EC Number |
Cofactor |
Reference |
---|
4.6.1.2 | ATP |
activates at lower concentrations ,0.1 mM |
34832, 34841 |
4.6.1.2 | ATP |
ATP activates guanylyl cyclase isoforms GC-A and GC-B. 0.01 mM Go6976 increases the potency of ATP for isoform GC-B 4fold |
715634 |
4.6.1.2 | Calmodulin |
activation in presence of Ca2+ |
34828 |
4.6.1.2 | heme |
- |
666248, 690364, 691002, 691656, 693826, 694270, 714249, 715038, 715634, 715825, 716928, 730682, 730897 |
4.6.1.2 | heme |
hallmark of sGC activation by NO is the release of beta1 His105 from the heme, leading to allosteric stimulation of cyclase activity |
693096 |
4.6.1.2 | heme |
heat shock protein 90 is required to drive heme insertion into the enzyme and complete ist maturation |
730811 |
4.6.1.2 | heme |
heme depletion leads to inhibition of enzyme activation by NO |
684348 |
4.6.1.2 | heme |
heme domain is localized to the N-terminal 194 residues of the beta1 subunit. Characterization of the minimum functional ligand-binding heme domain derived from soluble guanylate cyclase |
664082 |
4.6.1.2 | heme |
in soluble guanylate cyclases |
691519 |
4.6.1.2 | heme |
NO-independent, heme-dependent soluble guanylate cyclase |
692545 |