1.14.12.22: carbazole 1,9a-dioxygenase
This is an abbreviated version!
For detailed information about carbazole 1,9a-dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.22
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1.14.12.22
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ferredoxin
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rieske
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resinovorans
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carac
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carbazole-degradation
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dibenzo-p-dioxins
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dibenzofurans
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fluorene
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aromaticivorans
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nocardioides
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dianhydride
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dibenzothiophene
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polyimide
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janthinobacterium
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stipes
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degradation
- 1.14.12.22
- ferredoxin
-
rieske
- resinovorans
- carac
-
carbazole-degradation
- dibenzo-p-dioxins
- dibenzofurans
- fluorene
- aromaticivorans
-
nocardioides
-
dianhydride
- dibenzothiophene
-
polyimide
- janthinobacterium
-
stipes
- degradation
Reaction
Synonyms
CarAa, CarAc, carbazole dioxygenase, CARDO, CARDO-F, CARDO-R
ECTree
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Systematic Name
Systematic Name on EC 1.14.12.22 - carbazole 1,9a-dioxygenase
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9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating)
This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2'-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster.