygenase-deficient mice are characterized using six behavioral assays relevant for the study of schizophrenia. Elimination of kynurenine 3-monooxygenase in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorder |
742039 |
