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Literature summary for 3.4.24.B18 extracted from

  • Savel'ev, A.S.; Novikova, L.A.; Kovaleva, I.E.; Luzikov, V.N.; Neupert, W.; Langer, T.
    ATP-dependent proteolysis in mitochondria. m-AAA protease and PIM1 protease exert overlapping substrate specificities and cooperate with the mtHsp70 system (1998), J. Biol. Chem., 273, 20596-20602.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E559Q inactive mutant Saccharomyces cerevisiae
E614Q inactive mutant Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Saccharomyces cerevisiae 16020
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Saccharomyces cerevisiae degradation of mislocalized proteins in the mitochodria peptides
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
proteolytic degradation of proteins enzyme shows overlapping substrate specificity with the ATP-dependent PIM1 protease located in the mitochondrial matrix Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apocytochrome P450scc + H2O bovine protein substrate from adrenal cortex mitochondrial inner membrane, imported in vitro into isolated yeast mitochondrial membrane, due to an N-terminal fusion to a heterologous transmembrane region Saccharomyces cerevisiae ?
-
?
protein + H2O
-
Saccharomyces cerevisiae peptides
-
?
protein + H2O degradation of mislocalized proteins in the mitochodria Saccharomyces cerevisiae peptides
-
?

Synonyms

Synonyms Comment Organism
M41.003 Merops-ID Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Saccharomyces cerevisiae