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Information on EC 1.1.1.28 - D-lactate dehydrogenase and Organism(s) Leuconostoc mesenteroides and UniProt Accession P51011

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Leuconostoc mesenteroides
UNIPROT: P51011 not found.
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Word Map
The taxonomic range for the selected organisms is: Leuconostoc mesenteroides
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
ldh, d-lactate dehydrogenase, d-ldh, paldh, fermentative lactate dehydrogenase, nad-dependent d-lactate dehydrogenase, d-nldh, ljd-ldh, d-(-)-lactate dehydrogenase, d-ldh82319, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-(-)-lactate dehydrogenase (NAD)
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D-lactic acid dehydrogenase
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D-lactic dehydrogenase
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D-LDH
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D-specific lactic dehydrogenase
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dehydrogenase, D-lactate
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Fermentative lactate dehydrogenase
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lactic acid dehydrogenase
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LDH
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Respiratory D-lactate dehydrogenase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(R)-lactate:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
9028-36-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-lactate + NAD+
pyruvate + NADH
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-lactate + NAD+
pyruvate + NADH
show the reaction diagram
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-
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iodoacetamide
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
subsp. mesenteroides strain NBRC3426
Uniprot
Manually annotated by BRENDA team
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35
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stable below, Tris-HCl, pH 8.5
40
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stable below, phosphate buffer, pH 7.5
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
construction of a metabolically engineered Saccharomyces cerevisiae that produces D-lactic acid efficiently. Two copies of the D-lactate dehydrogenase gene from Leuconostoc mesenteroides subsp. mesenteroides strain NBRC3426 are introduced into the genome
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
construction of a metabolically engineered Saccharomyces cerevisiae that produces D-lactic acid efficiently. Two copies of the D-lactate dehydrogenase gene from Leuconostoc mesenteroides subsp. mesenteroides strain NBRC3426 are introduced into the genome. The D-lactate production reaches 61.5 g/l, the amount of glucose being transformed into D-lactic acid is 53.0% under non-neutralizing conditions. The D-lactic acid is of extremely high optical purity of 99.9% or higher
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garvie, E.I.
Bacterial lactate dehydrogenases
Microbiol. Rev.
44
106-139
1980
Klebsiella aerogenes, Leuconostoc mesenteroides, Eubacterium limosum, Escherichia coli, Lactobacillus acidophilus, Lactiplantibacillus plantarum, Levilactobacillus brevis, Lentilactobacillus buchneri, Lactobacillus delbrueckii subsp. bulgaricus, Lacticaseibacillus casei, Limosilactobacillus fermentum, Weissella confusa, Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. lactis, Lactobacillus jensenii, Lactobacillus jugurt-helveticus, Lactobacillus leichmannii, Lactobacillus vermiforme, Weissella viridescens, Lactococcus lactis, Leuconostoc mesenteroides subsp. cremoris, Leuconostoc mesenteroides subsp. dextranicum, Leuconostoc lactis, Oenococcus oeni, Weissella paramesenteroides, Mammalia, Staphylococcus aureus, Mycoplasma sp., Pediococcus acidilactici, Pediococcus damnosus, Pediococcus inopinatus, Pediococcus pentosaceus, Selenomonas ruminantium, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus sp., Staphylococcus warneri
Manually annotated by BRENDA team
Ishida, N.; Suzuki, T.; Tokuhiro, K.; Nagamori, E.; Onishi, T.; Saitoh, S.; Kitamoto, K.; Takahashi, H.
D-lactic acid production by metabolically engineered Saccharomyces cerevisiae
J. Biosci. Bioeng.
101
172-177
2006
Leuconostoc mesenteroides (P51011)
Manually annotated by BRENDA team