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Information on EC 1.1.1.117 - D-arabinose 1-dehydrogenase [NAD(P)+] and Organism(s) Saccharomyces cerevisiae and UniProt Accession P38115

for references in articles please use BRENDA:EC1.1.1.117
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IUBMB Comments
Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.
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This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P38115
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ARA1, D-arabinose dehydrogenase, dehydrogenase, D-arabinose (nicotinamide adenine dinucleotide (phosphate)), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-arabinose dehydrogenase
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dehydrogenase, D-arabinose (nicotinamide adenine dinucleotide (phosphate))
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
D-arabinose:NAD(P)+ 1-oxidoreductase
Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-48-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-arabinose + NADP+
D-arabinono-1,4-lactone + NADPH + H+
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-arabinose + NADP+
D-arabinono-1,4-lactone + NADPH + H+
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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a double mutant DELATbdh1 and DELTA ara1 strain still produces (2S,3S)-2,3-butanediol and meso-2,3-butanediol suggesting only a minor role of Ara1p in the production of 2,3-butanediol
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
x-ray crystallography
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
apo and NADPH-complexed enzyme forms, hanging drop vapor diffusion method, using 25% (w/v) polyethylene glycol 3350, 0.1 M HEPES pH 7.5
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography and Superdex 200 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hu, X.Q.; Guo, P.C.; Ma, J.D.; Li, W.F.
Structures of Saccharomyces cerevisiae D-arabinose dehydrogenase Ara1 and its complex with NADPH: implications for cofactor-assisted substrate recognition
Acta Crystallogr. Sect. F
69
1190-1195
2013
Saccharomyces cerevisiae (P38115)
Manually annotated by BRENDA team