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1.14.13.233: 4-hydroxy-6-methylpretetramide 12a-monooxygenase

This is an abbreviated version!
For detailed information about 4-hydroxy-6-methylpretetramide 12a-monooxygenase, go to the full flat file.

Reaction

4-hydroxy-6-methylpretetramide
+
NADPH
+
H+
+
O2
=
4-de(dimethylamino)-4-oxoanhydrotetracycline
+
NADP+
+
H2O

Synonyms

oxyL

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase

Reference

Reference on EC 1.14.13.233 - 4-hydroxy-6-methylpretetramide 12a-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, P.; Zhang, W.; Zhan, J.; Tang, Y.
Identification of oxyE as an ancillary oxygenase during tetracycline biosynthesis
ChemBioChem
10
1544-1550
2009
Streptomyces rimosus (Q3S8Q4), Streptomyces rimosus ATCC 10970 (Q3S8Q4)
Manually annotated by BRENDA team
Zhang, W.; Watanabe, K.; Cai, X.; Jung, M.; Tang, Y.; Zhan, J.
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis
J. Am. Chem. Soc.
130
6068-6069
2008
Streptomyces rimosus (Q3S8Q4), Streptomyces rimosus ATCC 10970 (Q3S8Q4)
Manually annotated by BRENDA team