Reference on EC 1.1.1.50 - 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Biswas, M.G.; Russel, D.W.
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenase from rat and human prostate
J. Biol. Chem.
272
15959-15966
1997
Homo sapiens, Rattus norvegicus
Chetyrkin, S.V.; Belyaeva, O.V.; Gough, W.H.; Kedishvili, N.Y.
Characterization of a novel type of human microsomal 3alpha-hydroxysteroid dehydrogenase
J. Biol. Chem.
276
22278-22286
2001
Homo sapiens
Iyer, R.B.; Binstock, J.M.; Schwartz, I.S.; Gordon, G.G.; Weinstein, B.I.; Southern, A.L.
Purification and properties of human hepatic 3alpha-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
43
343-349
1992
Homo sapiens
Lin, H.K.; Jez, J.M.; Schlegel, B.P.; Peehl, D.M.; Pachter, J.A.; Penning, T.M.
Expression and characterization of recombinant type 2: 3alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3alpha/17beta-HSD activity and cellular distribution
Mol. Endocrinol.
11
1971-1984
1997
Homo sapiens
Jin, Y.; Stayrook, S.E.; Albert, J.H.; Palackal, N.T.; Penning, T.M.; Lewis, M.
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
Biochemistry
40
10161-10168
2001
Homo sapiens
Zhu, D.W.; Cantin, L.; Nahoum, V.; Rehse, P.; Luu-The, V.; Labrie, F.; Breton, R.; Lin S.X.
Crystallization and preliminary X-ray crystallographic analysis of the human type 3 3alpha-hydroxysteroid dehydrogenase at 1.8 A resolution
Acta Crystallogr. Sect. D
57
589-591
2001
Homo sapiens
Trauger, J.W.; Jiang, A.; Stearns, B.A.; LoGrasso, P.V.
Kinetics of allopregnanolone formation catalyzed by human 3alpha-hydroxysteroid dehydrogenase type III (AKR1C2)
Biochemistry
41
13451-13459
2002
Homo sapiens
Usami, N.; Yamamoto, T.; Shintani, S.; Ishikura, S.; Higaki, Y.; Katagiri, Y.; Hara, A.
Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines
Biol. Pharm. Bull.
25
441-445
2002
Homo sapiens
Jin, Y.; Cooper, W.C.; Penning, T.M.
Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase
Chem. Biol. Interact.
143-144
383-392
2003
Homo sapiens, Rattus norvegicus
Rizner, T.L.; Lin, H.K.; Peehl, D.M.; Steckelbroeck, S.; Bauman, D.R.; Penning, T.M.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
Endocrinology
144
2922-2932
2003
Homo sapiens
Yee, D.J.; Balsanek, V.; Sames, D.
New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3a-hydroxysteroid dehydrogenases
J. Am. Chem. Soc.
126
2282-2283
2004
Comamonas testosteroni, Homo sapiens, Rattus norvegicus
Steckelbroeck, S.; Jin, Y.; Gopishetty, S.; Oyesanmi, B.; Penning, T.M.
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action
J. Biol. Chem.
279
10784-10795
2004
Homo sapiens (Q04828), Homo sapiens
Penning, T.M.; Jin, Y.; Heredia, V.V.; Lewis, M.
Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms
J. Steroid Biochem. Mol. Biol.
85
247-255
2003
Homo sapiens, Rattus norvegicus
Penning, T.M.; Jin, Y.; Steckelbroeck, S.; Lanisnik Rizner, T.; Lewis, M.
Structure-function of human 3alpha-hydroxysteroid dehydrogenases: genes and proteins
Mol. Cell. Endocrinol.
215
63-72
2004
Homo sapiens
Steckelbroeck, S.; Jin, Y.; Oyesanmi, B.; Kloosterboer, H.J.; Penning, T.M.
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: Inversion of stereospecificity with a DELTA5(10)-3-ketosteroid
Mol. Pharmacol.
66
1702-1711
2004
Homo sapiens (Q04828), Homo sapiens
Jin, Y.; Penning, T.M.
Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens
Biochemistry
45
13054-13063
2006
Homo sapiens
Steckelbroeck, S.; Oyesanmi, B.; Jin, Y.; Lee, S.H.; Kloosterboer, H.J.; Penning, T.M.
Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
J. Pharmacol. Exp. Ther.
316
1300-1309
2006
Homo sapiens
Yee, D.J.; Balsanek, V.; Bauman, D.R.; Penning, T.M.; Sames, D.
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells
Proc. Natl. Acad. Sci. USA
103
13304-13309
2006
Homo sapiens
Azzarello, J.; Fung, K.M.; Lin, H.K.
Tissue distribution of human AKR1C3 and rat homolog in adult genitourinary system
J. Histochem. Cytochem.
56
853-861
2008
Homo sapiens, Rattus norvegicus
Wang, S.; Yang, Q.; Fung, K.M.; Lin, H.K.
AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells
Mol. Cell. Endocrinol.
289
60-66
2008
Homo sapiens
Stayrook, K.R.; Rogers, P.M.; Savkur, R.S.; Wang, Y.; Su, C.; Varga, G.; Bu, X.; Wei, T.; Nagpal, S.; Liu, X.S.; Burris, T.P.
Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha
Mol. Pharmacol.
73
607-612
2008
Homo sapiens
Hidai, C.; Kitano, H.; Kokubun, S.
The Del1 deposition domain can immobilize 3alpha-hydroxysteroid dehydrogenase in the extracellular matrix without interfering with enzymatic activity
Bioprocess Biosyst. Eng.
32
569-573
2009
Homo sapiens, Mus musculus (Q91WR5)
Zhang, B.; Zhu, D.; Hu, X.; Zhou, M.; Shang, P.; Lin, S.
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity
J. Steroid Biochem. Mol. Biol.
141
135-143
2014
Homo sapiens (Q04828)
Zhang, B.; Hu, X.; Wang, X.; Theriault, J.; Zhu, D.; Shang, P.; Labrie, F.; Lin, S.
Human 3alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth
Biochem. J.
473
1037-1046
2016
Homo sapiens (P52895)
