Ligand xylitol

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Basic Ligand Information

Molecular Structure
Picture of xylitol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H12O5
xylitol
HEBKCHPVOIAQTA-SCDXWVJYSA-N
Synonyms:
D-xylitol, L-xylitol


Show all pahtways known for Show all BRENDA pathways known for xylitol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xylitol + NADP+ = L-xylulose + NADPH + H+
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xylitol + NAD+ = D-xylulose + NADH + H+
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xylitol + NAD+ = ? + NADH
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xylitol + NAD+ = L-xylulose + NADH + H+
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xylitol + NAD+ = L-xylulose + NADH + H+
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xylitol + NADP+ = D-xylulose + NADPH + H+
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xylitol + O2 = ?
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xylitol + ? = xylitol 5-phosphate + ?
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In Vivo Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-xylulose + NADH + H+ = xylitol + NAD+
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D-xylitol-5-phosphate + H2O = D-xylitol + phosphate
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Substrate in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+
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xylitol + NAD+ = D-xylulose + NADH
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D-xylitol + NADP+ = D-xylose + NADPH + H+
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xylitol + NAD+ = L-xylulose + NADH + H+
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xylitol + NAD+ = D-xylulose + NADH + H+
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xylitol + NAD+ = L-xylulose + NADH + H+
show the reaction diagram
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xylitol + NADP+ = D-xylulose + NADPH + H+
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xylitol + O2 = ?
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xylitol + phenazine methosulfate = ?
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xylitol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
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xylitol + ? = xylitol 5-phosphate + ?
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xylitol + H2O = ?
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Product in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
xylose + NADPH + H+ = xylitol + NADP+
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D-xylose + NADPH + H+ = D-xylitol + NADP+
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D-xylulose + NADH + H+ = D-xylitol + NAD+
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D-xylose + NADPH = xylitol + NADP+
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D-xylulose + NADH + H+ = xylitol + NAD+
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D-glucose + D-xylose = D-gluconolactone + D-xylitol
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D-xylitol-5-phosphate + H2O = D-xylitol + phosphate
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4-O-methyl-D-glucuronosyl-xylitol + H2O = 4-O-methyl-D-glucuronate + xylitol
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Activator in Enzyme-catalyzed Reactions (18 results)

Inhibitor in Enzyme-catalyzed Reactions (75 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non-competitive against NADH and D-xylose
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competitive
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inhibitory action at 35 and 40% solution
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competitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (55 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (44 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.63
-
wild-type, pH 10.0
177.2
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pH 8.5, 25°C
36
-
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2.75
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pH 10.0, 40°C
13
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pH 7.5, 30°C
15
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pH 7.5, 70°C, wild-type enzyme
237
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wild type enzyme

KM Value (107 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
18.5
-
pH 8.5, 25°C
2.06
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pH 10.0, 40°C
130
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recombinant mutant D205A/I206R, pH 9.0, 35°C, with NADP+
0.32
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pH 7.5, 30°C
0.00009
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pH 7.5, 70°C, wild-type enzyme
127
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wild type enzyme

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for xylitol

ChEBI
PubChem
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PubChem