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Literature summary for 4.6.1.2 extracted from

  • Winger, J.A.; Derbyshire, E.R.; Lamers, M.H.; Marletta, M.A.; Kuriyan, J.
    The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase (2008), BMC Struct. Biol., 8, 42.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information guanylate cyclase activation mechanism, overview Chlamydomonas reinhardtii
NO
-
 Chlamydomonas reinhardtii

Cloned(Commentary)

Cloned (Comment) Organism
gene CYG12 encodes the soluble isozyme Chlamydomonas reinhardtii

Crystallization (Commentary)

Crystallization (Comment) Organism
isolated dimeric and inactive catalytic domain, X-ray diffraction structure determination and analysis at 2.55 A resolution Chlamydomonas reinhardtii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information the soluble enzyme has two active sites in the dimer exhibiting positive cooperativity with a Hill coefficient of about 1.5 Chlamydomonas reinhardtii

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble soluble guanylate cyclase Chlamydomonas reinhardtii
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ most effective, Mg2+ activates to 1% of the activity with Mn2+ Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Chlamydomonas reinhardtii
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii Q5YLC2 soluble isozyme; gene CYG12 encoding the soluble isozyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Chlamydomonas reinhardtii 3',5'-cyclic GMP + diphosphate
-
 ?
additional information structure-function relationship, mechanism, modelling, overview Chlamydomonas reinhardtii ?
-
 ?

Subunits

Subunits Comment Organism
dimer catalytic domain, crystal structure, structure analysis and comparison, e.g. of helix alpha1, modelling, overview Chlamydomonas reinhardtii

Synonyms

Synonyms Comment Organism
soluble guanylate cyclase
-
 Chlamydomonas reinhardtii

Cofactor

Cofactor Comment Organism Structure
heme in soluble guanylate cyclases Chlamydomonas reinhardtii