EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.B4 | E223A |
catalytically inactive |
733819 |
| 3.4.24.B4 | F55S |
naturally occuring dominant mutation and cloning by site-directed mutagenesis, the mutation is involved in metaphyseal anadysplasia |
710801 |
| 3.4.24.B4 | H213N |
naturally occuring recessive mutation and cloning by site-directed mutagenesis, the mutation is involved in metaphyseal anadysplasia |
710801 |
| 3.4.24.B4 | M1K |
naturally occuring recessive mutation and cloning by site-directed mutagenesis, the mutation is involved in metaphyseal anadysplasia |
710801 |
| 3.4.24.B4 | M72T |
naturally occuring dominant mutation and cloning by site-directed mutagenesis, the mutation is involved in metaphyseal anadysplasia |
710801 |
| 3.4.24.B4 | more |
enzyme-null mice show profound defects in growth plate cartilage with markedly increased hyperthrophic domains and delay in indochondrial ossification and formation and vascularization of primary ossification centers. Cartilaginous growth plate abnormalities persist in adult animals and phenocopy defects observed in human hereditary chondrodysplasis |
670661 |
| 3.4.24.B4 | more |
generation of a -148 rat MMP-13 promoter construct and a mutation construct of pGL2-MMP-13 promoter by site-directed mutagenesis. MMP-13 knockout by siRNA in UMR106-01 cells |
712498 |
| 3.4.24.B4 | more |
generation of MMP13 and MMP13/MMP9 knockout mice, that all show delayed wound closure compared to wild-type mice. The rate of re-epithelialization is significantly delayed in MMP-9 KO and MMP-13 KO mice and remarkably delayed in MMP-9/13 double KO mice, phenotype, overview |
710806 |
| 3.4.24.B4 | more |
hypoxia-induced MMP-13 overexpression is antagonized by transfection with antisense oligodeoxynucleotides of c-Fos or c-Jun. Transfection of MMP-13-shRNA markedly antagonizes the proteolysis of ZO-1 induced by hypoxic-conditioned medium |
712559 |
| 3.4.24.B4 | more |
identification of MMP-13 promoter polymorphisms in severe, generalized chronic periodontitis patients, genotypes and gingival crevicular fluid MMP-13 level with MMP-13 genotype correlation, overview |
712577 |
