Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 | Streptomyces rimosus | - |
4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O | - |
? | |
4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 | Streptomyces rimosus ATCC 10970 | - |
4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces rimosus | Q3S8Q4 | bifunctional enzyme, hydroxylates 6-methylpretetramide at both the C-12a and C-4 positions, i.e. reactions of EC 1.14.13.232 and EC 1.14.1.3.233 | - |
Streptomyces rimosus ATCC 10970 | Q3S8Q4 | bifunctional enzyme, hydroxylates 6-methylpretetramide at both the C-12a and C-4 positions, i.e. reactions of EC 1.14.13.232 and EC 1.14.1.3.233 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 | - |
Streptomyces rimosus | 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O | - |
? | |
4-hydroxy-6-methylpretetramide + NADPH + H+ + O2 | - |
Streptomyces rimosus ATCC 10970 | 4-de(dimethylamino)-4-oxoanhydrotetracycline + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
oxyL | - |
Streptomyces rimosus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Streptomyces rimosus |
General Information | Comment | Organism |
---|---|---|
physiological function | a gene disruption mutant reveals the complete disappearance of oxytetracycline, with the concomitant appearance of a predominant glycoside metabolite derived from 4-hydroxy-6-methylpretetramid | Streptomyces rimosus |