Information on EC 3.1.1.4 - phospholipase A2

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.1.4
-
RECOMMENDED NAME
GeneOntology No.
phospholipase A2
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
alpha-Linolenic acid metabolism
-
-
Arachidonic acid metabolism
-
-
aspirin triggered resolvin D biosynthesis
-
-
aspirin triggered resolvin E biosynthesis
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Biosynthesis of secondary metabolites
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Ether lipid metabolism
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Glycerophospholipid metabolism
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Linoleic acid metabolism
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lipid metabolism
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Metabolic pathways
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phosphatidylcholine acyl editing
-
-
phospholipases
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-
phospholipid remodeling (phosphatidate, yeast)
-
-
phospholipid remodeling (phosphatidylcholine, yeast)
-
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phospholipid remodeling (phosphatidylethanolamine, yeast)
-
-
plasmalogen degradation
-
-
resolvin D biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
death adder
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-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
var. K1, bifunctional enzyme bwith both phospholipase A2 and esterase activity
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-
Manually annotated by BRENDA team
sea anemone
-
-
Manually annotated by BRENDA team
strain 216, gene meg A
TrEMBL
Manually annotated by BRENDA team
strain 216, gene meg A
TrEMBL
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
mycotoxin II
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
isoenzyme MjTX-II
-
-
Manually annotated by BRENDA team
Bothrops spp.
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
; calcium-independent phospholipase A2 isoform, IPLA-1
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-
Manually annotated by BRENDA team
clinical strains isolated from children with gastroenteritis
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Crotalus sp.
-
-
-
Manually annotated by BRENDA team
isozymes DsM-bI and DsM-S1
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-
Manually annotated by BRENDA team
leaf-nosed viper
-
-
Manually annotated by BRENDA team
K-12
-
-
Manually annotated by BRENDA team
var. Zhao
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Sea snake
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Sea snake
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
turkey
-
-
Manually annotated by BRENDA team
Indian red scorpion
UniProt
Manually annotated by BRENDA team
small-eyed snake
-
-
Manually annotated by BRENDA team
Micrurus dumerilii carinicauda
-
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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Swissprot
Manually annotated by BRENDA team
king cobra
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
scorpion
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
bacteria
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Manually annotated by BRENDA team
subsp. piscicida
UniProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
Papuan black snake
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-
Manually annotated by BRENDA team
strain PAK-VL1
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain A3(2)
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-
Manually annotated by BRENDA team
strain A3(2)
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-
Manually annotated by BRENDA team
strain A-2688
UniProt
Manually annotated by BRENDA team
synthetic construct
-
-
-
Manually annotated by BRENDA team
three isoenzymes
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-
Manually annotated by BRENDA team
six isoenzymes
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme harbors a consensus motif common to members of the GVIA-iPLA2 subfamily, the group VIA phospholipase A2 (GVIA-iPLA2) subfamily of enzymes functions independently of calcium within the cytoplasm of cells. The Caenorhabditis elegans genome encodes multiple putative GVIAiPLA2 isoforms
malfunction
metabolism
physiological function
additional information
-
isozyme IPLA-1 harbor numerous ankyrin repeats
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+/-)-3-O-(4-cyanomethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
(+/-)-3-O-(4-hydroxymethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
(2'R,2S)-2,3-dihydroxypropyl 2'-octadecanoyloxy-5'-hexadecyloxy-5'-oxopentan-1'-yl phosphate + H2O
?
show the reaction diagram
(2S,2'S,3R)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
(2S,2'S,3S)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
(3E)-3-[(3aS,7aS)-3-methyl-2-oxo-6-(propan-2-ylidene)hexahydro-1-benzofuran-7(4H)-ylidene]propanoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,5aS,8bR)-3,5a,5b-trimethyl-3a,4,5,5a,5b,8b-hexahydro-2H-cyclopenta[2,3]cyclopropa[1,2-g]benzofuran-2,6(3H)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,5aS,9bR)-3,5a,9-trimethyl-3a,4,5,5a-tetrahydronaphtho[1,2-b]furan-2,8(3H,9bH)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,8S,9bS)-6,8-dihydroxy-3,6,9-trimethyl-3,3a,4,5,6,6a,7,8-octahydroazuleno[4,5-b]furan-2(9bH)-one + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,8S,9bS)-8-hydroxy-3,6,9-trimethyl-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,9bS)-3,6,9-trimethyl-2,8-dioxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,9bS)-6-hydroxy-3,6,9-trimethyl-3a,4,5,6,6a,7-hexahydroazuleno[4,5-b]furan-2,8(3H,9bH)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3S)-5a-(1-bromo-1-methylethyl)-3-methyl-3,3a,5,5a,8,9b-hexahydro-4H-furo[2,3-f]chromene-2,7-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(R)-1,2-dipalmitoyl-glycero-3-phosphocholine + H2O
?
show the reaction diagram
(R)-1,2-dipalmitoyl-glycero-3-phosphoglycerol + H2O
?
show the reaction diagram
(R)-1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
enzyme adsorbs to monolayers of L-alpha-1,2-dipalmitoyl-sn-glycero-3-phosphocholine, leading to hydrolysis of the monlayer
-
-
?
(R)-1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phoshocholine + H2O
?
show the reaction diagram
1,2-bis(heptanoylthio)-glycerophosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-bis-(10-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 10-pyrenedecanoate
show the reaction diagram
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid
show the reaction diagram
-
fluorescent substrate
-
?
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
1,2-di-O-hexadecyl-sn-glycerol-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoate
show the reaction diagram
-
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphate + H2O
1-acyl-sn-glycero-3-phosphate + a carboxylate
show the reaction diagram
-
substrate from soybean
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-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
1-acyl-sn-glycero-3-phosphatide + fatty acid
show the reaction diagram
1,2-diacyl-sn-glycero-3-phosphatide + H2O
?
show the reaction diagram
1,2-diacyl-sn-glycero-3-phospho-(1-D-myo-inositol) + H2O
1-acyl-sn-glycero-3-phospho-(1-D-myo-inositol) + a carboxylate
show the reaction diagram
-
substrate from soybean
-
-
?
1,2-diacyl-sn-glycero-3-phosphocholine + H2O
1-acyl-sn-glycero-3-phosphocholine + a carboxylate
show the reaction diagram
-
substrate from soybean
-
-
?
1,2-diacyl-sn-glycero-3-phosphorylcholine + H2O
1-acyl-sn-glycero-3-phosphorylcholine + fatty acid
show the reaction diagram
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
1,2-diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O
1-heptanoyl-sn-glycero-3-phosphocholine + heptanoate
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O
1-heptanoyl-sn-glycero-3-sulfate + heptanoate
show the reaction diagram
1,2-dihexadecanoyl-rac-glycero-3-phosphorac-(1-glycerol) + H2O
?
show the reaction diagram
-
pyrene-modified or unmodified phospholipid substrate
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laurate
show the reaction diagram
-
-
-
-
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laureate
show the reaction diagram
1,2-dilinoleoyl-phosphatidylcholine + H2O
1-linoleoyl-sn-glycero-3-phosphocholine + linoleic acid
show the reaction diagram
-
-
-
-
?
1,2-dilinoleoyl-sn-glycero-3-phosphocholine + H2O
1-linoleoyl-sn-glycero-3-phosphocholine + linoleoate
show the reaction diagram
-
-
-
-
?
1,2-dimyristol-sn-glycero-phosphomethanol lithium salt + H2O
myristic acid + 1-myristoyl-sn-glycerophosphomethanol
show the reaction diagram
1,2-dimyristoyl-sn-glycero-3 phosphocholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
-
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
1-myristoyl-sn-glycero-3-phosphocholine + myristate
show the reaction diagram
-
-
-
-
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
1-myristoyl-sn-glycero-3-phosphocholine + myristic acid
show the reaction diagram
-
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
1,2-dimyristoyl-sn-phosphatidylinositol + H2O
1-myristoyl-sn-phosphatidylinositol + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylserine + H2O
1-myristoyl-sn-phosphatidylserine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O
1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate
show the reaction diagram
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O
1-octanoyl-sn-glycero-3-phosphoglycol + octanoate
show the reaction diagram
1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
?
show the reaction diagram
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
preferred substrate
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoylglycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
1-oleoyl-sn-glycero-3-phosphoethanolamine + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphorac-(1-glycerol) + H2O
1-oleoyl-sn-glycero-3-phosphorac-(1-glycerol) + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoserine + H2O
1-oleoyl-sn-glycero-3-phosphoserine + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + oleic acid
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-phosphatidylcholine + H2O
1-oleoyl-sn-phosphatidylcholine + oleate
show the reaction diagram
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
1,2-dipalmitoyl-L-3-phosphatidylcholine + H2O
1-palmitoylphosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + palmitate
show the reaction diagram
substrate from egg yolk
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-phosphatidylcholine + palmitate
show the reaction diagram
in sn-2 position, linoleate is preferred over palmitate
-
-
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphoethanolamine + palmitate
show the reaction diagram
substrate from egg yolk
-
-
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphatidylethanolamine + palmitic acid
show the reaction diagram
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
show the reaction diagram
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoylglycerophosphocholine + palmitic acid
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-phosphatidylinositol 4,5-bisphosphate + H2O
1-palmitoyl-sn-glycero-3-phosphoethanolamine-N-phosphatidylinositol 4,5-bisphosphate + palmitic acid
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-glycero-3-phosphoglycerol + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + palmitate
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitic acid
show the reaction diagram
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-phosphatidylserine + H2O
1-palmitoyl-sn-phosphatidylserine + palmitic acid
show the reaction diagram
1,2-dithio-deheptanoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
1,2-dithio-heptanoylphosphatidylcholine + H2O
?
show the reaction diagram
-
detection of reaction product with 5,5'-dithio-bis-(2-nitrobenzoic acid)
-
-
?
1-acryl-2(N-4-nitrobenzo-2-oxo-1,3-diazole)aminocapryl-phosphatidylcholine + H2O
1-acrylglycerophosphocholine + (N-4 nitrobenzo-2-oxo,1,3-diazole)-aminocaproic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
1-acyl-2-arachidonoyl-sn-glycerol phosphoethanolamine + H2O
1-acyl-sn-glycerol phosphoethanolamine + arachidonate
show the reaction diagram
radiolabeled substrate
-
-
?
1-acyl-2-arachidonoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glyerophosphoethanolamine + H2O
1-acyl-sn-glyerophosphoethanolamine + arachidonic acid
show the reaction diagram
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
1-acyl-3-phosphoethanolamine + linolic acid
show the reaction diagram
1-acyl-2-linoleoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + linolic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + linoleic acid
show the reaction diagram
-
-
-
?
1-acyl-2-oleoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-acyl-2-palmitoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + palmitic acid
show the reaction diagram
-
-
-
?
1-decanoyl-2-(4-nitrophenylglutaryl)glycerol 3-phosphate + H2O
?
show the reaction diagram
-
HSD-PLA2
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphatidic acid + H2O
?
show the reaction diagram
-
group V sPLA2
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoethanolamine + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + 1-pyrenedecanoate
show the reaction diagram
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoserine + H2O
1-hexadecanoyl-glycero-3-phosphoserine + 1-pyrenedecanoate
show the reaction diagram
-
group V sPLA2
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
fluorometric determination
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O
?
show the reaction diagram
-
micellar substrate
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphogylcerol + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphatidyl choline + H2O
?
show the reaction diagram
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-(10-(1-pyrene)decanoyl)-sn-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-sn-glycero-3-phosphoglycerol + 10-(1-pyrene)decanoic acid
show the reaction diagram
1-hexadecanoyl-2-(10-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 10-pyrenedecanoate
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-9(cis)-octadecanoyl-rac-glycero-phosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + acetate
show the reaction diagram
-
i.e. PAF or platelet activating factor
-
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
show the reaction diagram
i.e. platelet-activating factor
-
-
?
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O
1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
-
-
?
1-O-hexadecyl-2-[(cis)-9-octadecenoyl]-rac-glycero-3-phosphocholine + H2O
1-O-hexadecyl-rac-glycero-3-phosphocholine + cis-9-octadecenoate
show the reaction diagram
-
-
-
?
1-oleoyl-2-isolauroyl phosphatidylethanolamine + H2O
1-oleoyl phosphatidylethanolamine + isolauric acid
show the reaction diagram
-
-
-
?
1-oleoyl-2-palmitoyl-phosphatidylcholine + H2O
1-oleoyl-phosphatidylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
1-oleoyl-2-stearoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + stearate
show the reaction diagram
-
-
-
-
?
1-oleoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-phosphate + H2O
10-pyrenyldecanoic acid + 1-palmitoyl-sn-glycero-3-phosphate
show the reaction diagram
1-palmitoyl-2-(12-(3-(4-hydroxyphenyl)propionyl)amino dodecanoyl)phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphorylcholine + 12-(3-(4-hydroxyphenyl)propionyl)amino dodecanoate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-glycero-3-phosphoglycerol + arachidonate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
isoform cPLA2-beta and cPLA2-gamma hydrolyse this substrate at a lower rate than isoform cPLA2-alpha
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
show the reaction diagram
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
GIVA cPLA2 substrate and GIVA iPLA2
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
1-palmitoyl-2-arachidonoylphosphatidylethanolamine
1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid
show the reaction diagram
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
1-palmitoyl-2-arachidonylphosphocholine + H2O
1-palmitoyl-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
-
?
1-palmitoyl-2-arachidonylphosphoethanolamine + H2O
1-palmitoyl-glycerophosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidic acid + H2O
1-palmitoyl-sn-glycero-3-phosphate + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + linoleate
show the reaction diagram
in sn-2 position, linoleate is preferred over palmitate
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphoethanolamine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylethanolamine + H2O
1-palmitoyl-sn-glycerophosphoethanolamine + linoleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylinositol + H2O
1-palmitoyl-3-phosphoinositol + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylserine + H2O
1-palmitoyl-sn-glycero-3-phosphoserine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleoic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linolic acid
show the reaction diagram
1-palmitoyl-2-linoleoyl-sn-glycerophosphorylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
1-palmitoyl-2-linoleoylphosphocholine + H2O
1-palmitoyl-glycerophosphocholine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
1-palmitoylphosphocholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
?
show the reaction diagram
1-palmitoyl-2-oleoyl-phosphatidylethanolamine + H2O
?
show the reaction diagram
1-palmitoyl-2-oleoyl-phosphatidylglycerol + H2O
?
show the reaction diagram
1-palmitoyl-2-oleoyl-phosphatidylinositol + H2O
?
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + H2O
?
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-(1-glycerol) + H2O
1-palmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-glycero-3-phosphoglycerol + oleate
show the reaction diagram
-
preferred substrate
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleic acid
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + oleate
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
oleic acid + 1-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
from egg yolk
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
show the reaction diagram
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphoglycerol + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
show the reaction diagram
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
?
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
1-palmitoyl-2-palmitoyl-sn-glycerophosphocholine + H2O
1-palmitoyl-sn-glycerophosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-palmitoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
1-palmitoyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonate
show the reaction diagram
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-stearoyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O
1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid
show the reaction diagram
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
1-stearoyl-2-arachidonyl-phosphatidylinositol 4,5-bisphosphate + H2O
1-stearoyl-sn-glycero-3-phosphoinositol 4,5-bisphosphate + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonylphosphocholine + H2O
1-stearoyl-glycerophosphocholine + stearic acid
show the reaction diagram
-
-
?
1-stearoyl-2-linolenoyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
preferred substrate
-
?
1-stearoyl-2-linoleoyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + linoic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-oleoyl-3-sn-glycerophosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-oleoyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + oleic acid
show the reaction diagram
-
-
hydrolysis occurs only in sn2 position of phospholipids
-
?
1-stearoyl-2-palmitoyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + palmitic acid
show the reaction diagram
-
-
-
?
4-nitro-3-(octanoyloxy) benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
-
-
-
-
?
4-nitro-3-(octanoyloxy) benzoic acid + H2O
4-nitrobenzoate + octanoate
show the reaction diagram
-
-
-
-
?
4-nitro-3-(octanoyloxy) benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
4-nitro-3-(octanoyloxy)benzoic acid + H2O
?
show the reaction diagram
4-nitro-3-octanoyloxy-benzoic acid + H2O
?
show the reaction diagram
4-nitro-3-octanoyloxybenzoic acid + H2O
?
show the reaction diagram
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
show the reaction diagram
-
-
-
?
6-dodecanoyl-2-dimethylaminonaphthalene + H2O
?
show the reaction diagram
-
-
-
-
?
acrylodan-labeled fatty acid-binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
arachidonyl thio-PC + H2O
arachidonic acid + (7R)-4-hydroxy-N,N,N-trimethyl-7-sulfanyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide
show the reaction diagram
cardiolipin + H2O
?
show the reaction diagram
-
-
-
-
-
choline plasmalogen + H2O
lysoplasmalogen + fatty acid
show the reaction diagram
-
-
-
?
D,L-alpha-dipalmitoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
DBPA + H2O
?
show the reaction diagram
DBPC + H2O
?
show the reaction diagram
DBPE + H2O
?
show the reaction diagram
DBPG + H2O
?
show the reaction diagram
diarachidonylphosphatidylcholine + H2O
arachidonylphosphatidylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
-
-
-
?
dihexanoyl-dithio-phosphatidylcholine + H2O
?
show the reaction diagram
proPLA2, monomeric substrate
-
-
?
dioctanoyl phosphatidylcholine + H2O
octanoyl phosphatidylcholine + octanoate
show the reaction diagram
-
-
-
?
dioleoyl phosphatidylglycerol + H2O
?
show the reaction diagram
dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + palmitic acid
show the reaction diagram
-
GIVA iPLA2 and GV sPLA2
-
-
?
diphosphatidylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
egg yolk + H2O
?
show the reaction diagram
egg yolk phospholipid + H2O
?
show the reaction diagram
ethanolamine plasmalogen + H2O
lysoplasmalogen + fatty acid
show the reaction diagram
-
-
-
?
glycerophospholipid + H2O
arachidonic acid + ?
show the reaction diagram
-
-
-
-
?
hen egg phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
L-1-acyl-2-arachidonyl-sn-glycerol-3-phosphatidylethanolamine + H2O
?
show the reaction diagram
-
-
-
?
L-alpha-dipalmitoyl phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
L-alpha-dipalmitoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
L-alpha-phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
L-dipalmitoyl phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + palmitate
show the reaction diagram
L-dipalmitoyl-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
l-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
NBD-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized high density lipoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized low density lipoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized palmitoyl arachidonyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized phosphatidylcholine + H2O
lysophosphatidylcholine + fatty acid
show the reaction diagram
oxidized phosphatidylcholines + H2O
1-acylglycerophosphocholine + oxidized fatty acids
show the reaction diagram
p-nitrophenyl laurate + H2O
p-nitrophenol + laurate
show the reaction diagram
-
23.7% of the activity with p-nitrophenyl propionate
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoic acid
show the reaction diagram
-
79.5% of the activity with p-nitrophenyl propionate
-
-
?
p-nitrophenyl propionate + H2O
p-nitrophenol + propionate
show the reaction diagram
-
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
palmitoyl-sn-glycerophosphocholine + oleate
show the reaction diagram
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
palmitoyl-sn-glycerophosphoethanolamine + oleate
show the reaction diagram
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
palmitoyl-sn-glycerophosphoglycerol + oleate
show the reaction diagram
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
phosphatidycholine + H2O
lysophosphatidylcholine + a fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + arachidonic acid
arachidonoyl phosphatidylcholine
show the reaction diagram
-
-
-
r
phosphatidylcholine + H2
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
phosphatidylcholine + H2O
?
show the reaction diagram
-
the enzyme shows preferential hydrolysis of phosphatidylcholine
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
phosphatidylcholine + linoleic acid
lineoyl phosphatidylcholine
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + arachidonic acid
arachidonoyl phosphatidylethanolamine
show the reaction diagram
-
-
-
r
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
phosphatidylethanolamine + linoleic acid
lineoyl phosphatidylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
phosphatidylinositol + arachidonic acid
arachidonoyl phosphatidylinositol + fatty acid
show the reaction diagram
phosphatidylinositol + linoleic acid
lineoyl phosphatidylinositol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + arachidonic acid
arachidonoyl phosphatidylserine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + H2O
1-acylglycerophosphoserine + fatty acid
show the reaction diagram
phosphatidylserine + linoleic acid
lineoyl phosphatidylserine + fatty acid
show the reaction diagram
-
-
-
?
phospholipid + H2O
lysophospholipid + fatty acid
show the reaction diagram
phospholipids + H2O
?
show the reaction diagram
pigment epithelium-derived 6 + H2O
?
show the reaction diagram
-
i.e. PED6, a synthetic substrate
-
-
?
plasmalogen + H2O
?
show the reaction diagram
-
-
-
-
?
platelet activating factor + H2O
?
show the reaction diagram
platelet activating factor + H2O
lyso-platelet activating factor
show the reaction diagram
-
-
-
-
?
rac-1,2-dihexanoyldithiopropyl-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
sn-2-arachidonyl phosphatidylcholine + H2O
phosphatidylcholine + arachidonate
show the reaction diagram
-
-
-
-
?
sn-3-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
soya lecithin + H2O
?
show the reaction diagram
-
-
-
?
additional information
?
-