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Literature summary for 2.4.1.206 extracted from

  • Holmes, E.H.; Hakomori, S.i.; Ostrander, G.K.
    Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1-3N-acetylglucosaminyltransferase (1987), J. Biol. Chem., 262, 15649-15658.
    View publication on PubMed
Search for more literature for 2.4.1.206

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + lactosylceramide Homo sapiens may play a key role in regulating the level of various types of lactoseries tumor-associated antigens with the lacto type 1 or 2 chain UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic adenocarcinoma cell
-
 Homo sapiens
-
colonic mucosa not epithelial cells Homo sapiens
-
additional information not in colonic epithelial cells Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in different cell lines of normal colonic mucosa and colonic adenocarcinoma Homo sapiens
0.00000034
-
 colonic mucosa Homo sapiens
0.0000046
-
 colonic adenocarcinoma tissue sample Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + D-galactosyl-1,4-beta-D-glucosylceramide i.e. lactosylceramide Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?
UDP-N-acetyl-D-glucosamine + lactosylceramide may play a key role in regulating the level of various types of lactoseries tumor-associated antigens with the lacto type 1 or 2 chain Homo sapiens UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens