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Literature summary for 3.4.24.B18 extracted from

  • Lowth, B.; Kirstein-Miles, J.; Saiyed, T.; Brötz-Oesterhelt, H.; Morimoto, R.; Truscott, K.; Dougan, D.
    Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX (2012), J. Struct. Biol., 179, 193-201.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E359A the mutant lacks ATPase activity but retains casein lytic protease activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-casein + H2O best substrate Homo sapiens ?
-
?
beta-casein + H2O
-
Homo sapiens ?
-
?
kappa-casein + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
hexamer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
ClpX
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens