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Literature summary for 3.4.21.4 extracted from

  • Noguchi, H.; Ueda, M.; Hayashi, S.; Kobayashi, N.; Okitsu, T.; Iwanaga, Y.; Nagata, H.; Liu, X.; Kamiya, H.; Levy, M.F.; Matsumoto, S.
    Comparison of trypsin inhibitors in preservation solution for islet isolation (2009), Cell Transplant., 18, 541-547.
    View publication on PubMed
Search for more literature for 3.4.21.4

Inhibitors

Inhibitors Comment Organism Structure
pefabloc
-
 Sus scrofa
ulinastatin
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Sus scrofa
-
pancreatic acinar cell
-
 Sus scrofa
-
pancreatic islet
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-arginine ethyl ester + H2O
-
 Sus scrofa N-benzoyl-L-arginine + ethanol
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Sus scrofa

General Information

General Information Comment Organism
malfunction trypsin from pancreatic acinar cells destroys islets. Thus pancreatic slet transplantation which has emerged as an effective therapy and potential cure for type 1 diabetes mellitus, requires inhibition of trypsin activity by ulinastatin or pefabloc, optimization of islet preservation using the two-layer method, TLM, overview Sus scrofa