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2.1.1.227: 16S rRNA (cytidine1409-2'-O)-methyltransferase

This is an abbreviated version!
For detailed information about 16S rRNA (cytidine1409-2'-O)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
cytidine1409 in 16S rRNA
=
S-adenosyl-L-homocysteine
+
2'-O-methylcytidine1409 in 16S rRNA

Synonyms

2'-O-methyltransferase, More, rRNA methylase, rRNA methylase TlyA, TlyA, TlyAII

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.227 16S rRNA (cytidine1409-2'-O)-methyltransferase

Expression

Expression on EC 2.1.1.227 - 16S rRNA (cytidine1409-2'-O)-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in response to capreomycin, cells downregulate TlyA-mediated methylation of 16S and 23S (cf. EC 2.1.1.226) rRNA resulting in decreased drug susceptibility. Incubation with capreomycin during bacterial growth results in a reduced post-transcriptional modification of rRNA at TlyA-dependent sites (1409 in 16S and 1920 in 23S)
the common resistance mutation A1408G is accompanied by a physiological change that involves increased expression of the tlyA gene