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BRENDA support

Ligand L-kynurenine

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Basic Ligand Information

Molecular Structure
Picture of L-kynurenine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H12N2O3
L-kynurenine
YGPSJZOEDVAXAB-QMMMGPOBSA-N
Synonyms:
3-(2-aminobenzoyl)-L-alanine, kynurenine, N-alpha-L-kynurenine


Show all pahtways known for Show all BRENDA pathways known for L-kynurenine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (34 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (245 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
kynurenine = ?
show the reaction diagram
-
kynurenine + FADH2 + chloride + O2 + H+ = 5-chloro-kynurenine + FAD + 2 H2O
show the reaction diagram
-
kynurenine + 2-oxoglutarate = kynurenic acid + L-glutamate
show the reaction diagram
kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
show the reaction diagram
-
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
show the reaction diagram
-
L-kynurenine + glyoxylate = 3-(2-aminophenyl-)2,4-dioxobutanoate + glycine
show the reaction diagram
-
L-kynurenine + 2-oxoglutarate = L-glutamate + 4-(2-aminophenyl)-2,4-dioxobutanoate
show the reaction diagram
-
kynurenine = ?
show the reaction diagram

Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tryptophan + O2 = L-kynurenine
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces
-
stimulates conversion of prostaglandin G1 to H1
-

Inhibitor in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 17.7% inhibition. 1 mM, 93.6% inhibition
-
24% inhibition at 0.1 mM
-
cysteine conjugate beta-lyase activity

3D Structure of Enzyme-Ligand-Complex (PDB) (36 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (34 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0085
-
wild-type enzyme, pH and temperature not specified in the publication
0.0085
-
wild-type enzyme, pH and temperature not specified in the publication
198
-
at pH 7.4 and 37°C
12
-
in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C
4.1
-
pH 7.4, 25°C, recombinant enzyme, with cosubstrate 2-oxoglutarate
1100
-
pH 8.0, 25°C

KM Value (81 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.241
-
wild-type enzyme, pH and temperature not specified in the publication
0.241
-
wild-type enzyme, pH and temperature not specified in the publication
3.7
-
in 100 mM potassium phosphate buffer (pH 7.5) for 5 min at 45°C
9
-
pH 7.4, 25°C, recombinant enzyme, with cosubstrate 2-oxoglutarate
3.2
-
pH 8.0, 25°C
0.4
-
-

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.01152
-
pH and temperature not specified in the publication
0.01152
-
inhibition of TAA1, competitive versus L-Tryp, pH not specificied in the publication, 55°C
0.25
-
-

References & Links

Links to other databases for L-kynurenine

ChEBI
PubChem
ChEBI
PubChem