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Information on EC 1.1.1.343 - phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) and Organism(s) Bacillus subtilis and UniProt Accession P12013

for references in articles please use BRENDA:EC1.1.1.343
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IUBMB Comments
Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway . cf. EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating).
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Bacillus subtilis
UNIPROT: P12013
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The taxonomic range for the selected organisms is: Bacillus subtilis
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
6-phospho-gluconate dehydrogenase, 6-phospho-d-gluconate:nad+ 2-oxidoreductase (decarboxylating), nad-specific 6-phosphogluconate dehydrogenase, nad+-dependent 6-p-gluconate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NAD+-dependent 6-P gluconate dehydrogenase
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NAD+-dependent 6-P-gluconate dehydrogenase
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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating)
Highly specific for NAD+. The enzyme catalyses both the oxidation and decarboxylation of 6-phospho-D-gluconate. In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway [4]. cf. EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating).
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
show the reaction diagram
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6-phospho-D-gluconate + NAD+
D-ribulose 5-phosphate + CO2 + NADH + H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
gntZ mutants exhibit no detectable phenotype on glucose
physiological function
GntZ does not contribute to pentose phosphate pathway fluxes during growth on glucose
malfunction
gntZ mutants grow normally on glucose
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zamboni, N.; Fischer, E.; Laudert, D.; Aymerich, S.; Hohmann, H.P.; Sauer, U.
The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway
J. Bacteriol.
186
4528-4534
2004
Bacillus subtilis, Bacillus subtilis (P12013), Bacillus subtilis 168, Bacillus subtilis 168 (P12013)
Manually annotated by BRENDA team