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Information on EC 1.14.14.24 - vitamin D 25-hydroxylase

for references in articles please use BRENDA:EC1.14.14.24

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IUBMB Comments

A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo . The direct electron donor to the enzyme is EC 1.6.2.4, NADPH—hemoprotein reductase.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
cyp2r1, cyp2j3, vitamin d 25-hydroxylase, cytochrome p450 2c11, cytochrome p450 2j2, cyp2d25, vitamin d-25-hydroxylase, cytochrome p450 2r1, cytochrome p450 2j3, vitamin d2 25-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
calciol + O2 + [reduced NADPH-hemoprotein reductase] = calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
vitamin D3 biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links