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Information on EC 1.14.13.101 - senecionine N-oxygenase

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IUBMB Comments
A flavoprotein. NADH cannot replace NADPH. While pyrrolizidine alkaloids of the senecionine and monocrotaline types are generally good substrates (e.g. senecionine, retrorsine and monocrotaline), the enzyme does not use ester alkaloids lacking an hydroxy group at C-7 (e.g. supinine and phalaenopsine), 1,2-dihydro-alkaloids (e.g. sarracine) or unesterified necine bases (e.g. senkirkine) as substrates . Senecionine N-oxide is used by insects as a chemical defense: senecionine N-oxide is non-toxic, but it is bioactivated to a toxic form by the action of cytochrome P-450 oxidase when absorbed by insectivores.
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The enzyme appears in viruses and cellular organisms
Synonyms
GgPNO, oxygenase, senecionine N-, PA N-oxygenase, PNO, senecionine monooxygenase (N-oxide-forming), senecionine N-oxygenase, SNO, TjSNO, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O
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