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Literature summary for 3.4.24.B18 extracted from

  • Ehses, S.; Raschke, I.; Mancuso, G.; Bernacchia, A.; Geimer, S.; Tondera, D.; Martinou, J.C.; Westermann, B.; Rugarli, E.I.; Langer, T.
    Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1 (2009), J. Cell Biol., 187, 1023-1036.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B18

Cloned(Commentary)

Cloned (Comment) Organism
subunit AFG3L2, expressed in HEK-293 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
E408Q subunit AFG3L2, within Walker B motif, cells expressing AFG3L2 (E408Q) show a prominent reduction of their growth rate Homo sapiens
E575Q subunit AFG3L2, within proteolytic site, no effect on growth rate Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Mus musculus 5743
-
mitochondrial inner membrane
-
 Homo sapiens 5743
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y4W6
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-
osteosarcoma cell cell line 143B Homo sapiens
-

Subunits

Subunits Comment Organism
More variable assembly of the subunits paraplegin, AFG3L1 and AFG3L2 Mus musculus
More variable assembly of the subunits subunits AFG3L2 and paraplegin Homo sapiens

Synonyms

Synonyms Comment Organism
m-AAA protease
-
 Mus musculus
m-AAA protease
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function regulates OPA1 cleavage in mitochondrial inner membrane Mus musculus
physiological function regulates OPA1 cleavage in mitochondrial inner membrane Homo sapiens