EC Number   |
General Information |
Reference |
|---|
  2.4.3.4 | malfunction |
downregulation of isoforms ST3GAL3 and ST3GAL4 results in a significant decrease in cell migration and invasion as well as E-selectin-dependent adhesion of pancreatic cancer cells. Downregulation of isoforms ST3GAL4 and ST3GAL3 in BxPC-3 and Capan-1 cells reduces sLex expression |
764905 |
| 2.4.3.4 | metabolism |
the enzyme is involved in biosynthesis of O-linked oligosaccharide chains of glycoproteins |
745248 |
| 2.4.3.4 | metabolism |
the enzyme specifically modifies glycoproteins and glycolipids which contain the sequence beta-D-Gal-(1->3)-beta-D-GalNAc to form the sequence alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc |
745249 |
| 2.4.3.4 | physiological function |
ST3Gal III overexpression inhibits Taxol-triggered caspase-8 activation. ST3Gal III upregulation produces cellular resistance to taxol and hence reduces the efficacy of taxol therapy |
705677 |
| 2.4.3.4 | physiological function |
the enzyme modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. Isoform ST3Gal III increases de novo expression of SLex by enzymatic competition, enhances pancreatic adenocarcinoma cells adhesion to rh-E-selectin, and increases tumour cell adhesion to HSE cells |
723519 |
| 2.4.3.4 | physiological function |
the enzyme regulates ovarian cancer cell migration and peritoneal dissemination via epidermal growth factor receptor signaling |
759883 |
