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EC Number	Expression	Commentary	Reference
2.1.1.227	down	in response to capreomycin, cells downregulate TlyA-mediated methylation of 16S and 23S (cf. EC 2.1.1.226) rRNA resulting in decreased drug susceptibility. Incubation with capreomycin during bacterial growth results in a reduced post-transcriptional modification of rRNA at TlyA-dependent sites (1409 in 16S and 1920 in 23S)	-, 758323
2.1.1.227	up	the common resistance mutation A1408G is accompanied by a physiological change that involves increased expression of the tlyA gene	-, 758323

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Release 2023.1 (January 2023)