1.14.14.24: vitamin D 25-hydroxylase

This is an abbreviated version!
For detailed information about vitamin D 25-hydroxylase, go to the full flat file.

Reaction

Synonyms

CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.24 vitamin D 25-hydroxylase

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Results	in table
5	Activating Compound
8	AA Sequence
5	Application
13	Cloned(Commentary)
14	Cofactor
2	Crystallization (Commentary)
606	Disease/ Diagnostics
5	Expression
12	General Information
4	Inhibitors
22	KM Value [mM]
16	Localization
1	Metals/Ions
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	pH Optimum
18	Protein Variants
2	Purification (Commentary)
1	Reaction
26	Reference
26	Source Tissue
1	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
6	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
13	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.14.14.24 - vitamin D 25-hydroxylase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

bovine serum albumin

Rattus norvegicus

-

stimulation

717287

-

KCl

Pseudonocardia autotrophica

C4B644

or NaCl, required. Optimum concentration 100 mM

717180

NaCl

Pseudonocardia autotrophica

C4B644

or KCl, required. Optimum concentration 100 mM

717180

partially methylated beta-cyclodextrin

Pseudonocardia autotrophica

C4B644

activity increases approximately 10fold when partially methylated beta-cyclodextrin is present in the reaction at a final concentration of 0.05%

717180

-

additional information

Rattus norvegicus

-

stimulation by addition of cytosolic protein, which remains after boiling the cytosolic protein

717287

-