EC Number   |
Protein Variants |
Reference |
|---|
   3.4.24.B18 | A510V |
subunit paraplegin, function impaired, naturally occuring pathogenic mutation |
712130 |
| 3.4.24.B18 | D634A |
catalytically inactive |
679501 |
| 3.4.24.B18 | D689A |
catalytically inactive |
679501 |
| 3.4.24.B18 | E359A |
the mutant lacks ATPase activity but retains casein lytic protease activity |
734573 |
| 3.4.24.B18 | E388Q/E448Q |
an ATP hydrolysis-deficient m-AAA protease variant. The mutant effectively traps ATP and keeps m-AAA protease subunits in one nucleotide conformation |
719994 |
| 3.4.24.B18 | E408Q |
subunit AFG3L2, within Walker B motif, cells expressing AFG3L2 (E408Q) show a prominent reduction of their growth rate |
712541 |
| 3.4.24.B18 | E559Q |
exerts only about 10% of wild type activity |
679501 |
| 3.4.24.B18 | E559Q |
inactive mutant |
651889 |
| 3.4.24.B18 | E559Q |
of subunit Yta10, enzyme is still capable of substrate binding but lacks proteolytic activity |
668180 |
| 3.4.24.B18 | E559Q/E614Q |
inactive |
719365 |
