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Information on EC 1.1.98.2 - glucose-6-phosphate dehydrogenase (coenzyme-F420)
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EC Tree
1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420)IUBMB Comments
The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, FAD and FMN .
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Word Map
- 1.1.98.2
- mycobacteria
- tuberculosis
- smegmatis
- archaea
- bovis
- 6-phosphogluconolactone
-
hydride
-
pretomanid
- leprae
-
prodrug
- citrate
-
nadp-dependent
-
methanogenic
- 5-deazaflavin
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
Synonyms
f420-dependent glucose-6-phosphate dehydrogenase, rv0407, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Rv0407
-
-
-
-
EC 1.1.99.34
-
-
formerly
-
F420-dependent glucose-6-phosphate dehydrogenase
FGD
FGD1
F420-dependent glucose-6-phosphate dehydrogenase
-
-
F420-dependent glucose-6-phosphate dehydrogenase
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + oxidized coenzyme F420 = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:F420 1-oxidoreductase
The enzyme is very specific for D-glucose 6-phosphate. No activity with NAD+, NADP+, FAD and FMN [1].
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CAS REGISTRY NUMBER
COMMENTARY
176898-36-5
-
9001-40-5
cf. EC 1.1.1.49
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate + oxidized coenzyme F420
? + reduced coenzyme F420
-
4.8% activity compared to D-glucose 6-phosphate
-
-
?
D-fructose-6-phosphate + oxidized coenzyme F420
?
-
9% of the activity with 2 mM D-glucose 6-phosphate
-
-
?
D-glucosamine 6-phosphate + oxidized coenzyme F420
?
-
2.8% activity compared to D-glucose 6-phosphate
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
D-mannose 6-phosphate + oxidized coenzyme F420
6-phospho-D-mannono-1,5-lactone + reduced coenzyme F420
-
1.1% activity compared to D-glucose 6-phosphate
-
-
?
D-mannose-6-phosphate + oxidized coenzyme F420
?
-
5% of the activity with 2 mM D-glucose 6-phosphate
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
100% activity
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Gordona amarae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium avium: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium gordonae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium kansasii: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?, ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium scrofulaceum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium fortuitum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are to separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
the purified enzyme used F420 as its obligate electron acceptor when D-glucose 6-phosphate is the substrate. NAD, NADP, flavin adenine dinucleotide, and flavin mononucleotide show no reactivity. The enzyme is very specific for D-glucose 6-phosphate. At pH 7.0 and 22°C, 10 mM D-mannose-6-phosphate and D-fructose-6-phosphate show 5% and 9%, respectively, of the activity with 2 mM D-glucose 6-phosphate. No activity with: D-fructose-1-phosphate, D-galactose-1-phosphate, D-galactose-6-phosphate, L-fucose-1-phosphate, D-glucose-1-phosphate, D-ribose-5-phosphate, D-ribose-1-phosphate, D-arabinose-5-phosphate, glyceraldehyde-3-phosphate, and glycerol-3-phosphate
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?, ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia brasiliensis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia otitidiscaviarum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia tartaricans: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
additional information
?
-
-
intracellular glucose-6-phosphate in mycobacteria serves as a source of reducing power, and with the mycobacteria-specific F420-dependent glucose-6-phosphate dehydrogenase/F420 system, plays a protective role against oxidative stress imposed by host macrophages
-
-
?
additional information
?
-
-
there is no detectable enzyme activity with alpha-Dglucose 1-phosphate and alpha-D-galactose 1-phosphate. The enzyme also accepts D-glucose as substrate, although with very low catalytic activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
additional information
?
-
-
intracellular glucose-6-phosphate in mycobacteria serves as a source of reducing power, and with the mycobacteria-specific F420-dependent glucose-6-phosphate dehydrogenase/F420 system, plays a protective role against oxidative stress imposed by host macrophages
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Gordona amarae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium avium: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium gordonae: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium kansasii: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?, ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium scrofulaceum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
Mycobacterium tuberculosis H37Ra / ATCC 25177
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Ra: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium tuberculosis Rv: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium fortuitum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are to separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Mycobacterium smegmatis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?, ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia brasiliensis: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia otitidiscaviarum: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
-
-
-
?
D-glucose 6-phosphate + oxidized coenzyme F420
D-glucono-1,5-lactone 6-phosphate + reduced coenzyme F420
-
there are two separate glucose-6-phosphate dehydrogenase activities in Nocardia tartaricans: coenzyme F420-dependent glucose-6-phosphate dehydrogenase and NADP+-dependent glucose-6-phosphate dehydrogenase (EC 1.1.1.49)
-
-
ir
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
the enzyme shows no significant activity when NAD+, NADP+, FAD, or FMN is used as alternative electron acceptor
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
no inhibition: D-fructose-1-phosphate, D-galactose-1-phosphate, D-galactose-6-phosphate, L-fucose-1-phosphate, D-glucose-1-phosphate, D-ribose-5-phosphate, D-ribose-1-phosphate, D-arabinose-5-phosphate, glyceraldehyde-3-phosphate, and glycerol-3-phosphate
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Tuberculosis
Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.022
D-glucose 6-phosphate
wild type enzyme, at pH 7.0 and 22°C
0.027
D-glucose 6-phosphate
mutant enzyme H40A, at pH 7.0 and 22°C
0.041
D-glucose 6-phosphate
mutant enzyme E109Q, at pH 7.0 and 22°C
0.17
D-glucose 6-phosphate
mutant enzyme W44Y, at pH 7.0 and 22°C
0.28
D-glucose 6-phosphate
mutant enzyme W44A, at pH 7.0 and 22°C
0.34
D-glucose 6-phosphate
mutant enzyme W44F, at pH 7.0 and 22°C
100
D-glucose 6-phosphate
-
Km above 100 mM, mutant enzyme R282Q, at pH 7.5 and 25°C
0.0009
oxidized coenzyme F420
mutant enzyme W44A, at pH 7.0 and 22°C
0.0026
oxidized coenzyme F420
wild type enzyme, at pH 7.0 and 22°C
0.0042
oxidized coenzyme F420
mutant enzyme W44Y, at pH 7.0 and 22°C
0.0054
oxidized coenzyme F420
mutant enzyme W44F, at pH 7.0 and 22°C
0.0056
oxidized coenzyme F420
mutant enzyme E109Q, at pH 7.0 and 22°C
0.008
oxidized coenzyme F420
mutant enzyme H40A, at pH 7.0 and 22°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0012
D-glucose 6-phosphate
mutant enzyme W44A, at pH 7.0 and 22°C
0.0016
D-glucose 6-phosphate
mutant enzyme H40A, at pH 7.0 and 22°C
0.023
D-glucose 6-phosphate
mutant enzyme E109Q, at pH 7.0 and 22°C
0.041
D-glucose 6-phosphate
mutant enzyme W44Y, at pH 7.0 and 22°C
0.047
D-glucose 6-phosphate
-
kcat above 0.047 s-1, mutant enzyme R282Q, at pH 7.5 and 25°C
1.4
D-glucose 6-phosphate
wild type enzyme, at pH 7.0 and 22°C
3.5
D-glucose 6-phosphate
mutant enzyme W44F, at pH 7.0 and 22°C
0.001
oxidized coenzyme F420
mutant enzyme W44A, at pH 7.0 and 22°C
0.002
oxidized coenzyme F420
mutant enzyme H40A, at pH 7.0 and 22°C
0.02
oxidized coenzyme F420
mutant enzyme E109Q, at pH 7.0 and 22°C
0.06
oxidized coenzyme F420
mutant enzyme W44Y, at pH 7.0 and 22°C
1.4
oxidized coenzyme F420
wild type enzyme, at pH 7.0 and 22°C
3.2
oxidized coenzyme F420
mutant enzyme W44F, at pH 7.0 and 22°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.004
D-glucose 6-phosphate
mutant enzyme W44A, at pH 7.0 and 22°C
0.06
D-glucose 6-phosphate
mutant enzyme H40A, at pH 7.0 and 22°C
0.1
D-glucose 6-phosphate
mutant enzyme E109Q, at pH 7.0 and 22°C
0.2
D-glucose 6-phosphate
mutant enzyme W44Y, at pH 7.0 and 22°C
10
D-glucose 6-phosphate
mutant enzyme W44F, at pH 7.0 and 22°C
60
D-glucose 6-phosphate
wild type enzyme, at pH 7.0 and 22°C
0.4
oxidized coenzyme F420
mutant enzyme H40A, at pH 7.0 and 22°C
1
oxidized coenzyme F420
mutant enzyme W44A, at pH 7.0 and 22°C
4
oxidized coenzyme F420
mutant enzyme E109Q, at pH 7.0 and 22°C
20
oxidized coenzyme F420
mutant enzyme W44Y, at pH 7.0 and 22°C
600
oxidized coenzyme F420
wild type enzyme, at pH 7.0 and 22°C
600
oxidized coenzyme F420
mutant enzyme W44F, at pH 7.0 and 22°C
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 8.5
-
pH 5: about 60% of maximal activity, pH 5.5: maximum, pH 7: about 50% of maximal activity, pH 8.0: maximal activity, pH 8.5: about 60% of maximal activity