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Information on EC 1.1.1.170 - 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
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1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)IUBMB Comments
The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol. It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules. The first enzyme, EC 1.14.18.9, 4alpha-methylsterol monooxygenase, catalyses three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyses an oxidative decarboxylation that results in a reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, reduces the 3-oxo group back to a 3beta-hydroxyl. If a second methyl group remains at the C-4 position, this enzyme also catalyses its epimerization from 4beta to 4alpha orientation, so it could serve as a substrate for a second round of demethylation. cf. EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating).
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
nsdhl, erg26, erg26p, sterol-4-alpha-carboxylate 3-dehydrogenase, sterol-4-alpha-carboxylate-3-dehydrogenase, sterol-4alpha-carboxylate 3-dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
-
-
-
-
3beta-hydroxy-4beta-methylcholestenoate dehydrogenase
-
-
-
-
C-3 sterol dehydrogenase(C-4 decarboxylase)
Erg26
Erg26p
NSDHL
sterol 4alpha-carboxylic decarboxylase
-
-
-
-
sterol-4-alpha-carboxylate-3-dehydrogenase
sterol-4alpha-carboxylate 3-dehydrogenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)+ = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NAD(P)H + H+
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
The enzyme participates in the biosynthesis of several important sterols such as ergosterol and cholesterol. It is part of a three enzyme system that removes methyl groups from the C-4 position of steroid molecules. The first enzyme, EC 1.14.18.9, 4alpha-methylsterol monooxygenase, catalyses three successive oxidations of the methyl group, resulting in a carboxyl group; the second enzyme, EC 1.1.1.170, catalyses an oxidative decarboxylation that results in a reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group; and the last enzyme, EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, reduces the 3-oxo group back to a 3beta-hydroxyl. If a second methyl group remains at the C-4 position, this enzyme also catalyses its epimerization from 4beta to 4alpha orientation, so it could serve as a substrate for a second round of demethylation. cf. EC 1.1.1.418, plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating).
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CAS REGISTRY NUMBER
COMMENTARY
71822-23-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylate + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
-
-
-
?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-en-4alpha-oic acid + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
-
no epimerization of 4beta-isomer into 4alpha-isomer
-
ir
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate + NAD+
4alpha-methyl-cholest-8,24-dien-3-one + CO2 + NADH
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
3-dehydro-4-methylzymosterol + NADPH + CO2
-
-
-
-
?
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
-
-
?
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
5alpha-cholesta-8,24-dien-3-one + NADPH + CO2
-
-
-
-
?
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
-
-
?
additional information
?
-
-
involved in the removal of C-4 methyl groups in postsqualene cholesterol synthesis
-
-
?
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate + NAD+
4alpha-methyl-cholest-8,24-dien-3-one + CO2 + NADH
-
-
-
?
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate + NAD+
4alpha-methyl-cholest-8,24-dien-3-one + CO2 + NADH
-
-
-
?
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate + NAD+
4alpha-methyl-cholest-8,24-dien-3-one + CO2 + NADH
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylate + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
-
-
-
?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-en-4alpha-oic acid + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
-
no epimerization of 4beta-isomer into 4alpha-isomer
-
ir
additional information
?
-
-
involved in the removal of C-4 methyl groups in postsqualene cholesterol synthesis
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
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-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
FR171456
a natural specific inhibitor of yeast Erg26p from Monodictys sp.. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in yeast cells. FR171456 causes significant growth inhibition of strain SC5314 at. Erg26p inhibition requires the 4alpha-carboxyl group of FR171456, substitution of the 4alpha-carboxylic group of FR171456 by a carbobenzylamido group (Compound-1) decreases inhibition
FR171456
a natural specific inhibitor of mammalian NSDHL from Monodictys sp.. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in human cells. R171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. In a screen to profile compound activity against 503 cancer cell lines only five cell lines are sensitive to FR171456 with IC50 values below 0.005 mM. Calcidiol, a cholesterol metabolite situated downstream of NSDHL, is decreased in a FR171456 dose-dependent manner, consistent with a reduction of cholesterol synthesis, and new derivatives of NSDHL substrates are deteremined in the cells that are no longer effective as substrates
FR171456
a natural specific inhibitor of yeast Erg26p from Monodictys sp.. Genomic profiling identifies Erg26p as the FR171456 target, the ERG26 heterozygous strain (erg26DELTA/ERG26) shows the most significant hypersensitivity to FR171456. FR171456 is a natural product with cholesterol-lowering properties in animal models. FR171456 significantly alters the levels of cholesterol pathway intermediates in yeast cells. FR171456 causes significant growth inhibition of strain BY4743 at concentrations up to 0.2 mM. Multiple mutations, e.g. Gly90Ser, in enzyme ERG26 confer resistance to FR171456 in growth and enzyme assays. FR171456 inhibits an artificial Hepatitis C viral replicon, and has broad antifungal activity, suggesting potential additional utility as an anti-infective. Erg26p inhibition requires the 4a-carboxyl group of FR171456, substitution of the 4alpha-carboxylic group of FR171456 by a carbobenzylamido group (Compound-1) decreases inhibition by 300fold. FR171456 docking into a homology model of Erg26p. Modelling FR171456 resistance mutations on Erg26p, overview
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) deficiency
Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development.
Brain Diseases
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Breast Neoplasms
NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis.
Breast Neoplasms
NSDHL promotes triple-negative breast cancer metastasis through the TGF? signaling pathway and cholesterol biosynthesis.
Carcinoma
A New Survival Model Based on Cholesterol Biosynthesis-Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma.
Carcinoma
Cholesterol Pathway Inhibition Induces TGF-? Signaling to Promote Basal Differentiation in Pancreatic Cancer.
Carcinoma
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR.
Dermatitis, Exfoliative
Novel NSDHL gene variant for congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome.
Hypoventilation
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Intellectual Disability
Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.
Intellectual Disability
Hypomorphic temperature-sensitive alleles of NSDHL cause CK syndrome.
Muscular Diseases
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Neoplasm Metastasis
NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis.
Neoplasm Metastasis
NSDHL promotes triple-negative breast cancer metastasis through the TGF? signaling pathway and cholesterol biosynthesis.
Neoplasms
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Neoplasms
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR.
Neoplasms
NAD(P)-dependent steroid dehydrogenase-like is involved in breast cancer cell growth and metastasis.
Neoplasms
NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics.
Neoplasms
NSDHL promotes triple-negative breast cancer metastasis through the TGF? signaling pathway and cholesterol biosynthesis.
Neoplasms
Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.
Nevus
A missense variant in the NSDHL gene in a Chihuahua with a congenital cornification disorder resembling inflammatory linear verrucous epidermal nevi.
Nevus
Genetic variant in the NSDHL gene in a cat with multiple congenital lesions resembling inflammatory linear verrucous epidermal nevi.
Nevus
Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.
Nevus
Mutations in the NSDHL gene, encoding a 3beta-hydroxysteroid dehydrogenase, cause CHILD syndrome.
Placental Insufficiency
Significant contributions of the extraembryonic membranes and maternal genotype to the placental pathology in heterozygous Nsdhl deficient female embryos.
Stomach Neoplasms
NAD(P)-dependent steroid dehydrogenase-like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics.
Triple Negative Breast Neoplasms
NSDHL promotes triple-negative breast cancer metastasis through the TGF? signaling pathway and cholesterol biosynthesis.
Xanthomatosis
Identification of NSDHL mutations associated with CHILD syndrome in oral verruciform xanthoma.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.55
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate
pH 7.5, 30°C
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.5
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
30
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
I/LnJ and KK/HlJ inbred strains and cross breeds between KK/HlJ and I/LnJ
UniProt
brenda
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
additional information
malfunction
-
mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects
malfunction
a I/LnJ-specific nonsynonymous polymorphism in X-linked Nsdhl, which codes for sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway, causes reduced HDL cholesterol levels in plasma
metabolism
the enzyme sterol-4-alpha-carboxylate 3-dehydrogenase is important in the cholesterol synthesis pathway
metabolism
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
metabolism
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
metabolism
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
metabolism
-
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
-
physiological function
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
physiological function
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
physiological function
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
physiological function
-
the sterol-4-alpha-carboxylate-3-dehydrogenase is an essential enzyme in the ergosterol/cholesterol biosynthesis pathway
-
additional information
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
additional information
-
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
additional information
HDL and non-HDL lipid contents in different mouse genotypes and correlation to gene Nsdhl, overview
additional information
-
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ERG26_CANAL
Candida albicans (strain SC5314 / ATCC MYA-2876)
350
0
39184
Swiss-Prot
other Location (Reliability: 4)
ERG26_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
340
0
38318
Swiss-Prot
other Location (Reliability: 5)
ERG26_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
349
0
38706
Swiss-Prot
Secretory Pathway (Reliability: 5)
NSDHL_BOVIN
356
1
39902
Swiss-Prot
other Location (Reliability: 1)
NSDHL_DICDI
328
0
36765
Swiss-Prot
other Location (Reliability: 2)
NSDHL_HUMAN
373
1
41900
Swiss-Prot
other Location (Reliability: 1)
HSDD3_ARATH
561
3
63033
Swiss-Prot
other Location (Reliability: 2)
NSDHL_MOUSE
362
1
40686
Swiss-Prot
other Location (Reliability: 1)
NSDHL_RAT
362
1
40412
Swiss-Prot
other Location (Reliability: 1)
F0SPA9_RUBBR
Rubinisphaera brasiliensis (strain ATCC 49424 / DSM 5305 / JCM 21570 / IAM 15109 / NBRC 103401 / IFAM 1448)
332
0
36359
TrEMBL
-
A2R589_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
412
0
45622
TrEMBL
Secretory Pathway (Reliability: 2)
E7L6Y0_TRYCR
406
1
46052
TrEMBL
other Location (Reliability: 2)
G2Q2U8_MYCTT
Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799)
375
1
41609
TrEMBL
other Location (Reliability: 4)
A0A1W2TDW9_ROSNE
369
0
40860
TrEMBL
other Location (Reliability: 4)
D7FKR6_ECTSI
348
1
38262
TrEMBL
other Location (Reliability: 3)
A0A8J0PJF2_XENTR
345
1
38927
TrEMBL
Mitochondrion (Reliability: 5)
A0A0B2R9X9_GLYSO
149
0
16209
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3G2S4H9_9BASI
476
1
53257
TrEMBL
other Location (Reliability: 2)
A0A7U3ZI89_RUNSL
Runella slithyformis (strain ATCC 29530 / DSM 19594 / LMG 11500 / NCIMB 11436 / LSU 4)
332
0
37000
TrEMBL
-
F0T1U5_SYNGF
Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR)
329
0
37328
TrEMBL
-
A0A2H9ZX18_9ASPA
350
0
38911
TrEMBL
Mitochondrion (Reliability: 5)
Q566U2_DANRE
345
1
38466
TrEMBL
Mitochondrion (Reliability: 2)
A0A2P6PBT1_ROSCH
480
4
53880
TrEMBL
other Location (Reliability: 3)
A0A0F8BTH9_CERFI
372
0
40567
TrEMBL
other Location (Reliability: 2)
A0A2U3QJK7_9BACT
317
0
34470
TrEMBL
-
G0QWJ3_ICHMG
Ichthyophthirius multifiliis (strain G5)
253
0
28658
TrEMBL
Mitochondrion (Reliability: 5)
G0QWJ3_ICHMG
White spot disease agent
253
0
28658
TrEMBL
Mitochondrion (Reliability: 5)
K0KBM1_WICCF
Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031 F-60-10)
348
0
38904
TrEMBL
Secretory Pathway (Reliability: 5)
D5PFS6_9MYCO
368
0
40192
TrEMBL
-
K9XUI3_STAC7
Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437)
1521
0
172594
TrEMBL
-
I3SNW0_MEDTR
479
3
54269
TrEMBL
other Location (Reliability: 3)
W1QJX5_OGAPD
Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1)
349
0
38722
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2I0ADF1_9ASPA
384
0
41885
TrEMBL
other Location (Reliability: 5)
A0A2G9GG27_9LAMI
477
6
53435
TrEMBL
other Location (Reliability: 5)
A0A212KTW6_9CHLA
333
0
36660
TrEMBL
-
A0A0N1HIU8_9ACTN
383
0
40452
TrEMBL
-
A0A0B2RS39_GLYSO
401
0
44397
TrEMBL
other Location (Reliability: 3)
A0A061HUT9_CRIGR
240
1
27253
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2I0AM64_9ASPA
480
3
53326
TrEMBL
other Location (Reliability: 2)
A0A142B9G9_9GAMM
368
0
41188
TrEMBL
-
A0A1W1HEJ0_9DELT
329
0
36210
TrEMBL
-
A0A0B2SUH0_GLYSO
480
3
53888
TrEMBL
other Location (Reliability: 2)
A0A8J5AQQ1_9ASCO
359
0
39536
TrEMBL
other Location (Reliability: 4)
A0A0D2JT94_9CHLO
236
0
25081
TrEMBL
Mitochondrion (Reliability: 3)
F9WZQ0_ZYMTI
Zymoseptoria tritici (strain CBS 115943 / IPO323)
385
0
42647
TrEMBL
other Location (Reliability: 2)
A0A8J5BDR5_9ASCO
357
0
39270
TrEMBL
other Location (Reliability: 4)
A0A0F4YEW5_TALEM
411
1
45674
TrEMBL
Secretory Pathway (Reliability: 3)
B9R8T2_RICCO
478
5
53538
TrEMBL
other Location (Reliability: 4)
A0A0B2PYF0_GLYSO
478
3
53844
TrEMBL
other Location (Reliability: 3)
M5C244_THACB
Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14)
420
0
45928
TrEMBL
other Location (Reliability: 2)
A0A2G9HLN1_9LAMI
425
2
46673
TrEMBL
Mitochondrion (Reliability: 4)
G8P103_GRAMM
Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8)
328
0
35585
TrEMBL
-
M2W461_GALSU
362
0
41040
TrEMBL
Mitochondrion (Reliability: 4)
A0A8J8W2W7_9EURO
412
0
45793
TrEMBL
Secretory Pathway (Reliability: 5)
A0A3S5H5P6_LEIDO
407
1
46073
TrEMBL
other Location (Reliability: 2)
F4KUF8_HALH1
Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O)
335
0
37023
TrEMBL
-
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
additional information
-
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
additional information
-
ERG26p structure homology modeling based on the crystal structure of Pseudomonas aeruginosa UDP-N-acetylglucosamine 4-epimerase complexed with UDP-N-acetylgalactosamine, PDB ID 1SB8
-
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospholipoprotein
-
presence of phosphatidylcholine and phosphatidylethanolamine, no loss of activity after removal of phospholipids