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Information on EC 1.14.14.24 - vitamin D 25-hydroxylase

for references in articles please use BRENDA:EC1.14.14.24
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IUBMB Comments
A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo . The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cyp2r1, cyp2j3, cytochrome p450 2c11, cyp2d25, cytochrome p450 2j2, vitamin d-25-hydroxylase, cytochrome p450 2r1, vitamin d2 25-hydroxylase, cytochrome p450 2j3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
calciol + O2 + [reduced NADPH-hemoprotein reductase] = calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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