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Literature summary for 3.1.1.4 extracted from
- Activation of immune-associated phospholipase A2 is functionally linked to Toll/Imd signal pathways in the red flour beetle, Tribolium castaneum (2010), Dev. Comp. Immunol., 34, 530-537.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Toll and Imd immune signals induced by bacterial challenge with both Gram-positive (Bacillus subtilis) and negative (Escherichia coli) bacteria to the larvae are linked to the activation of PLA2 | Tribolium castaneum |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | hemocytes from larvae treated with dsRNAs of the Toll and Imd genes do not show translocation of their PLA2s near to cell membrane, at which the PLA2s appear to be evenly spread in the cytoplasm | Tribolium castaneum | 5737 | - |
| membrane | upon bacterial challenge, hemocytes from control larvae show intracellular translocation of their PLA2s near to cell membrane | Tribolium castaneum | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Tribolium castaneum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hemocyte | - |
Tribolium castaneum | - |
| larva | - |
Tribolium castaneum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphocholine + H2O | - |
Tribolium castaneum | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| immune-associated phospholipase A2 | - |
Tribolium castaneum |
| PLA2 | - |
Tribolium castaneum |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Tribolium castaneum | activation of PLA2 is inhibited by dsRNAs specific to different Toll and Imd genes | down |
| Tribolium castaneum | recognition of bacterial challenge initiates Toll and Imd pathways, which subsequently induces the expression of immune-associated PLA2s as well as gene expression of various AMPs | up |
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