1.14.11.26: deacetoxycephalosporin-C hydroxylase
This is an abbreviated version!
For detailed information about deacetoxycephalosporin-C hydroxylase, go to the full flat file.
Word Map on EC 1.14.11.26
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1.14.11.26
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clavuligerus
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penicillin
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dithiothreitol
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ascorbate
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acremonium
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alpha-ketoglutarate
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chrysogenum
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ring-expansion
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n-ethylmaleimide
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expandase
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cephalosporium
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synthesis
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biotechnology
- 1.14.11.26
- clavuligerus
- penicillin
- dithiothreitol
- ascorbate
- acremonium
- alpha-ketoglutarate
- chrysogenum
-
ring-expansion
- n-ethylmaleimide
-
expandase
-
cephalosporium
- synthesis
- biotechnology
Reaction
Synonyms
cefF, Cephalosporin biosynthesis expandase/hydroxylase, DACS, DAOC hydroxylase, DAOC synthase, DAOC/DAC synthase, DAOCS, deacetoxycephalosporin C hydroxylase, deacetoxycephalosporin C synthase, deacetylcephalosporin C synthase
ECTree
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Inhibitors
Inhibitors on EC 1.14.11.26 - deacetoxycephalosporin-C hydroxylase
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(2S,4S,6R,7R)-1-aza-7-((5R)-5-carboxypentanamidol)-4-methyl-8-oxo-5-thiatricyclo-(4,2,0,0)octane-2-carboxylate
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reversible, 0.04 mM, 90% inhibition
Penicillin N
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1 mM, 62% inhibition, competitive with deacetoxycephalosporin C
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1 mM, 100% inhibition of hydroxylation reaction, EC 1.14.11.26
5,5'-dithiobis-2-nitrobenzoic acid
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reactivation by dithiothreitol
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0.6 mM, 83% inhibition of hydroxylation reaction, EC 1.14.11.26
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1 mM, 2% inhibition of hydroxylation reaction, EC 1.14.11.26
N-ethylmaleimide
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1 mM, 97% inhibition of hydroxylation reaction, EC 1.14.11.26
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0.6 mM, 100% inhibition of hydroxylation reaction, EC 1.14.11.26
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1 mM, 100% inhibition of hydroxylation reaction, EC 1.14.11.26