EC Number   |
Expression |
Reference |
|---|
    3.1.1.4 | down |
activation of PLA2 is inhibited by dsRNAs specific to different Toll and Imd genes |
708283 |
| 3.1.1.4 | down |
following oral infection with Trypanosoma rangeli, significant attenuation of PLA2 activities in hemocytes (cPLA2, sPLA2 and iPLA2) in cell-free hemolymph. Trypanosoma rangeli infection inhibits total PLA2 activity in lysates from hemocytes by 39% |
693495 |
| 3.1.1.4 | down |
IL-1beta-mediated induction of cPLA2 expression is abolished by either actinomycin D or cycloheximide in a concentration-dependent manner. SB202190 or SP600125 inhibit cPLA2 protein and mRNA expression induced by IL-1beta. Transfection with JNK2 siRNA or p300 siRNA blocks cPLA2 expression induced by IL-1beta. AACOCF3, U0126, SB202190, SP600125, or helenalin significantly inhibit IL-1beta-stimulated prostaglandin E2 synthesis linked to cPLA2 activity |
709230 |
| 3.1.1.4 | down |
nPLA treatment shows a downregulation of endogenous iPLA2 |
707894 |
| 3.1.1.4 | down |
siRNA1 reduces the expression of cPLA2alpha |
708995 |
| 3.1.1.4 | down |
transfection with iPLA2 siRNA results in ca. 50% reduction in mRNA levels of iPLA2 |
709365 |
| 3.1.1.4 | down |
unstimulated and low density lipoprotein-treated THP-1 cells fail to produce detectable levels of lp-PLA2. Inhibition of either phosphatidylinositol 3-kinase (by LY294002 and wortmannin) or p38 mitogen-activating protein kinase (by SB203580 and SB202190) completely blocks oxidized low density lipoprotein-induced lp-PLA2 expression. Neither platelet activating factor and lyso-platelet activating factor nor 1-palmitoyl-sn-glycerol-3-phosphocholine and high density lipoprotein can induce lp-PLA2 expression |
708019 |
| 3.1.1.4 | down |
Xenorhabdus nematophila induces an immunosuppression of target insects by inhibiting phospholipase A2 activity |
715892 |
| 3.1.1.4 | more |
lipopolysaccharide has no effect on iPLA2 mRNA and does not induce expression of cPLA2-zeta. Lipopolysaccharide does not induce or enhance the release of any sPLA2s. Lipopolysaccharide neither enhances the sPLA2s GIID, GIIE, GIIF, GX and GXIIA constitutively expressed by macrophages nor induces the expression of GIB and GIII, which are undetectable in resting cells |
707554 |
| 3.1.1.4 | up |
cPLA2 protein levels are increased ca. 2fold in muscle homogenates 7 days post-denervation. The cPLA2 protein levels are also elevated in Sod1-/- and G93A mice |
709076 |
