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Synonyms
xylose reductase, l-xylulose reductase, dicarbonyl/l-xylulose reductase, nad(p)h-dependent xylose reductase, rplxr, nadp(+)-dependent xylitol dehydrogenase, rplxr3, nadp+-dependent xylitol dehydrogenase,
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xylitol + NADP+ = L-xylulose + NADPH + H+
xylitol + NADP+ = L-xylulose + NADPH + H+
probably identical with EC 1.1.1.5 diacetyl reductase
-
xylitol + NADP+ = L-xylulose + NADPH + H+
active site structure
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xylitol + NADP+ = L-xylulose + NADPH + H+
active site residues are Cys138, Val143, His146, Trp191, and Met200, the catalytic tetrad is formed by Asn107, Ser136, Tyr149, and Lys153, substrate binding site structure, enzyme with dual function showing L-xylulose reductase activity and dicarbonyl reductase activity, EC 1.1.1.5
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
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xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
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xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5
xylitol + NADP+ = L-xylulose + NADPH + H+
enzyme with dual function showing L-xylulose reductase and dicarbonyl reductase activities, it is probably identical with sperm 34 kDa protein P34H and diacetyl reductase, EC 1.1.1.5, the amino acid residues Ser136, Tyr149, and Lys153 form the catalytic triad
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xylitol + NADP+ = L-xylulose + NADPH + H+
immunological analysis revealed that the dicarbonyl/L-xylulose reductase is not identical with the sperm protein P26h
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xylitol + NADP+ = L-xylulose + NADPH + H+
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1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
1,4-dibromo-2,3-butanedione + NADPH
? + NADP+
-
dicarbonyl reductase activity
-
-
r
D-erythrose + NADPH + H+
? + NADP+
-
-
-
ir
D-fructose + NADPH + H+
? + NADP+
low activity
-
-
?
D-ribulose + NADH
D-arabinitol + NAD+
-
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
D-ribulose + NADPH + H+
? + NADP+
-
-
-
?
D-ribulose + NADPH + H+
D-ribitol + NADP+
-
-
-
-
?
D-sorbitol + NADP+
?
-
-
-
-
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
D-threose + NADPH
D-threitol + NADP+
D-threose + NADPH + H+
? + NADP+
-
-
-
ir
D-xylulose + NADH + H+
D-arabinitol + NAD+
D-xylulose + NADPH + H+
D-xylitol + NADP+
D-xylulose + NADPH + H+
xylitol + NADP+
diacetyl + NAD(P)H
acetoin + NAD(P)+
diacetyl + NADPH + H+
acetoin + NADP+
-
-
-
?
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
DL-threitol + NAD+
D-threose + NADH
DL-threitol + NADP+
D-erythrulose + NADPH
-
probably identical with erythrulose reductase, EC 1.1.1.162 and diacetyl reductase, EC 1.1.1.5
-
r
L-erythrulose + NADPH + H+
? + NADP+
-
-
-
ir
L-ribulose + NADPH + H+
? + NADP+
low activity
-
-
?
L-sorbose + NADPH + H+
L-sorbitol + NADP+
L-threose + NADPH
L-threitol + NADP+
L-xylulose + NADH
L-xylitol + NAD+
L-xylulose + NADH + H+
xylitol + NAD+
L-xylulose + NADPH + H+
L-xylitol + NADP+
L-xylulose + NADPH + H+
xylitol + NADP+
xylitol + NAD+
L-xylulose + NADH + H+
xylitol + NADP+
L-xylulose + NADPH + H+
xylitol + NADP+
xylulose + NADPH + H+
-
-
-
?
additional information
?
-
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
-
-
r
1,4-dibromo-2,3-butanedione + NAD(P)H
? + NAD(P)+
dicarbonyl reductase activity, best substrate, NADPH is the preferred cofactor, forward reaction is preferred
-
-
r
D-erythrose + NADPH
?
reductase activity
-
-
r
D-erythrose + NADPH
?
reductase activity
-
-
r
D-erythrose + NADPH
?
reductase activity
-
-
r
D-erythrose + NADPH
?
reductase activity
-
-
r
D-erythrose + NADPH
?
reductase activity
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
reductase activity
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
reductase activity
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
reductase activity
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
reductase activity
-
-
r
D-ribulose + NADPH
D-ribitol + NADP+
-
-
-
-
?
D-ribulose + NADPH
D-ribitol + NADP+
reductase activity
-
-
r
D-sorbitol + NADP+
D-sorbose + NADPH + H+
-
-
-
?
D-sorbitol + NADP+
D-sorbose + NADPH + H+
-
-
-
?
D-threose + NADPH
D-threitol + NADP+
reductase activity
-
-
r
D-threose + NADPH
D-threitol + NADP+
reductase activity
-
-
r
D-threose + NADPH
D-threitol + NADP+
reductase activity
-
-
r
D-threose + NADPH
D-threitol + NADP+
reductase activity
-
-
r
D-threose + NADPH
D-threitol + NADP+
reductase activity
-
-
r
D-xylulose + NADH + H+
D-arabinitol + NAD+
about 100fold lower activity compared to L-xylulose
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-
r
D-xylulose + NADH + H+
D-arabinitol + NAD+
-
-
-
?
D-xylulose + NADPH + H+
D-xylitol + NADP+
reductase activity
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
reductase activity
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
reductase activity
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
reductase activity
-
-
r
D-xylulose + NADPH + H+
D-xylitol + NADP+
reductase activity
-
-
r
D-xylulose + NADPH + H+
xylitol + NADP+
-
-
-
?
D-xylulose + NADPH + H+
xylitol + NADP+
low activity
-
-
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity, NADPH is the preferred cofactor
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
dicarbonyl reductase activity
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity, NADPH is the preferred cofactor
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity, NADPH is the preferred cofactor
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
-
-
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
dicarbonyl reductase activity
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity, NADPH is the preferred cofactor
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
-
-
?
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
detoxification of alpha-dicarbonyl compounds
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-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
-
dicarbonyl reductase activity
-
-
r
diacetyl + NAD(P)H
acetoin + NAD(P)+
dicarbonyl reductase activity, NADPH is the preferred cofactor
-
-
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
reductase activity, forward reaction is highly preferred
-
-
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
reductase activity, forward reaction is highly preferred
-
-
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
reductase activity, forward reaction is highly preferred
-
-
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
reductase activity, forward reaction is highly preferred
-
-
r
DL-glyceraldehyde + NADPH
dihydroxyacetone + NADP+
reductase activity, forward reaction is highly preferred
-
-
r
DL-threitol + NAD+
D-threose + NADH
-
-
-
?
DL-threitol + NAD+
D-threose + NADH
-
-
-
?
DL-threitol + NAD+
D-threose + NADH
-
-
-
?
DL-threitol + NAD+
D-threose + NADH
-
-
-
r
L-erythrulose + NADPH
?
reductase activity
-
-
r
L-erythrulose + NADPH
?
reductase activity
-
-
r
L-erythrulose + NADPH
?
reductase activity
-
-
r
L-erythrulose + NADPH
?
reductase activity
-
-
r
L-erythrulose + NADPH
?
reductase activity
-
-
r
L-sorbose + NADPH + H+
L-sorbitol + NADP+
low activity
-
-
?
L-sorbose + NADPH + H+
L-sorbitol + NADP+
low activity
-
-
?
L-threose + NADPH
L-threitol + NADP+
reductase activity
-
-
r
L-threose + NADPH
L-threitol + NADP+
reductase activity
-
-
r
L-threose + NADPH
L-threitol + NADP+
reductase activity
-
-
r
L-threose + NADPH
L-threitol + NADP+
reductase activity
-
-
r
L-threose + NADPH
L-threitol + NADP+
reductase activity
-
-
r
L-xylulose + NADH
L-xylitol + NAD+
-
-
-
r
L-xylulose + NADH
L-xylitol + NAD+
part of the L-arabinose catabolism
-
-
r
L-xylulose + NADH + H+
xylitol + NAD+
-
-
-
r
L-xylulose + NADH + H+
xylitol + NAD+
-
-
-
r
L-xylulose + NADH + H+
xylitol + NAD+
-
-
-
r
L-xylulose + NADH + H+
xylitol + NAD+
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
also reduces 2,3-butadione
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
part of the glucuronic acid pathway, enzyme may be involved in water reabsorption and cellular osmoregulation
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
the enzyme is involved in the uronate cycle of glucose metabolism
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
L-xylulose reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
uronate cycle of glucose metabolism
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
uronate cycle of glucose metabolism
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
part of the uronate cycle, involved in osmoregulation in the kidney
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
L-xylulose reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
reductase activity
-
-
r
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
uronate cycle of glucose metabolism
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
xylulose reductase has about 50% higher activity during xylose consumption than during the coconsumption of glucose and xylose
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
uronate cycle of glucose metabolism
-
-
?
L-xylulose + NADPH + H+
L-xylitol + NADP+
-
-
-
-
?
L-xylulose + NADPH + H+
xylitol + NADP+
-
-
-
ir
L-xylulose + NADPH + H+
xylitol + NADP+
-
-
-
r
L-xylulose + NADPH + H+
xylitol + NADP+
preferred substrate
-
-
r
L-xylulose + NADPH + H+
xylitol + NADP+
preferred substrate
-
-
r
xylitol + NAD+
L-xylulose + NADH + H+
-
-
-
r
xylitol + NAD+
L-xylulose + NADH + H+
-
-
-
r
xylitol + NAD+
L-xylulose + NADH + H+
-
-
-
r
xylitol + NAD+
L-xylulose + NADH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
-
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
-
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
?
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
-
-
-
r
xylitol + NADP+
L-xylulose + NADPH + H+
1.1.1.10 L-xylulose reductase
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