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Literature summary for 2.4.3.4 extracted from

  • Huang, S.; Day, T.W.; Choi, M.R.; Safa, A.R.
    Human beta-galactoside alpha-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity (2009), Mol. Cell. Biochem., 331, 81-88.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
drug development ST3Gal III can serve as a therapeutic target of taxol therapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
full-length ST3Gal III DNA fragment subcloned into the pEF6/V5-His TOPO expression vector. SKOV-3 cells transfected with ST3Gal III-EF6 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SKOV-3 cell expresses little ST3Gal III protein Homo sapiens
-

Synonyms

Synonyms Comment Organism
beta-galactoside a-2,3-sialyltransferase
-
 Homo sapiens
ST3Gal III
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens taxol treatment upregulates ST3Gal III expression and forces expression of ST3Gal III attenuated taxol induced apoptosis. Taxol induces the expression of ST3Gal III by a post-transcriptional mechanism in SKOV-3 ovarian cancer cells up

General Information

General Information Comment Organism
physiological function ST3Gal III overexpression inhibits Taxol-triggered caspase-8 activation. ST3Gal III upregulation produces cellular resistance to taxol and hence reduces the efficacy of taxol therapy Homo sapiens