2.4.1.206: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase This is an abbreviated version! For detailed information about lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase, go to the full flat file .
Word Map on EC 2.4.1.206
Reaction
UDP-N-acetyl-alpha-D-glucosamine +
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide =
UDP +
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Synonyms acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide beta-, beta1,3 N-acetylglucosaminyltransferase GlcNAc(beta1,3)Gal(beta1,4)Glc-ceramide synthase, beta1,3-N-acetylglucosaminyltransferase-2, beta1-3-N-acetylglucosaminyltransferase, beta3Gn-T2, beta3Gn-T5, beta3GnT5, GlcNAc transferase, LA2 synthase, LacCer(beta1,3)N-acetylglucosaminyltransferase, lactosylceramide beta-acetylglucosaminyltransferase, lactosylceramide: N-acetylglucosaminyltransferase, lactosylceramide:N-acetylglucosaminyltransferase, lactotriaosylceramide synthase, Lc2Cer-Glc-NAc-Tr, Lc3 synthase, Lc3 synthase/bGn-T5, UDP-GlcNAc:lactosylceramide beta1,3-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase
ECTree
Source Tissue
Source Tissue on EC 2.4.1.206 - lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
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splenic
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not epithelial cells
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the enzyme is expressedin two distinct phases during the zebrafish embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens. Hedgehog signaling is required for the Lc3 synthase expression in embryonic lens
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very low content
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low content
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Daoy and D341 Med, cultured both in vitro and as xenografts in nude mice
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low content
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expression during embryonic brain development
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and dendrites
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distinct cellular layers: Purkinje cell layer, molecular cell layer, granule cell layer + white matter
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neonatal
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distinct cellular layers: Purkinje cell layer, molecular cell layer, granule cell layer + white matter
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fetal
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fetal
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not adult
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the enzyme is expressed in two distinct phases during the zebrafish embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens
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expression during mouse development
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E17 fetus, both head and body show strong expression of Lc3 synthase in wild-type (Wt/Wt) and heterozygous (Wt/KO) mice
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E17 fetus, both head and body show strong expression of Lc3 synthase in wild-type (Wt/Wt) and heterozygous (Wt/KO) mice
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additional information
transcript content and activity in diverse tumour cell lines, overview, nearly undetectable content in leukemic cell lines
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additional information
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transcript content and activity in diverse tumour cell lines, overview, nearly undetectable content in leukemic cell lines
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additional information
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not in colonic epithelial cells
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additional information
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enzyme levels in brain regions during pre- and postnatal brain development
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additional information
enzyme levels in brain regions during pre- and postnatal brain development
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additional information
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retinoic acid activates the enzyme and leads to developmental malformations of the embryos, overview
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