1.14.15.26: toluene methyl-monooxygenase

This is an abbreviated version!
For detailed information about toluene methyl-monooxygenase, go to the full flat file.

Reaction

+ 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ =

+ 2 oxidized ferredoxin [iron-sulfur] cluster +

Synonyms

ntnM, xylM

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.26 toluene methyl-monooxygenase

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2	AA Sequence
2	Application
1	Cofactor
3	General Information
1	General Stability
2	Localization
1	Metals/Ions
6	Organism
10	Pathway
1	pH Optimum
1	Purification (Commentary)
3	Reaction
6	Reference
17	Substrates and Products (Substrate)
5	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.15.26 - toluene methyl-monooxygenase

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methylbenzene,ferredoxin:oxygen oxidoreductase (methyl-hydroxylating)

The enzyme, characterized from several Pseudomonas strains, catalyses the first step in the degradation of toluenes and xylenes. It has a broad substrate specificity and is also active with substituted compounds, such as chlorotoluenes. The electrons are provided by a reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase) that transfers electrons from NADH via FAD and an [2Fe-2S] cluster. The enzyme can also act on its products, producing gem-diols that spontaneously dehydrate to form aldehydes.