EC Number |
General Information |
Reference |
---|
3.4.21.4 | malfunction |
infection of Lutzomyia longipalpis with Leishmania mexicana reduces trypsin-like activity in the sand fly midgut. Inhibition of trypsin expression by RNAi enhances the survival of Leishmania mexicana in Lutzomyia longipalpis, overview |
710193 |
3.4.21.4 | malfunction |
trypsin from pancreatic acinar cells destroys islets. Thus pancreatic slet transplantation which has emerged as an effective therapy and potential cure for type 1 diabetes mellitus, requires inhibition of trypsin activity by ulinastatin or pefabloc, optimization of islet preservation using the two-layer method, TLM, overview |
708047 |
3.4.21.4 | more |
a fibronectin type III-like peptide from aqueous extract of human placenta, used as a licensed drug for wound healing, tightly complexes the enzyme and regulates its activity, near-irreversible binding, modeling, overview |
717901 |
3.4.21.4 | more |
analysis of trypsin immunogenicity in male CBA mice compared to other serine proteases, overview |
710556 |
3.4.21.4 | more |
completely conserved major structural features common to trypsin such as the catalytic triad, formed by His57, Asp102, and Ser195, the obligatory Asp189 and twelve Cys residues, but with deletion of Tyr151 and substitution of Pro152 for Gly in the autolysis loop |
717554 |
3.4.21.4 | more |
detailed geometry of the active site and the protonation state of catalytic residues, quantum chemical interpretation, overview |
717850 |
3.4.21.4 | more |
enhanced serine proteinase activity may be playing a role in mitigating physiological costs associated with the maintenance of insecticide resistance mechanisms in some maize weevil strains |
708221 |
3.4.21.4 | more |
the enzyme shows completely conserved structural features for catalytic function of trypsins, but possesses the four Met residues, Met135, Met145, Met175, and Met242, in their molecules and the deletion of Tyr151 and substitution of Pro152 for Gly in their autolysis loops |
717556 |
3.4.21.4 | more |
thrombin and trypsin directly activate vagal C-fibres in C57BL6 mouse lung via protease-activated receptor-1, i.e. PAR1, not via PAR3, PAR2, and PAR4, overview |
718033 |
3.4.21.4 | more |
trypsin 1 is the major blood meal induced trypsin activity in the sand fly midgut |
710193 |