1.2.1.82: beta-apo-4'-carotenal oxygenase
This is an abbreviated version!
For detailed information about beta-apo-4'-carotenal oxygenase, go to the full flat file.
Word Map on EC 1.2.1.82
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1.2.1.82
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neurospora
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crassa
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carotenoid
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apocarotenoids
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neurosporaxanthin
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carotenogenesis
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torulene
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cross-pathway
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apocarotenals
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yellow
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carotene
- 1.2.1.82
- neurospora
- crassa
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carotenoid
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apocarotenoids
- neurosporaxanthin
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carotenogenesis
- torulene
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cross-pathway
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apocarotenals
- yellow
- carotene
Reaction
Synonyms
CarD, YLO-1
ECTree
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General Information
General Information on EC 1.2.1.82 - beta-apo-4'-carotenal oxygenase
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physiological function
dominating carotenoids in the Ylo mutant are 4'-apolycopene-4'-myristate and 4'-apo-gamma-carotene-4'-myristate. In vivo, the aldehyde intermediates 4'-apo-gamma-carotene-4'-al and 4'-apo-lycopene-4'-al do not accumulate substantially but are reduced instead to the corresponding alcohols, 4'-apolycopene-4'-ol and 4'-apo-gamma-carotene-4'-ol, and both further esterified with mainly myristic acid yielding 4'-apolycopene-4'-myristate and 4'-apo-gamma-carotene-4'-myristate
physiological function
enzyme is involved in the biosynthetic pathway to neurosporaxanthin. First step is the cleavage of 3,4-didehydrolycopene into apo-4'-lycopenal by Cao2, which is then oxidized by YLO-1 to yield apo-4'-lycopenoic acid, the last intermediate in the pathway. The final step is then catalyzed by the cyclase activity of AL-2. An Ylo-1 mutant accumulates three major pigments, i.e. lycopene, apo-4'-lycopenal and apo-4'-lycopenol. The pigments accumulating in the Ylo-1 mutant are non-cyclic and represent lycopene and apolycopenoids, indicating that the in vivo substrate of Ylo-1 is apo-4'-lycopenal rather than its cyclic isomer beta-apo-4'-carotenal
physiological function
targeted disruption of CarD in a Gibberella fujikuroi carotenoid-overproducing strain results in the loss of neurosporaxanthin and the accumulation of beta-apo-4'-carotenal, its derivative beta-apo-4'-carotenol, and minor amounts of other carotenoids. Strains harboring the CarD mutation acquire a yellowish pigmentation
physiological function
Ylo-1 mutant strain exhibits a yellow colour, lacks neurosporaxanthin and accumulates several carotenes