Information on EC 3.1.1.4 - phospholipase A2

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
3.1.1.4
-
RECOMMENDED NAME
GeneOntology No.
phospholipase A2
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
mechanism
-
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
mechanism
-
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
the active site His48 is conserved in all venom PLA2s
-
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
Ca2+-independent catalytic mechanism, overview
P45881
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
alpha-Linolenic acid metabolism
-
Arachidonic acid metabolism
-
Ether lipid metabolism
-
Glycerophospholipid metabolism
-
Linoleic acid metabolism
-
Metabolic pathways
-
phosphatidylcholine acyl editing
-
phospholipases
-
phospholipid remodeling (phosphatidate, yeast)
-
phospholipid remodeling (phosphatidylcholine, yeast)
-
phospholipid remodeling (phosphatidylethanolamine, yeast)
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1-CysPrx
-
a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities, also known as peroxiredoxin VI, non-selenium glutathione peroxidase, LTW4, antioxidant protein 2 (AOP2), Clara cell protein 26 (CC26) and p67phox binding protein
1-cysteine peroxiredoxin
-
a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities
14 kDa phospholipase A2
-
-
-
-
A2-IIA
P00630
-
A2-IIA
P14555
-
Acanmyotoxin-1
-
-
acidic Asp49 phospholipase A2
B5U6Z2
-
acidic Ca2+-independent phospholipase A2
-
-
acidic phospholipase A2
-
-
acidic phospholipase A2
-
-
adiponutrin
-
-
Agkistrotoxin
-
-
-
-
AgkTx-II
-
-
alpha-type phospholipase A2
-
-
amdI1
-
-
-
-
Ammodytin I2
-
-
-
-
ammodytoxin A
-
-
APLA
-
-
-
-
APP-D-49
-
-
-
-
Arg49 phospholipase A2
-
-
Arg49 phospholipase A2 homologue
P84776
-
Asp49 basic myotoxic PLA2
-
-
Asp49 PLA2
Q8QG87
-
Asp49-PLA2
P45881
-
ASPLA1
-
-
-
-
ASPLA10
-
-
-
-
ASPLA11
-
-
-
-
ASPLA12
-
-
-
-
ASPLA13
-
-
-
-
ASPLA14
-
-
-
-
ASPLA15
-
-
-
-
ASPLA16
-
-
-
-
ASPLA17
-
-
-
-
ASPLA2
-
-
-
-
ASPLA3
-
-
-
-
ASPLA4
-
-
-
-
ASPLA5
-
-
-
-
ASPLA6
-
-
-
-
ASPLA7
-
-
-
-
ASPLA8
-
-
-
-
ASPLA9
-
-
-
-
Ats-PLA2-alpha
Q8S8N6
-
AtsPLA2-alpha
-
-
AtsPLA2-gamma
Q9M0D7
-
ATX
-
-
-
-
basic Asp49 PLA2
-
-
Basic protein I/II
-
-
-
-
BaTX
P24605
-
BinTx-I
Q8QG87
-
BinTx-II
Q8QG87
-
BJ-PLA2
-
-
-
-
BJUPLA2
-
-
-
-
Bothropstoxin-I
-
-
BPI/BPII
-
-
-
-
BthTX-II
P45881
-
Ca+2-independent PLA2
-
-
Ca2+ independent PLA2
-
group VIA PLA2
Ca2+-independent phospholipase A2
-
-
Ca2+-independent PLA2
-
-
CaI-PLA2
-
-
-
-
calcium-d-independent cytosolic PLA2
-
-
calcium-dependent cytosolic PLA2
-
-
calcium-independent phospholipase A2
-
-
Caudoxin
-
-
-
-
Cdt PLA2
P24027
subunit B
class XIB phospholipase A2
Q9XG81
-
cPLA2
P47712
-
cPLA2
P47713
-
cPLA2 alpha
-
-
cPLA2-alpha
-
-
cPLA2-gamma
-
-
cPLA2-zeta2
-
-
cPLA2alpha
-
isoform
cPLA2alpha
-
-
cPLA2beta
-
isoform
cPLA2delta
-
isoform
cPLA2epsilon
-
isoform
cPLA2zeta
-
isoform
cPm09
-
-
-
-
crotapotin
P24027
subunit A
crotoxin
P20474
-
CTX
P20474
-
cytoplasmic phospholipase A2
-
-
cytosolic calcium-dependent PLA2
-
GIVA PLA2
cytosolic gIVaPLA2
-
-
cytosolic group IVa phospholipase A2
-
-
cytosolic phospholipase A2
-
-
cytosolic phospholipase A2
-
-
cytosolic phospholipase A2
P47713
-
cytosolic phospholipase A2 alpha
-
-
cytosolic phospholipase A2-alpha
-
-
cytosolic phospholipase A2alpha
-
-
cytosolic phospholipase A2alpha
-
-
cytosolic phospholipase A2alpha
-
-
cytosolic PLA2
-
-
cytosolic PLA2
-
-
cytotoxin ExoU
Pseudomonas aeruginosa PA103, Pseudomonas aeruginosa PAK-VL1
-
-
-
DrK-aII
-
-
DrK-bII
-
-
Enhancing factor
-
-
-
-
exoenzyme U
-
-
exoenzyme U
Pseudomonas aeruginosa PAK-VL1
-
-
-
ExoU-specific PLA2
-
-
ExoU-specific PLA2
Pseudomonas aeruginosa PAK-VL1
-
-
-
GIA cobra venom PLA2
-
-
GIIA
-
-
GIIA PLA2
-
-
GIIA sPLA2
P14555
-
GIIC sPLA2
-
-
-
-
GIID
-
-
GIID sPLA2
-
-
-
-
GIIE
-
-
GIIE sPLA2
-
-
-
-
GIIF
-
-
GIIF sPLA2
-
-
-
-
GIII sPLA2
-
-
-
-
GIIIsPLA2
C6YBD6
-
GIVA
-
-
GIVA phospholipase A2
-
-
GIVA PLA2
-
cytosolic calcium-dependent PLA2
GIVA PLA2
-
-
GIVA PLA2
-
-
GIVF
-
-
Gln49-PLA2
-
-
group IA PLA2
-
-
Group IB phospholipase A2
-
-
-
-
Group IB phospholipase A2
-
-
group IB PLA2
-
-
group II snake venom phospholipase A2
B5U6Z2
-
Group IIA phospholipase A2
-
-
-
-
Group IIA phospholipase A2
-
-
group IIA PLA2
-
-
group IIA secretory phospholipase A2
-
-
group IIA secretory PLA2
-
-
group III Glu62-phospholipase A2
Q6T178
-
group III PLA2
-
-
group III sPLA2
C6YBD6
-
group IV cPLA2
-
-
group IVA cPLA2
-
-
group IVA cytosolic phospholipase A2
-
-
group IVA phospholipase A2
-
-
group IVA phospholipase A2
-
-
group IVA phospholipase A2
-
-
group IVA PLA2
-
cytosolic calcium-dependent PLA2
group IVB phospholipase A2
-
-
Group V phospholipase A2
-
-
-
-
group V secreted phospholipase A2
-
-
Group VI phospholipase A2
-
-
-
-
Group VIA Ankyrin-1
-
syn: iPLA2-1, splice variant of iPLA2
Group VIA Ankyrin-2
-
syn: iPLA2-2, splice variant of iPLA2
group VIA calcium-independent phospholipase A
-
-
group VIA cPLA2
-
-
Group VIA PLA2
-
-
Group VIA PLA2
-
-
Group VIA-3
-
syn: iPLA2-2, splice variant of iPLA2
group X secreted phospholipase A2
-
-
GVI PLA2
-
-
-
-
GVIA
-
-
GVIIA PLA2
-
PAF acetyl hydrolase/oxidized lipid LpPLA2
GX sPLA2
-
-
-
-
GX sPLA2
-
-
GXII sPLA2
-
-
-
-
GXIIA
-
-
GXIII sPLA2
-
-
-
-
hGX sPLA2
-
-
hIBPLA2
-
-
hIIAPLA2
-
-
human group IB PLA2
-
-
human group IIA phospholipase A2
-
-
IB PLA2
-
-
immune-associated phospholipase A2
-
-
imperatoxin
-
-
iPLA2
-
-
-
-
iPLA2
-
-
iPLA2-gamma
-
-
jerdoxin
Q8JIY9
-
lecithinase A
-
-
-
-
lipoprotein associated phospholipase A2
-
-
lipoprotein-associated phospholipase A2
-
-
lipoprotein-associated phospholipase A2
-
Lp-PLA2
lipoprotein-associated phospholipase A2
Q13093
-
lipoprotein-associated phospholipase A2
-
-
lipoprotein-associated PLA2
-
-
LM-PLA2-I
-
-
LM-PLA2-II
-
-
Lp-PLA2
-
-
Lp-PLA2
Q13093
-
Lp-PLA2
-
-
Lys49 phospholipase A2 homologue
P24605
-
Lys49-phospholipase A2 homologue
P58399
-
Lys49-PLA2
P58399
-
lysophospholipase
-
-
lysosomal phospholipase A2
-
-
marine snail digestive phospholipase A2
-
-
megacin A-216
A7LGL2
-
megacin A-216
Bacillus megaterium 216
A7LGL2
-
-
MiDCA1
Micrurus dumerilii carinicauda
-
-
milleporin-1
-
-
MP-III 4R
-
-
-
-
Muscarinic inhibitor
-
-
-
-
mycotoxin II
P24605
-
myotoxic Asp49-phospholipase A2
P45881
-
myotoxic phospholipase A2
-
-
Myotoxin
-
-
-
-
myotoxin I
-
-
NAJPLA-2A
-
-
-
-
NAJPLA-2B
-
-
-
-
NAJPLA-2C
-
-
-
-
natratoxin
-
-
neuropathy target esterase
-
-
neutral anticoagulant secretory phospholipase A2
-
-
Nigexine
-
-
-
-
NK-PLA2-I
-
-
NK-PLA2-II
-
-
NN-X-PLA2
-
-
NN-XI-PLA2
-
-
NN-XIa-PLA2
-
-
NND-IV-PLA2
-
-
Non-pancreatic secretory phospholipase A2
-
-
-
-
Notechis 11'2
-
-
-
-
Notexin
-
-
-
-
notexinII-1
-
-
NPLA
-
-
-
-
NPS-PLA2
-
-
-
-
OHV A-PLA2
-
-
-
-
OHV-APLA2
-
-
-
-
PAF acetyl hydrolase/oxidized lipid LpPLA2
-
-
PAF-AH
-
Lp-PLA2
PAF-AH
-
-
pancreatic phospholipase A2
-
-
pancreatic phospholipase A2
-
-
pancreatic-type PLA2
-
-
peroxiredoxin 6
-
-
pgPLA 1a/pgPLA 2a
-
-
-
-
phosphatidase
-
-
-
-
phosphatide 2-acylhydrolase
-
-
-
-
phosphatidolipase
-
-
-
-
Phosphatidylcholine 2-acylhydrolase
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIC
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIID
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIE
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIIF
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GIII
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GX
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GXII
-
-
-
-
Phosphatidylcholine 2-acylhydrolase GXIII
-
-
-
-
phospholipase A
-
-
-
-
phospholipase A2
-
-
phospholipase A2
A7LGL2
-
phospholipase A2
Bacillus megaterium 216
A7LGL2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
P00596
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
-
-
phospholipase A2
P00592
-
phospholipase A2
-
-
phospholipase A2 D49
-
-
Phospholipase A2 inhibitor
-
-
-
-
phospholipase A2 neurotoxin
-
-
phospholipase A2alpha
-
-
phospholipase A2s
-
-
phospholipin
-
-
pkP5
-
-
-
-
PLA2
P00630
-
PLA2
A7LGL2
-
PLA2
Bacillus megaterium 216
A7LGL2
-
-
PLA2
P20474
-
PLA2
Q8QG87
-
PLA2
Crotalus sp.
-
-
PLA2
-
a group IIA isozyme
PLA2
-
-
PLA2
-
-
PLA2
P15445
-
PLA2
-
-
PLA2
-
-
PLA2
O96100
-
PLA2
Pseudomonas aeruginosa PAK-VL1
-
-
-
PLA2
Streptomyces violaceoruber A-2688
Q6UV28
-
-
PLA2 CM2
P00596
-
PLA2 neurotoxin
-
-
PLA2-10
-
-
-
-
PLA2-1B
-
-
PLA2-2A
-
-
PLA2-2C
-
-
PLA2-I
-
-
PLA2-L
-
identical to cPLA2-alpha
PLA2-V
-
-
PLA2-VI
-
-
-
-
PLA2-VII
-
-
-
-
PLA2alpha
-
-
PLA2IID
-
-
-
-
PLA2s
-
-
platelet activating factor acetyl hydrolase
-
-
-
-
platelet activating factor acetyl hydrolase/oxidized lipid LpPLA2
-
GVIIA PLA2
platelet-activating factor acetylhydrolase
-
-
platlet-activating factor acetylhydrolase
-
Lp-PLA2
PrTX-1
P58399
-
PrTX-III
-
-
Pt-PLA1
-
-
-
-
Pt-PLA2
-
-
-
-
RVV acidic PLA2-I
-
-
RVVA-PLA2-I
-
-
SCO1048 protein
-
-
secreted group IID phospholipase A2
-
-
secreted human phospholipase A2
-
-
secreted phospholipase A2
P03135
-
secreted phospholipase A2
-
-
secreted phospholipase A2
P14555
-
secreted phospholipase A2
-
-
secreted phospholipase A2
-
-
secreted phospholipase A2
-
-
secreted phospholipase A2
Q6UV28
-
secreted phospholipase A2
Streptomyces violaceoruber A-2688
Q6UV28
-
-
secreted phospholipase A2
-
-
secreted phospholipaseA2 neurotoxin
-
-
secreted phospholipases A2
-
-
secreted phospholipases A2
-
-
secreted PLA2
-
sPLA2
secreted PLA2
-
-
secretory Ca2+-dependent PLA2
-
-
secretory phospholipase
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
P00630
-
secretory phospholipase A2
C6YBD6
-
secretory phospholipase A2
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
P14555
-
secretory phospholipase A2
Q6T178
-
secretory phospholipase A2
-
-
secretory phospholipase A2
-
-
secretory phospholipase A2
P15445
-
secretory phospholipase A2
-
-
secretory phospholipase A2
C0LTQ2
-
secretory phospholipase A2
-
-
secretory phospholipase A2 group IIA
-
-
secretory phospholipase A2 type IB
P00592
-
secretory phospholipase A2 type IIA
-
-
secretory phospholipase A2-alpha
-
-
secretory PLA2s
-
-
Secretory-type PLA, stroma-associated homolog
-
-
-
-
snake presynoptic phospholipase A2 neurotoxin
-
-
specific phospholipase A2
-
-
sPLA(2)
-
-
sPLA(2)-IID
-
-
-
-
sPLA(2)-IIE
-
-
-
-
sPLA(2)-IIF
-
-
-
-
sPLA2
P00630
-
sPLA2
-
-
sPLA2
P14555
-
sPLA2
-
-
sPLA2
-
-
sPLA2
Q9XG81
-
sPLA2
-
-
sPLA2
P00592
-
sPLA2
C0LTQ2
-
sPLA2 GIB
-
-
sPLA2 GIIA
-
-
sPLA2 IB
P00592
-
sPLA2(IIA)
-
-
sPLA2-IB
-
-
sPLA2-IIA
-
-
sPLA2-IIA
-
sPLA2
sPLA2-IID
-
-
sPLA2-IIE
-
-
sPLA2-V
-
-
sPLA2-X
-
-
sPLA2:
Q6T178
-
sPLA2IB2
-
-
taipoxin
-
-
textilotoxin
-
-
thrombin inhibitor from Naja haje
-
-
TI-Nh
-
-
TMV-K49
-
-
-
-
toxin I
-
-
Toxin VI
-
-
-
-
Toxin VI:5
-
-
-
-
trimorphin
Trimorphodon biscutatus lambda
-
-
TTS-2.2
-
-
type III cytotoxin
-
-
type VIIA PLA2
-
Lp-PLA2
type VIIA PLA2
-
-
zhaoermiatoxin
P84776
-
MjTX-II
-
-
additional information
P00630
the enzyme belongs to the group III PLA2s
additional information
-
the enzyme belongs to the group II PLA2s
additional information
P20474
the enzyme belongs to the group II phospholipases A2
additional information
-
a group IIB isozyme
additional information
-
Cr-IV 1 as a member of the D49 PLA2 family
additional information
-
cf. EC 3.1.1.34
additional information
-
secreted phospholipase A2 isozymes from groups A, B, D, E, F, V, and X
additional information
-
the enzyme is a group X secreted phospholipase A2
additional information
Q13093
cf. EC 3.1.1.47, Lp-PLA2 is a member of the phospholipase A2 superfamily and belongs to the VII phospholipase A2 subgroup
additional information
-
secreted phospholipase A2 isozymes from groups A, B, D, E, F, V, and X
additional information
-
sPLA2 belong to groups IIE, III, V, and X
additional information
P47713
the cytosolic PLA2 belongs to the group IV PLA2s
additional information
-
the enzyme belongs to the group I PLA2s
additional information
P84776
Arg49 phospholipase A2 homologue is a member of the PLA2-homologue family that possesses an arginine residue at position 49, probably arising from a secondary K49R substitution
additional information
P84776
the toxin is a group II phospholipase A2
CAS REGISTRY NUMBER
COMMENTARY
9001-84-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
death adder
-
-
Manually annotated by BRENDA team
var. K1, bifunctional enzyme bwith both phospholipase A2 and esterase activity
-
-
Manually annotated by BRENDA team
sea anemone
-
-
Manually annotated by BRENDA team
precursor
UniProt
Manually annotated by BRENDA team
AtPLA I; AtPLA IIA
-
-
Manually annotated by BRENDA team
strain 216, gene meg A
TrEMBL
Manually annotated by BRENDA team
Bacillus megaterium 216
strain 216, gene meg A
TrEMBL
Manually annotated by BRENDA team
cow
-
-
Manually annotated by BRENDA team
mycotoxin II
SwissProt
Manually annotated by BRENDA team
isoenzyme myotoxin II
-
-
Manually annotated by BRENDA team
precursor
UniProt
Manually annotated by BRENDA team
isozyme BinTx-I; two isozymes BinTx-I and BinTx-II
SwissProt
Manually annotated by BRENDA team
isoenzymes BthTX-I, BthTX-II
-
-
Manually annotated by BRENDA team
isozyme Bj-V
-
-
Manually annotated by BRENDA team
isoenzyme MjTX-II
-
-
Manually annotated by BRENDA team
isoenzymes PrTX-I, PrTX-III
-
-
Manually annotated by BRENDA team
PrTX-1, a noncatalytic, myotoxic Lys49-phospholipase A2 homologue
UniProt
Manually annotated by BRENDA team
Bothrops spp.
-
-
-
Manually annotated by BRENDA team
four isozymes
-
-
Manually annotated by BRENDA team
clinical strains isolated from children with gastroenteritis
-
-
Manually annotated by BRENDA team
South American rattlesnake
-
-
Manually annotated by BRENDA team
Crotalus sp.
-
-
-
Manually annotated by BRENDA team
isozymes DrK-aI, DrK-aII, DrK-bI, and DrK-bII
-
-
Manually annotated by BRENDA team
Russell's viper
Uniprot
Manually annotated by BRENDA team
Russell's viper
-
-
Manually annotated by BRENDA team
Indian Russell's viper
-
-
Manually annotated by BRENDA team
Indian Russell's viper, chain viper
UniProt
Manually annotated by BRENDA team
isozymes DsM-bI and DsM-S1
-
-
Manually annotated by BRENDA team
Indian Saw-Scawled Viper
-
-
Manually annotated by BRENDA team
saw-scaled viper
-
-
Manually annotated by BRENDA team
horse
SwissProt
Manually annotated by BRENDA team
leaf-nosed viper
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
cPLA2; isozyme cPLA2
SwissProt
Manually annotated by BRENDA team
expression in Escherichia coli
-
-
Manually annotated by BRENDA team
isozyme sPLA2IB2; isozymes sPLA2-IIA, sPLA2-V, and sPLA2-X
-
-
Manually annotated by BRENDA team
isozymes hGIIA sPLA2, hGIB sPLA2, hGX sPLA2, and hGV sPLA2
-
-
Manually annotated by BRENDA team
secreted human phospholipase A2, i.e. sPLA2-X
-
-
Manually annotated by BRENDA team
isoforms LmTX-1, LmTX-II
-
-
Manually annotated by BRENDA team
Lapemis hardwickii
Sea snake
-
-
Manually annotated by BRENDA team
Indian red scorpion
UniProt
Manually annotated by BRENDA team
small-eyed snake
-
-
Manually annotated by BRENDA team
Micrurus dumerilii carinicauda
-
-
-
Manually annotated by BRENDA team
female BALB/c mice
-
-
Manually annotated by BRENDA team
gene lpla2
-
-
Manually annotated by BRENDA team
isozymes of sPLA2 groups IIE, III, V, and X
Uniprot
Manually annotated by BRENDA team
male C57BL/6J mice
-
-
Manually annotated by BRENDA team
male DBA/1J mice
-
-
Manually annotated by BRENDA team
Taiwan cobra
-
-
Manually annotated by BRENDA team
Taiwan cobra
Uniprot
Manually annotated by BRENDA team
isoenzymes NK-PLA2-I and NK-PLA2-II
-
-
Manually annotated by BRENDA team
cobra
Uniprot
Manually annotated by BRENDA team
isoforms NN-XI-PLA2, NN-XIa-PLA2
-
-
Manually annotated by BRENDA team
-
Q5CCT8
Swissprot
Manually annotated by BRENDA team
Chrysophrys major, red sea bream
-
-
Manually annotated by BRENDA team
red sea bream
-
-
Manually annotated by BRENDA team
scorpion
-
-
Manually annotated by BRENDA team
isoenzyme II
-
-
Manually annotated by BRENDA team
Papuan black snake
-
-
Manually annotated by BRENDA team
strain PA103
-
-
Manually annotated by BRENDA team
strain PAK-VL1
-
-
Manually annotated by BRENDA team
strain PAO1
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa PAK-VL1
strain PAK-VL1
-
-
Manually annotated by BRENDA team
female Sprague Dawley rats
-
-
Manually annotated by BRENDA team
female Zucker rats
-
-
Manually annotated by BRENDA team
isozyme cPLA2alpha
-
-
Manually annotated by BRENDA team
male Sprague Dawley rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley male rats
-
-
Manually annotated by BRENDA team
Wistar rats
-
-
Manually annotated by BRENDA team
strain A3(2)
-
-
Manually annotated by BRENDA team
strain A-2688
UniProt
Manually annotated by BRENDA team
Streptomyces violaceoruber A-2688
strain A-2688
UniProt
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
isoform IB PLA”
SwissProt
Manually annotated by BRENDA team
isozyme hGIB sPLA2
-
-
Manually annotated by BRENDA team
three isoenzymes
-
-
Manually annotated by BRENDA team
six isoenzymes
-
-
Manually annotated by BRENDA team
Trimorphodon biscutatus lambda
-
-
-
Manually annotated by BRENDA team
formerly Trimeresurus mangshanensis or Ermia mangshanensis
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
-
inhibition of lp-PLA2 activity in conditioned medium by SB435495 or SB480848 significantly decreases lipid accumulation in macrophages
malfunction
-
inhibition of cPLA2 abolishes release of arachidonate but not palmitate from cells treated with fetal bovine serum. Inhibition of PLA2 precludes fetal bovine serum-stimulated formation of lipid droplets. Silenced expression of cPLA2 inhibits the formation of lipid droplets. Inhibition of cPLA2alpha under lipid droplets forming conditions alters endoplasmic reticulum structure
malfunction
-
small interfering RNA knockdown of iPLA2 inhibits superoxide generation by neutrophils
malfunction
-
patient with defects in GIVA PLA2 shows decreases in PLA2 activity, eicosanoid biosynthesis, and the generation of many small intestinal ulcers
malfunction
-
absence of the GIVA PLA2 gene significantly reduces the effects of many inflammatory disease
malfunction
-
progressive inactivation of Lp-PLA2 during low density lipoprotein oxidation leads to an increased uptake of oxidized low density lipoprotein by macrophages, which can be primarily attributed to the increased uptake of the oxidized phospholipids enriched lipid moiety of oxidized low density lipoprotein. Inhibition of Lp-PLA2 activity has no effect on the uptake of ApoB-liposomes conjugates with ApoB isolated from moderately oxidized low density lipoprotein, moderately oxidized low density lipoprotein with inhibited LpPLA2 activity, heavily oxidized low density lipoprotein and heavily oxidized low density lipoprotein with inhibited LpPLA2 activity
malfunction
-
protein kinase D-kinase dead-induced trans-Golgi network tubules are inhibited by phospholipase A2 antagonists
metabolism
-
sPLA2s and Lp-PLA2 produce biologically active metabolites that are involved in several phases of the atherosclerosis process
metabolism
-
hydrolyzes dipalmitoylphosphatidylcholine monolayers in the presence of a supersaturated calcium oxalate subphase, inducing the rapid and plentiful nucleation of calcium oxalate at the lipid interface. Calcium oxalate crystal growth at a ternary monolayer of dipalmitoylphosphatidylcholine, palmitic acid, and a 22-carbon chain lysophospholipid dramatically increases relative to monolayers of just dipalmitoylphosphatidylcholine
physiological function
-
role of PLA2 in the regulation of arachidonic acid and insect platelet activating factor biosynthesis
physiological function
-
PLA2- and autotaxin-mediated de novo lysophosphatidic acid production in the early phase is involved in nerve injury-induced neuropathic pain
physiological function
-
does not show any hemolysis activity in intact erythrocytes. Is active at low surface pressure
physiological function
-
exhibits hemolytic activity in intact erythrocytes and can penetrate phospholipid monolayers at high surface pressure. May be toxic to mammal cells
physiological function
-
does not show any hemolysis activity in intact erythrocytes. Is active at low surface pressure
physiological function
-
does not show any hemolysis activity in intact erythrocytes
physiological function
-
late stage of Golgi assembly occurs via membrane tubules, whose formation is dependent on PLA2 activity and dynein-dependent microtubule transport to complete the process
physiological function
-
iPLA2 is responsible for the enhanced Mn2+ entry occurring upon Ca2+ store depletion, iPLA2 hydrolysis products are involved in the gating of store-operated channels
physiological function
O15496
cPLA2-alpha is the major enzyme responsible for lipid mediator production in human macrophages. cPLA2-alpha is a critical enzyme for the release of arachidonic acid which is then available for conversion to eicosanoids
physiological function
P20474
acidic PLA2-II, in contrast to the basic Asp49 counterparts present in the same venom, lacks myotoxic, cytotoxic, and anticoagulant activities. It does not show hypotensive and anti-platelet aggregation activities and is not lethal to mice at intravenous doses up to 100 microg (5.9 microg/g), indicating its lack of neurotoxic activity. It shows a moderate induction of local edema in vivo. Acidic PLA2-II does not play a key role in the pathophysiology of envenomings, its purpose may be restricted to digestive functions. Acidic and basic PLA2s form two different antigenic groups in venom
physiological function
-
sPLA2 influences the proliferation and/or survival of limb mesenchymal cells. Treatment of wing bud mesenchymal cells with exogenous sPLA2 promotes cell death by activating MMP-9 (matrix metalloproteinase-9) through receptor-mediated signalling and increasing type I collagen degradation. Chondro-inhibitory actions by sPLA2 are prevented by functional blocking of FcRY (chicken yolk sac IgY receptor) and by inhibition of ERK (extracellular-signal-regulated kinase) activity
physiological function
-
PLA2 induces cytotoxic effect on human peripheral lymphocytes. Increased creatine kinase levels (myonecrosis) in the group of mice treated with PLA2
physiological function
-
nPLA reduces infarct volume in rats subjected to focal transient cerebral ischemia and alleviates the neuronal damage in organotypic hippocampal slices subjected to oxygen-glucose deprivation. Staurosporine or oxygen-glucose deprivation mediated apoptotic cell death in astrocytoma cells is reduced by nPLA with a corresponding reduction in caspase 3 activity. Protective effects of nPLA at sub-lethal concentrations of the protein
physiological function
-
lp-PLA2 promotes lipoprotein uptake in macrophages
physiological function
-
sPLA2 activity is present in lumbar cerebrospinal fluid from healthy individuals 20-77 years old that does not depend on either sex or age. Cerebrospinal fluid sPLA2 activity is increased in patients with Alzheimer disease
physiological function
-
sPLA2s (sPLA2-IIA) and Lp-PLA2 are associated with atherogenesis and its complications. Increased levels of these two phospholipases are related with an increase in complex coronary lesions and increase in major cardiovascular clinical events, respectively. sPLA2 may play an important role in atherogenesis by modifying low density lipoprotein particles in the arterial wall, thereby enhancing their aggregation, retention, and macrophage uptake. Cytotoxic compounds from Lp-PLA2 play an important in plaque vulnerability, Lp-PLA2 has a predominantly proinflammatory role in atherogenesis
physiological function
-
cPLA2 alpha plays an important role in the pathogenesis of collagen-induced arthritis. cPLA2 alpha activity increases in hind paws of collagen-induced arthritic mice
physiological function
-
sPLA(2) induces mouse paw oedema
physiological function
-
cPLA2alpha contribution to lipid droplets biogenesis. Overexpression of cPLA2alpha enhances occurrence of lipid droplets. Role in lipid droplets biogenesis is not because of the generation of arachidonic acid, nor is it related to neutral lipid synthesis. cPLA2 is not involved in the synthesis of neutral lipids during lipid droplets biogenesis. cPLA2alpha is not involved in the channeling of extracellular fatty acids into neutral lipids
physiological function
-
cPLA2 may be a potential source of fatty acid hydroperoxides. cPLA2 is a key mediator of the high state 1 Amplex Red signal (thought to be highly specific for hydrogen peroxide) that occurs in response to denervation, most likely by preventing the release of fatty acid hydroperoxides from lipid hydroperoxides in the bilayer. Elevation of cPLA2 is potentially a common phenomenon in mice that exhibit muscle atrophy associated with a loss of innervation
physiological function
-
PLA2 induces caspase-dependent death in human SK-N-SH cells. PLA2 treatment induces Fas and FasL protein expression, leads to activation of p38 MAPK, inactivation of ERK, reactive oxygen species generation and elevation in intracellular Ca2+ concentration. PLA2-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca2+- and reactive oxygen species-evoked p38 MAPK activation, and suggests that non-catalytic PLA2 plays a role for the signaling pathway
physiological function
-
IL-1beta-induced prostaglandin E2 generation is dependent on the up-regulation of cPLA2 expression in tracheal smooth muscle cells
physiological function
-
induces apoptotic death of human leukemia K562 cells in a concentration- and time-dependent manner. Degradation of procaspases, production of tBid, loss of mitochondrial membrane potential, Bcl-2 degradation, mitochondrial translocation of Bax, and cytochrome c release in PLA2-treated cells. PLA2 treatment increases Fas and FasL protein expression and activates p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun NH2-terminal kinase) in K562 cells. SB202190 pretreatment promotes the cytotoxic effect of PLA2 toward K562 cells in a time-dependent manner. SP600125 (JNK inhibitor) abolishes the cytotoxic effect of PLA2 and PLA2-induced autocrine Fas death pathway
physiological function
-
a key role for JNK-mediated cPLA2alpha phosphorylation at Ser505 in the sequence of events leading to translocation and activation of the enzyme to phagosomal membranes in human macrophages
physiological function
-
role of iPLA2 in enhanced superoxide generation in neutrophils from people with diabetes mellitus, iPLA2 presents an alternate pathway independent of protein kinase C and phosphatidic acid phosphohydrolase-1 hydrolase signaling. The iPLA2 does not regulate cell apoptosis or cell death in neutrophils, iPLA2 regulates superoxide generation independently of p47phox or pleckstrin phosphorylation. The iPLA2-derived arachidonic acid activates NAPDH oxidase to generate superoxide anion
physiological function
-
activation of gIVaPLA2 is an essential step in polymophonuclear leukocyte migration in vitro. Change in polymorphonuclear leukocyte cell shape and migration correspond to increased activity of cytosolic gIVaPLA2 and translocation of gIVaPLA2 to the nuclear membrane. F-actin polymerization, another essential step for cell migration, is not regulated by gIVaPLA2
physiological function
-
interaction between hemocytes of bloodsucking bug and Saccharomyces cerevisiae cells is mediated by a rapid generation of arachidonic acid and its products through the action of PLA2
physiological function
-
GIIA PLA2 is a potent antimicrobial agent. Role of the GVIA PLA2 in different signaling pathways. GVIIA PLA2 has anti-inflammatory activity in vivo, is a positive risk factor in coronary heart disease
physiological function
-
GVIA PLA2 plays an important role in bone formation, apoptosis, insulin secretion, and sperm development. GVIA PLA2 in combination with the GIVA PLA2 play an important role in Wallerian degeneration and axon regeneration in nerve injury. GIVA PLA2 is generally considered to be a central enzyme mediating generation of eicosanoids and hence many inflammatory processes
physiological function
-
Lp-PLA2 activity reduces the uptake of oxidized low density lipoprotein by peritoneal macrophages. Lp-PLA2 does not affect the uptake of oxidized low density lipoprotein via the ApoB moiety. Lp-PLA2 reduces the uptake of oxidized low density lipoprotein via the lipid moiety
physiological function
-
adsorption of PLA2 to model membranes is not primarily driven by electrostatic interactions. Subsequent lipid desorption, which is linked to the bilayer-disrupting activity of PLA2, is significantly affected by membrane electrostatics. Specifically, a nonhydrolytic bilayer-disrupting activity of PLA2 targets anionic membranes, triggering a change in bilayer topology
physiological function
-
possible link between increased phospholipase activity, which is associated with hyperoxaluria, and calcium oxalate precipitation
physiological function
B5U6Z2
PLA2 inhibits efficiently tumor cells adhesion and migration. PLA2 is not cytotoxic up to 0.002 mM during 4 days on human cell lines IGR39 (melanoma) and HT1080 (fibrosarcoma). Completely abolishes cell adhesion of IGR39 cells to fibrinogen and fibronectin in a dose-dependent manner, while attachment to laminin-1 and vitronectin is only slightly affected. The enzyme has no effect on type I collagen, integrin-independent substratum and poly-L-lysine. PLA2 abolishes HT1080 cells migration towards fibronectin and fibrinogen in a dose-dependent manner. Anti-tumor effect of PLA2 is mediated by alpha5beta1 and alphav-containing integrins
physiological function
C6YBD6, -
group III sPLA2 may play an important role in the initiation and development of hepatic fibrosis. Expression of collagen III is upregulated in LX-2 cells after incubation with the recombinant protein. Group III sPLA2 can bind to specific sites (specific receptor), not lipids, on LX-2 cells membrane. Group III sPLA2 is a component of excretory-secretory products
physiological function
-
PLA2 signaling pathways indirectly influence the phosphorylation state of Tau
physiological function
-
is involved in the regulation of immune and inflammatory responses
physiological function
-
is a mixed-type inhibitor of thrombin and effectively inhibits thrombin-induced platelet aggregation. Does not require a plasma cofactor, the inhibition is direct. Strongly prolongs the thrombin clotting time (25fold at 0.0000475 mM) with whole human blood plasma. Possesses relatively weak enzymatic activity and is nontoxic to PC12 cells at concentrations up to 0.015 mM, but evokes neurite outgrowth in these cells at a concentration of approximately 0.001 mM, does not impair the adhesion of PC12 cells to plates. At concentrations up to approximately 0.00005 mM, at which the thrombin-clotting time is substantially prolonged, the enzyme exerts no detectable effects on both the intrinsic and extrinsic pathways of the coagulation cascade, thus is a selective thrombin inhibitor. Is at least 2 orders of magnitude less cytotoxic than PLA2 CM2 from Naja kaouthia
physiological function
P00596
does not impair the adhesion of PC12 cells to plates. Is at least 2 orders of magnitude more cytotoxic than thrombin inhibitor from Naja haje
physiological function
-
promutoxin can provoke microvascular leakage in the skin of rats and induce a dose-dependent release of histamine from colon, lung and tonsil from human mast cells in vitro
physiological function
-
the phospholipase A2 toxin I displays a heparin binding C-terminal region, which is probably responsible for the cytotoxic and bactericidal effects. Toxin I is able to induce cytotoxicity on THP-1 cells in vitro as well as lethality in BALB/c mice. Toxin II also induces mild myotoxic effects on mouse skin, but is devoid of hemolytic effects on human erythrocytes up to 0.5 mg/ml
physiological function
-
the functions of 1-CysPrx/aiPLA2 include the protection of cell membrane phospholipids against oxidative damage (peroxidation) and the metabolism (hydrolysis) of phospholipids, such as those of lung surfactant
physiological function
-
ex vivo, whole venom and TX-I phospholipases A2 cause blockade of the neuromuscular transmission in young chick biventer cervicis preparations similar to other isolated snake venom toxins from the Bothrops genus. In vivo, both induce local myotoxicity and systemic interleukin-6 response upon intramuscular injection, additionally, induce moderate footpad edema. In vitro, both induce low cytotoxicity in skeletal muscle myoblasts, however TX-I phospholipases A2 is able to lyse myotubes
physiological function
-
the enzyme does not show myotoxic activity, but induces edema and actively participates in the pathogenesis of snake bite. The enzyme is able to induce increments in interleukin-12p40, TNF-alpha, interleukin-1beta and interleukin-6 levels and no variation of interleukin-8 and interleukin-10 in human peripheral blood mononuclear cells stimulated in vitro, suggesting that the enzyme induces proinflammatory cytokine production by human mononuclear cells
physiological function
-
group X secreted phospholipase A2 (sPLA2) acts as a potent inhibitor of sperm motility that decreases track speed and lateral displacement of the head of both noncapacitated and capacitated sperm. sPLA2 selects a sperm subpopulation for fertilization based on its effect on sperm motility
physiological function
-
the enzyme inhibits the blood coagulation cascade non-enzymatically by binding with coagulation factor Xa, even in the absence of phospholipids and Ca2+ and thus slows down the blood coagulation by partially inhibiting the prothrombin activation
physiological function
-
phospholipase A2 enzymes have an important role in the earliest steps of membrane tubule formation at the trans-Golgi network, which are utilized for membrane trafficking
physiological function
P03135
intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+/-)-3-O-(4-cyanomethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
(+/-)-3-O-(4-hydroxymethylphenyl)-1,2-O-di-n-heptylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
(2'R,2S)-2,3-dihydroxypropyl 2'-octadecanoyloxy-5'-hexadecyloxy-5'-oxopentan-1'-yl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
(2S,2'S,3R)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
(2S,2'S,3S)-2,3-dihydroxypropyl 2',3'-octadecanoyloxy-nonadecyl phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
(3E)-3-[(3aS,7aS)-3-methyl-2-oxo-6-(propan-2-ylidene)hexahydro-1-benzofuran-7(4H)-ylidene]propanoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,5aS,8bR)-3,5a,5b-trimethyl-3a,4,5,5a,5b,8b-hexahydro-2H-cyclopenta[2,3]cyclopropa[1,2-g]benzofuran-2,6(3H)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,5aS,9bR)-3,5a,9-trimethyl-3a,4,5,5a-tetrahydronaphtho[1,2-b]furan-2,8(3H,9bH)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,8S,9bS)-6,8-dihydroxy-3,6,9-trimethyl-3,3a,4,5,6,6a,7,8-octahydroazuleno[4,5-b]furan-2(9bH)-one + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,8S,9bS)-8-hydroxy-3,6,9-trimethyl-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,9bS)-3,6,9-trimethyl-2,8-dioxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate + H2O
?
show the reaction diagram
-
-
-
-
?
(3R,3aS,6R,9bS)-6-hydroxy-3,6,9-trimethyl-3a,4,5,6,6a,7-hexahydroazuleno[4,5-b]furan-2,8(3H,9bH)-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(3S)-5a-(1-bromo-1-methylethyl)-3-methyl-3,3a,5,5a,8,9b-hexahydro-4H-furo[2,3-f]chromene-2,7-dione + H2O
?
show the reaction diagram
-
-
-
-
?
(R)-1,2-dipalmitoyl-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
(R)-1,2-dipalmitoyl-glycero-3-phosphoglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
(R)-1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
enzyme adsorbs to monolayers of L-alpha-1,2-dipalmitoyl-sn-glycero-3-phosphocholine, leading to hydrolysis of the monlayer
-
-
?
(R)-1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phoshocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-bis(heptanoylthio)-glycerophosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-bis-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
-
-
-
-
?
1,2-bis-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(10-pyrenedecanoyl)-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
P00630
-
-
-
?
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
1-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid
show the reaction diagram
-
fluorescent substrate
-
?
1,2-bis-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-undecanoyl)-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-di-O-hexadecyl-sn-glycerol-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoate
show the reaction diagram
-
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphate + H2O
1-acyl-sn-glycero-3-phosphate + a carboxylate
show the reaction diagram
-
substrate from soybean
-
-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
1-acyl-sn-glycero-3-phosphatide + fatty acid
show the reaction diagram
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
1-acyl-sn-glycero-3-phosphatide + fatty acid
show the reaction diagram
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-diacyl-sn-glycero-3-phospho-(1-D-myo-inositol) + H2O
1-acyl-sn-glycero-3-phospho-(1-D-myo-inositol) + a carboxylate
show the reaction diagram
-
substrate from soybean
-
-
?
1,2-diacyl-sn-glycero-3-phosphocholine + H2O
1-acyl-sn-glycero-3-phosphocholine + a carboxylate
show the reaction diagram
-
substrate from soybean
-
-
?
1,2-diacyl-sn-glycero-3-phosphorylcholine + H2O
1-acyl-sn-glycero-3-phosphorylcholine + fatty acid
show the reaction diagram
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphorylcholine + H2O
1-acyl-sn-glycero-3-phosphorylcholine + fatty acid
show the reaction diagram
-
-
-
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
-
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
?
1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
?
1,2-didodecanoyl-sn-glycero-3-phosphocholine + H2O
1-decanoyl-sn-glycero-3-phosphocholine + decanoate
show the reaction diagram
-
-
-
?
1,2-diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O
1-heptanoyl-sn-glycero-3-phosphocholine + heptanoate
show the reaction diagram
-
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-sulfate + H2O
1-heptanoyl-sn-glycero-3-sulfate + heptanoate
show the reaction diagram
-
-
-
?
1,2-dihexadecanoyl-rac-glycero-3-phosphorac-(1-glycerol) + H2O
?
show the reaction diagram
-
pyrene-modified or unmodified phospholipid substrate
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1-hexanoyl-sn-glycero-3-phosphocholine + hexanoate
show the reaction diagram
-
low activity
-
-
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laureate
show the reaction diagram
-
-
-
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laureate
show the reaction diagram
-
-
-
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laureate
show the reaction diagram
-
-
-
?
1,2-dilauroyl-sn-glycero-3-phosphocholine + H2O
1-lauroyl-sn-glycero-3-phosphocholine + laurate
show the reaction diagram
-
-
-
-
?
1,2-dilinoleoyl-phosphatidylcholine + H2O
1-linoleoyl-sn-glycero-3-phosphocholine + linoleic acid
show the reaction diagram
-
-
-
-
?
1,2-dilinoleoyl-sn-glycero-3-phosphocholine + H2O
1-linoleoyl-sn-glycero-3-phosphocholine + linoleoate
show the reaction diagram
-
-
-
-
?
1,2-dimyristol-sn-glycero-phosphomethanol lithium salt + H2O
myristic acid + 1-myristoyl-sn-glycerophosphomethanol
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-glycero-3 phosphocholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
-
?
1,2-dimyristoyl-sn-glycero-3-phosphocholine + H2O
1-myristoyl-sn-glycero-3-phosphocholine + myristate
show the reaction diagram
-
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylcholine + H2O
1-myristoyl-phosphorylcholine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylinositol + H2O
1-myristoyl-sn-phosphatidylinositol + myristic acid
show the reaction diagram
-
-
-
?
1,2-dimyristoyl-sn-phosphatidylserine + H2O
1-myristoyl-sn-phosphatidylserine + myristic acid
show the reaction diagram
-
-
-
?
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O
1-nonanoyl-sn-glycero-3-phosphocholine + nonanoate
show the reaction diagram
-
-
-
?
1,2-dinonanoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
show the reaction diagram
P00592
micellar substrate
-
?
1,2-dioctanoyl-sn-glycero-3-phosphoglycol + H2O
1-octanoyl-sn-glycero-3-phosphoglycol + octanoate
show the reaction diagram
-
-
-
?
1,2-dioleoyl-L-alpha-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
preferred substrate
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoylglycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
1-oleoyl-sn-glycero-3-phosphoethanolamine + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphorac-(1-glycerol) + H2O
1-oleoyl-sn-glycero-3-phosphorac-(1-glycerol) + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoserine + H2O
1-oleoyl-sn-glycero-3-phosphoserine + oleate
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
1-oleoyl-sn-glycerol + oleic acid
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-phosphatidylcholine + H2O
1-oleoyl-sn-phosphatidylcholine + oleate
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylcholine + H2O
1-oleoyl-sn-phosphatidylcholine + oleate
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylcholine + H2O
1-oleoyl-sn-phosphatidylcholine + oleate
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
-
-
?
1,2-dioleoyl-sn-phosphatidylethanolamine + H2O
1-oleoyl-sn-phosphatidylethanolamine + oleic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-L-3-phosphatidylcholine + H2O
1-palmitoylphosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
data for iPLA2
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
-
hydrolyzes the sn-2 position of a phospholipid liberating a fatty acid and a lysolipid
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-phosphatidylcholine + palmitate
show the reaction diagram
Q8S8N6
in sn-2 position, linoleate is preferred over palmitate
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + palmitate
show the reaction diagram
O96100
substrate from egg yolk
-
-
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphatidylethanolamine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphatidylethanolamine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-phosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphoethanolamine + palmitate
show the reaction diagram
O96100
substrate from egg yolk
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
P00630
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoylglycerophosphocholine + palmitic acid
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-phosphatidylinositol 4,5-bisphosphate + H2O
1-palmitoyl-sn-glycero-3-phosphoethanolamine-N-phosphatidylinositol 4,5-bisphosphate + palmitic acid
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-glycero-3-phosphoglycerol + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + palmitate
show the reaction diagram
P00630
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitic acid
show the reaction diagram
-
in mixed micelles with Triton X-100
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + palmitate
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-phosphatidylserine + H2O
1-palmitoyl-sn-phosphatidylserine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dipalmitoyl-sn-phosphatidylserine + H2O
1-palmitoyl-sn-phosphatidylserine + palmitic acid
show the reaction diagram
-
-
-
?
1,2-dithio-deheptanoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
1,2-dithio-heptanoylphosphatidylcholine + H2O
?
show the reaction diagram
-
detection of reaction product with 5,5'-dithio-bis-(2-nitrobenzoic acid)
-
-
?
1-acryl-2(N-4-nitrobenzo-2-oxo-1,3-diazole)aminocapryl-phosphatidylcholine + H2O
1-acrylglycerophosphocholine + (N-4 nitrobenzo-2-oxo,1,3-diazole)-aminocaproic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-acyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glycerol phosphoethanolamine + H2O
1-acyl-sn-glycerol phosphoethanolamine + arachidonate
show the reaction diagram
-, P47712
radiolabeled substrate
-
-
?
1-acyl-2-arachidonoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glyerophosphoethanolamine + H2O
1-acyl-sn-glyerophosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glyerophosphoethanolamine + H2O
1-acyl-sn-glyerophosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-arachidonoyl-sn-glyerophosphoethanolamine + H2O
1-acyl-sn-glyerophosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
1-acyl-3-phosphoethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
1-acyl-3-phosphoethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-3-phosphoethanolamine + H2O
1-acyl-3-phosphoethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-glycerophosphocholine + H2O
1-acyl-glycerophosphocholine + linolic acid
show the reaction diagram
-
-
-
?
1-acyl-2-linoleoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + linoleic acid
show the reaction diagram
-
-
-
?
1-acyl-2-oleoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-acyl-2-palmitoyl-sn-glycerophosphocholine + H2O
1-acyl-sn-glycerophosphocholine + palmitic acid
show the reaction diagram
-
-
-
?
1-decanoyl-2-(4-nitrophenylglutaryl)glycerol 3-phosphate + H2O
?
show the reaction diagram
-
HSD-PLA2
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphatidic acid + H2O
?
show the reaction diagram
-
group V sPLA2
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphocholine + 1-pyrenedecanoate
show the reaction diagram
-
group V sPLA2
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoethanolamine + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoethanolamine + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
-
group V sPLA2
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + 1-pyrenedecanoate
show the reaction diagram
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + 1-pyrenedecanoate
show the reaction diagram
-
group V sPLA2
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-glycero-3-phosphoserine + H2O
1-hexadecanoyl-glycero-3-phosphoserine + 1-pyrenedecanoate
show the reaction diagram
-
group V sPLA2
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
fluorometric determination
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O
?
show the reaction diagram
-
micellar substrate
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-sn-glycero-3-phosphoglycerol + 1-pyrenedecanoic acid
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphogylcerol + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 1-pyrenedecanoate
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphatidyl choline + H2O
?
show the reaction diagram
C0LTQ2, -
-
-
-
?
1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-(10-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O
1-hexadecanoyl-glycero-3-phosphoethanolamine + 10-pyrenedecanoate
show the reaction diagram
-
-
-
-
?
1-hexadecanoyl-2-9(cis)-octadecanoyl-rac-glycero-phosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-hexadecanoyl-glycero-3-phosphoglycerol + acetate
show the reaction diagram
-
i.e. PAF or platelet activating factor
-
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
show the reaction diagram
Q13093
i.e. platelet-activating factor
-
-
?
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O
1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O
1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-O-hexadecyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
-
-
?
1-O-hexadecyl-2-[(cis)-9-octadecenoyl]-rac-glycero-3-phosphocholine + H2O
1-O-hexadecyl-rac-glycero-3-phosphocholine + cis-9-octadecenoate
show the reaction diagram
-
-
-
?
1-oleoyl-2-isolauroyl phosphatidylethanolamine + H2O
1-oleoyl phosphatidylethanolamine + isolauric acid
show the reaction diagram
-
-
-
?
1-oleoyl-2-palmitoyl-phosphatidylcholine + H2O
1-oleoyl-phosphatidylcholine + palmitic acid
show the reaction diagram
-
-
-
?
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
1-oleoyl-2-stearoyl-sn-glycero-3-phosphocholine + H2O
1-oleoyl-sn-glycero-3-phosphocholine + stearate
show the reaction diagram
-
-
-
-
?
1-oleoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(10-pyrenyldecanoyl)-sn-glycero-3-phosphate + H2O
10-pyrenyldecanoic acid + 1-palmitoyl-sn-glycero-3-phosphate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-(12-(3-(4-hydroxyphenyl)propionyl)amino dodecanoyl)phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphorylcholine + 12-(3-(4-hydroxyphenyl)propionyl)amino dodecanoate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
isoform cPLA2-beta and cPLA2-gamma hydrolyse this substrate at a lower rate than isoform cPLA2-alpha
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-glycero-3-phosphoglycerol + arachidonate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + arachidonic acid
show the reaction diagram
-
in mixed micelles with Triton X-100
-
?
1-palmitoyl-2-arachidonoylglycerophosphocholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
GIVA cPLA2 substrate and GIVA iPLA2
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
cPLA2 cleaves selectively arachidonoyl phospholipids
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
substrate for measurement of PLA1-activity of the 80-kDa PLA2
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
,data for iPLA2
-
?
1-palmitoyl-2-arachidonoylphosphatidylethanolamine
1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid
show the reaction diagram
O60733
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylethanolamine
1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-arachidonylphosphocholine + H2O
1-palmitoyl-glycerophosphocholine + arachidonic acid
show the reaction diagram
O77793
-
-
?
1-palmitoyl-2-arachidonylphosphoethanolamine + H2O
1-palmitoyl-glycerophosphoethanolamine + arachidonic acid
show the reaction diagram
O77793
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidic acid + H2O
1-palmitoyl-sn-glycero-3-phosphate + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + linoleate
show the reaction diagram
Q8S8N6
in sn-2 position, linoleate is preferred over palmitate
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylethanolamine + H2O
1-palmitoyl-sn-glycerophosphoethanolamine + linoleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylethanolamine + H2O
1-palmitoyl-phosphoethanolamine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylinositol + H2O
1-palmitoyl-3-phosphoinositol + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-phosphatidylserine + H2O
1-palmitoyl-sn-glycero-3-phosphoserine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linoleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoyl-sn-glycerophosphorylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linoleic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
Q9M0D7
-
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
-
group V sPLA2
-
?
1-palmitoyl-2-linoleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + linolic acid
show the reaction diagram
-
iPLA2
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-linoleoylphosphatidylethanolamine + H2O
1-palmitoyl-glycerophosphorylethanolamine + linolic acid
show the reaction diagram
-
data for iPLA2
-
?
1-palmitoyl-2-linoleoylphosphocholine + H2O
1-palmitoyl-glycerophosphocholine + linolic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
1-palmitoylphosphocholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylethanolamine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-phosphatidylinositol + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-rac-(1-glycerol) + H2O
1-palmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
oleic acid + 1-palmitoyl-sn-glycero-3-phosphocholine
show the reaction diagram
-
from egg yolk
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphorylcholine + oleate
show the reaction diagram
P00630
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-glycero-3-phosphoglycerol + oleate
show the reaction diagram
-
preferred substrate
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphoglycerol + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
1-palmitoyl-sn-glycero-3-phosphorylglycerol + oleate
show the reaction diagram
P00630
-
-
-
?
1-palmitoyl-2-oleoylglycerophosphocholine + H2O
?
show the reaction diagram
-, Q9XG81
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
show the reaction diagram
-
data for iPLA2
-
?
1-palmitoyl-2-palmitoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
show the reaction diagram
Q9M0D7
-
-
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-2-stearoyl-dibromo-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
P00630
-
-
-
?
1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
preferred substrate
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
good substrate
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonate
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonate
show the reaction diagram
-
1-stearoyl-2-[14C]arachidonoyl-sn-glycero-3-phosphocholine
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-stearoyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O
1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O
1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
data for iPLA2
-
?
1-stearoyl-2-arachidonoylphosphatidylcholine + H2O
1-stearoyl-glycerophosphorylcholine + arachidonic acid
show the reaction diagram
-
cPLA2 cleaves selectively arachidonoyl containing phospholipids
-
?
1-stearoyl-2-arachidonyl-phosphatidylinositol 4,5-bisphosphate + H2O
1-stearoyl-sn-glycero-3-phosphoinositol 4,5-bisphosphate + arachidonic acid
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-arachidonylphosphocholine + H2O
1-stearoyl-glycerophosphocholine + stearic acid
show the reaction diagram
O77793
-
-
?
1-stearoyl-2-linolenoyl-sn-glycerol-3-phosphocholine + H2O
?
show the reaction diagram
-
preferred substrate
-
?
1-stearoyl-2-linoleoyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + linoic acid
show the reaction diagram
-
-
-
?
1-stearoyl-2-oleoyl-3-sn-glycerophosphorylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-stearoyl-2-palmitoyl-sn-glycerol-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + palmitic acid
show the reaction diagram
-
-
-
?
4-nitro-3-(octanoyloxy) benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
-
-
-
-
?
4-nitro-3-(octanoyloxy) benzoic acid + H2O
4-nitrobenzoate + octanoate
show the reaction diagram
-
-
-
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
-
-
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
Trimorphodon biscutatus lambda
-
-
-
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
3-hydroxy-4-nitrobenzoate + octanoate
show the reaction diagram
-
synthetic substrate
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
?
show the reaction diagram
Q8QG87
-
-
-
?
4-nitro-3-(octanoyloxy)benzoic acid + H2O
?
show the reaction diagram
-
a synthetic chromogenic substrate
-
-
?
4-nitro-3-octanoyloxy-benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitro-3-octanoyloxy-benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitro-3-octanoyloxybenzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitro-3-octanoyloxybenzoic acid + H2O
?
show the reaction diagram
P24605
-
-
-
?
4-nitrophenyl caprate + H2O
4-nitrophenol + capric acid
show the reaction diagram
-
-
-
?
6-dodecanoyl-2-dimethylaminonaphthalene + H2O
?
show the reaction diagram
-
-
-
-
?
acrylodan-labeled fatty acid-binding protein + H2O
?
show the reaction diagram
-
-
-
-
?
arachidonyl thio-PC + H2O
arachidonic acid + (7R)-4-hydroxy-N,N,N-trimethyl-7-sulfanyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide
show the reaction diagram
-
-
-
-
?
arachidonyl thio-PC + H2O
arachidonic acid + (7R)-4-hydroxy-N,N,N-trimethyl-7-sulfanyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide
show the reaction diagram
-
-
-
-
?
cardiolipin + H2O
?
show the reaction diagram
-
-
-
-
-
choline plasmalogen + H2O
lysoplasmalogen + fatty acid
show the reaction diagram
-
-
-
?
D,L-alpha-dipalmitoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
DBPA + H2O
?
show the reaction diagram
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPC + H2O
?
show the reaction diagram
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPE + H2O
?
show the reaction diagram
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPG + H2O
?
show the reaction diagram
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
diarachidonylphosphatidylcholine + H2O
arachidonylphosphatidylcholine + arachidonic acid
show the reaction diagram
-
-
-
?
diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
-
-
-
?
dihexanoyl-dithio-phosphatidylcholine + H2O
?
show the reaction diagram
P00592
proPLA2, monomeric substrate
-
-
?
dioctanoyl phosphatidylcholine + H2O
octanoyl phosphatidylcholine + octanoate
show the reaction diagram
-
-
-
?
dioleoyl phosphatidylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
dioleoyl phosphatidylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + palmitic acid
show the reaction diagram
-
GIVA iPLA2 and GV sPLA2
-
-
?
diphosphatidylglycerol + H2O
?
show the reaction diagram
-
-
-
-
?
egg yolk + H2O
?
show the reaction diagram
-
-
-
-
?
egg yolk + H2O
?
show the reaction diagram
-
-
-
-
?
egg yolk + H2O
?
show the reaction diagram
-
Scol/Pla contains conserved residues in positions His46, Asp47 and Tyr50 found to be important for the catalytic activity, and contains five disulfide bridges
-
-
?
egg yolk phospholipid + H2O
?
show the reaction diagram
P20474
-
-
-
?
ethanolamine plasmalogen + H2O
lysoplasmalogen + fatty acid
show the reaction diagram
-
-
-
?
glycerophospholipid + H2O
arachidonic acid + ?
show the reaction diagram
-
-
-
-
?
hen egg phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
L-1-acyl-2-arachidonyl-sn-glycerol-3-phosphatidylethanolamine + H2O
?
show the reaction diagram
-
-
-
?
L-alpha-dipalmitoyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
?
L-alpha-dipalmitoyl phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
L-alpha-phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
L-dipalmitoyl phosphatidylcholine + H2O
1-palmitoyl-sn-glycerophosphocholine + palmitate
show the reaction diagram
-
-
-
-
?
L-dipalmitoyl-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized high density lipoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized low density lipoprotein + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized palmitoyl arachidonyl phosphatidylcholine + H2O
?
show the reaction diagram
-
-
-
-
?
oxidized phosphatidylcholine + H2O
lysophosphatidylcholine + fatty acid
show the reaction diagram
-
-
-
-
-
oxidized phosphatidylcholine + H2O
lysophosphatidylcholine + fatty acid
show the reaction diagram
-
great amount of oxidized phosphatidylcholine of oxidized LDL is hydrolyzed at the sn-2 position
-
-
?
oxidized phosphatidylcholines + H2O
1-acylglycerophosphocholine + oxidized fatty acids
show the reaction diagram
-
-
-
?
oxidized phosphatidylcholines + H2O
1-acylglycerophosphocholine + oxidized fatty acids
show the reaction diagram
-
oxidized 1-palmitoyl-2-arachidonoylphosphatidylcholine for substrate
-
?
oxidized phosphatidylcholines + H2O
1-acylglycerophosphocholine + oxidized fatty acids
show the reaction diagram
-
HSD-PLA2
-
?
p-nitrophenyl laurate + H2O
p-nitrophenol + laurate
show the reaction diagram
-
23.7% of the activity with p-nitrophenyl propionate
-
-
?
p-nitrophenyl octanoate + H2O
p-nitrophenol + octanoic acid
show the reaction diagram
-
79.5% of the activity with p-nitrophenyl propionate
-
-
?
p-nitrophenyl propionate + H2O
p-nitrophenol + propionate
show the reaction diagram
-
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
palmitoyl-sn-glycerophosphocholine + oleate
show the reaction diagram
-, Q5CCT8
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
palmitoyl-sn-glycerophosphoethanolamine + oleate
show the reaction diagram
-, Q5CCT8
-
-
-
?
palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol + H2O
palmitoyl-sn-glycerophosphoglycerol + oleate
show the reaction diagram
-, Q5CCT8
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
-
-
-
?
phosphatidic acid + H2O
1-acylglycerophosphate + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + arachidonic acid
arachidonoyl phosphatidylcholine
show the reaction diagram
-
-
-
r
phosphatidylcholine + H2O
?
show the reaction diagram
-
the enzyme shows preferential hydrolysis of phosphatidylcholine
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
P00592
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-, Q8JIY9
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
Lapemis hardwickii
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
from egg yolk
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
kinetic investigation of hydrophobic/hydrophilic effect in various W7O microemulsions, using isooctane as main solvents and alcohols from 1-butanol to 1-octanol as co-solvent
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
show the reaction diagram
-
preferred substrate for both isoenzymes, NK-PLA2-I and NK-PLA2-II
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
O96100
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
C6YBD6, -
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
substrate is derived from egg yolk
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
substrate is derived from human carotid artery plaques
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
in the presence of substrate, the enzyme binds to the interface as an active form. This crucial step is mediated by a planar surface region of the protein. The corresponding hydrophobic surface involves hydrophobic residues (Leu2, Trp3, Phe19, Leu20, Leu31, Ile64, Leu65, Tyr69, Ile72, Tyr75, and Leu118), hydrophobic surface involved in lipid binding increases
-
-
?
phosphatidylcholine + linoleic acid
lineoyl phosphatidylcholine
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + arachidonic acid
arachidonoyl phosphatidylethanolamine
show the reaction diagram
-
-
-
r
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylethanolamine + H2O
1-acylglycerophosphorylethanolamine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylethanolamine + linoleic acid
lineoyl phosphatidylethanolamine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
-
-
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylglycerol + H2O
1-acylglycerol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylinositol + arachidonic acid
arachidonoyl phosphatidylinositol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylinositol + arachidonic acid
arachidonoyl phosphatidylinositol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylinositol + linoleic acid
lineoyl phosphatidylinositol + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + arachidonic acid
arachidonoyl phosphatidylserine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + H2O
1-acylglycerophosphoserine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + H2O
1-acylglycerophosphoserine + fatty acid
show the reaction diagram
-
-
-
?
phosphatidylserine + H2O
1-acylglycerophosphoserine + fatty acid
show the reaction diagram
-
-
-
-
?
phosphatidylserine + linoleic acid
lineoyl phosphatidylserine + fatty acid
show the reaction diagram
-
-
-
?
phospholipid + H2O
lysophospholipid + fatty acid
show the reaction diagram
P47713
-, the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
P00592
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
aldosterone-dependent sodium transport
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac contraction and excitation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac contraction and excitation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
signal transduction
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
O60733
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
allergenic
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
cancer
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
Lp-PLA2 rapidly degrades oxidatively modified phospholipids in modified low density lipoprotein leading to formation of proinflammatory and cytotoxic products (i.e. lysophosphatidylcholine) and oxidized nonesterified fatty acids
-
-
?
pigment epithelium-derived 6 + H2O
?
show the reaction diagram
-
i.e. PED6, a synthetic substrate
-
-
?
plasmalogen + H2O
?
show the reaction diagram
-
-
-
-
?
platelet activating factor + H2O
?
show the reaction diagram
-
-, PAF i.e. platelet activating factor, HSD-PLA2
-
-
?
platelet activating factor + H2O
?
show the reaction diagram
-
hGX sPLA2 hydrolyzes platelet activating factor, which is a reaction catalyzed by the platelet activating factor-acetylhydrolase, EC 3.1.1.47
-
-
?
platelet activating factor + H2O
lyso-platelet activating factor
show the reaction diagram
-
-
-
-
?
rac-1,2-dihexanoyldithiopropyl-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
sn-2-arachidonyl phosphatidylcholine + H2O
phosphatidylcholine + arachidonate
show the reaction diagram
-
-
-
-
?
sn-3-phosphatidylcholine + H2O
?
show the reaction diagram
P20474
-
-
-
?
soya lecithin + H2O
?
show the reaction diagram
P59071
-
-
-
?
l-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
Q9M0D7
activity is slightly higher when the acyl group of phosphatidylcholine is a linoleoyl group rather than a palmitoyl group at the sn-2 position
-
?
additional information
?
-
-
cleaves fatty acids at the sn-2 and sn-2 positions of phosphatidylcholine
-
?
additional information
?
-
-
enzyme exhibits lyspohospholipase activity, lysophospholipid transacylase acitivty and phospholipase A2 activity
-
?
additional information
?
-
-
enzyme has higher phospholipase activity than PLA2 activity, sequentially hydrolyzes fatty acid from the sn-2 and sn-1 positions of phosphatidylcholine
-
?
additional information
?
-
Bothrops spp.
-
enzyme has indirect haemolytic, anticoagulant, myotoxic and cytotoxic activity
-
?
additional information
?
-
-
enzyme is a D49K variant and lacks hydrolytic activity
-
?
additional information
?
-
-
enzyme is active towards mono-acyl-glycerolphosphocholines, increasing activity with increasing chain lengths from C12 to C16
-
?
additional information
?
-
-
enzyme prefers phosphocholine to ethanolamine and unsaturated fatty acids to saturated fatty acids at sn-2 position of the phospholipids
-
?
additional information
?
-
-
substrate: egg yolk emulsion
-
?
additional information
?
-
-
anticoagulant and haemolytic activity
-
?
additional information
?
-
-
damages membranes by a noncatalytic Ca2+-independent mechanism
-
?
additional information
?
-
-
enzyme causes myotoxicity but no significant neurotoxicity
-
?
additional information
?
-
-
enzyme has cytotoxic activity and can lyse erythrocytes
-
?
additional information
?
-
-
enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells
-
?
additional information
?
-
-, Q8JIY9
induces edema, has haemolytic activity and inhibits ADP-induced rabbit platelet aggregation
-
?
additional information
?
-
-
induces pharmacological effects, including myotoxic or anticoagulant effects, and insulin secretion stimulating effects through a non-enzymatic mechanism
-
?
additional information
?
-
-
inhibits platelet aggregation induced by collagen and ADP
-
?
additional information
?
-
-
involved in mast cell degranulation, creatinine kinase release, causes edema and myonecrosis, edema induction is not dependent on the catalytic activity if the enzyme
-
?
additional information
?
-
-
involved in synaptic plasticity, generation of second messengers, axon regeneration and neurodegeneration
-
?
additional information
?
-
-
role in mediating fatty acid release from intact cells
-
?
additional information
?
-
-
role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface
-
?
additional information
?
-
-
role in the release of linolenic acid
-
?
additional information
?
-
-
SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema
-
?
additional information
?
-
-
stimulates CD11b translocation from the PMN granule store to the plasma membrane and enhances neutrophil motility on collagen-coated surfaces, first causes a non-enzymatic stimulation of PMN leading to the activation of cytosolic PMN PLA2 production and of arachidonate metabolites involved in stimulation of PMN degranulation and motility
-
?
additional information
?
-
-
stimulates CD11b translocation from the polymorph nuclear granule store to the plasma membrane and enhances neutrophil motility on collagen-coated surfaces, first causes a non-enzymatic stimulation of PMN leading to the activation of cytosolic PMN PLA2 production and of arachidonate metabolites involved in stimulation of PMN degranulation and motility
-
?
additional information
?
-
-
ExoU is a potent phospholipase virulence factor that is translocated into the cytosol by type III secretion system
-
-
-
additional information
?
-
-
both isoenzymes NK-PLA2-I and NK-PLA2-II cause significantly more damage to mitochondrial membranes as compared to erythrocyte membranes
-
-
-
additional information
?
-
-
despite all features of a class II phospholipase A2, enzyme does not show phospholipase and hemorrhagic activity, but weak toxic and anticoagulant activity
-
-
-
additional information
?
-
-
enzyme causes a significant concentration-dependent neuromuscular blockade in the chick biventer cervicis preparation
-
-
-
additional information
?
-
-
enzyme extracts cause vacuolating and cytolytic effects on Chinese hamster ovary cells in tissue culture
-
-
-
additional information
?
-
-
enzyme has hemolytic activity with red blood cells, which is greatly inhibited by phosphatidylcholines
-
-
-
additional information
?
-
-
enzyme induces hemolysis when incubated with exogenous lecithin
-
-
-
additional information
?
-
-
enzyme inhibits platelet aggregation which is induced by 1 mmol/l ADP, with IC50 of 6 mmol/l
-
-
-
additional information
?
-
-
enzyme is a class B1 platelet aggregation inhibitor and inhibits platelet aggregation induced by ADP, collagen and epinephrine
-
-
-
additional information
?
-
-
enzyme is toxic to mice with a LD50 value of 0.098 mg/kg body weight, producing acute neurotoxic symptoms. It is weakly coagulant and devoid of cytotoxicity, myotoxicity, hemorrhage, edema inducing, and direct lytic activities
-
-
-
additional information
?
-
Micrurus dumerilii carinicauda
-
enzyme produces neuromuscular blockade in vertebrate nerve-muscle preparations without involving cholinergic nicotinic receptors
-
-
-
additional information
?
-
-
enzymes show post-synaptic neurotoxicity, they are toxic to mice with LD50 of 1.9-2.1 mg/kg body weight
-
-
-
additional information
?
-
-
enzyme does not show fatty acid specificity, but prefers phosphatidylcholine over phosphatidylethanolamine
-
-
-
additional information
?
-
-
isoenzyme NK-PLA2-I does not discriminate between saturated and unsaturated fatty acids whereas isoenzyme NK-PLA2-II shows a preference for unsaturated fatty acids
-
-
-
additional information
?
-
-
no substrate: p-nitrophenyl palmitate, p-nitrophenyl stearate
-
-
-
additional information
?
-
-
preference of substrates in decreasing order: phosphatidylcholines, phosphatidylglycerols, phosphatidylethanolamines, phosphatidic acids
-
-
-
additional information
?
-
-
preference of substrates in decreasing order: phosphatidylglycerols, phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids
-
-
-
additional information
?
-
-
preference of substrates in decreasing order: phosphatidylglycerols, phosphatidylethanolamines, phosphatidylcholines, phosphatidic acids
-
-
-
additional information
?
-
P24605
BaTX induces myonecrosis and edema in vivo in mice upon intramuscular or subcutaneous injection, respectively, in vitro, the enzyme rapidly lysed skeletal muscle myoblasts, and causes a potent blockade of neuromuscular transmission in young chicken biventer cervicis preparations, overview
-
-
-
additional information
?
-
-
bile salt regulation of lipid metabolism via both activation and inhibition of PLA2, interaction and binding structure analysis, overview
-
-
-
additional information
?
-
-
crotoxin, a potent neurotoxin from the venom of the Brazilian rattlesnake, exists as a heterodimer formed between a phospholipase A2 and a catalytically inactive acidic phospholipase A2 analogue crotapotin, overview
-
-
-
additional information
?
-
-, P20474
CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
-
-
-
additional information
?
-
-
during apoptosis, changes occur in lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A2, mechanism, the membranes of apoptotic cells become susceptible to sPLA2 through a reduction in lipid-neighbor interactions that facilitates migration of phospholipids into the enzyme active site, overview
-
-
-
additional information
?
-
-
exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
infection by ExoU-producing Pseudomonas aeruginosa induces a rapid release of arachidonic acid as well as a significant release of prostaglandins PGE2 and PGI2 from human endothelial cells of the HMEC-1 line, overview, ExoU may contribute to Pseudomonas aeruginosa pathogenesis by inducing an eicosanoid-mediated inflammatory response of host organisms, overview
-
-
-
additional information
?
-
Q8QG87
isozymes BinTx-I and BinTx-II show myotoxic activity in mice skeletal muscle and contribute to the neuromuscular activity of venom, overview
-
-
-
additional information
?
-
-
PLA2s affect cellular activation, signal transduction, and possibly innate immunity, the specific secretory isozyme sPLA2-X neutralizes human immunodeficiency virus type 1 through degradation of the viral membrane, the catalytic function is required for antiviral activity, the target cells of infection are unaffected, sPLA2-X potently reduces gene transfer of HIV-1 Env-pseudo-typed lentivirus vectors and inhibits the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4 T cells. Virions resistant to damage by antibody and complement were sensitive to lysis by sPLA2-X, mechanism, overview
-
-
-
additional information
?
-
-
Pseudomonas aeruginosa PLA2 is involved in induction of polymorphonuclear cell migration across lung epithelial barriers in hosts, e.g. A549 alveolar epithelial cells, mediated by epithelial production of the eicosanoid hepoxilin A3, HXA3, in response to Pseudomonas aeruginosa infection, HXA3 is a polymorphonuclear cell, PMN, chemoattractant metabolized from arachidonic acid, overview
-
-
-
additional information
?
-
-
the enzyme is a component of the venom and causes cytotoxic lesions in murine skeletal muscle C2C12 myoblasts and myotubes, overview
-
-
-
additional information
?
-
-
the isozymes are neurotoxic and lethal, with the acidic isozyme DrK-aI being the most active toxin, overview
-
-
-
additional information
?
-
Q13093
the lipoprotein-associated PLA2 plays a crucial role in atherosclerosis, and is proposed as a promising target for drug discovery
-
-
-
additional information
?
-
-
the PLA2, i.e. RVV-7, is the basic toxin of Russell’s viper venom, it shows cytotoxic activity with B16F10 melanoma cells, it inhibits trypsin, but not chymotrypsin or bromelain, overview
-
-
-
additional information
?
-
P84776, -
zhaoermiatoxin induces oedema and strong myonecrosis without detectable PLA2 catalytic activity, overview
-
-
-
additional information
?
-
-, P58399
binding of 4-bromophenacyl bromide and alpha-tocopherol and alpha-tocopherol acetate inhibitors by PrTX-1 involves His48
-
-
-
additional information
?
-
-
hGX sPLA2 prefers phosphatidylcholine 50fold to 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine as substrate, its hydrolyzing activity towards platelet activating factor rises abruptly when the concentration of the substrate passes through its critical micelle concentration, overview
-
-
-
additional information
?
-
-
long chain oxidized phosphatidylcholines represent quantitatively the most abundant phosphatidylcholine products of LDL oxidation, although they are less efficient as substrates for Lp-PLA2 than are the short chain oxidized phosphoatidylcholines
-
-
-
additional information
?
-
O96100
relationship between polar-group specificity and structure of the pancreatic loop region, overview
-
-
-
additional information
?
-
-
structural and functional effects of tryptophans inserted into the membrane-binding and substrate-binding sites of human group IIA phospholipase A2, overview
-
-
-
additional information
?
-
-
substrate specificity, overview, Lpla2 also shows transacylase activity transferring fatty acids from phosphatidylcholine or phosphatidylethanolamine liposomes onto N-acetylsphingosine incorporated into phospholipid liposomes, positional specificity, overview
-
-
-
additional information
?
-
-
substrate specificity, overview, substrate application in micelles, no activity with 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, AtsPLA2-alpha prefers zwitterionic phospholipids, and shows lower activity toward anionic phospholipids, in substrates with two identical fatty acid chains, AtsPLA2-alpha shows optimum activity toward phospholipids with decanoyl groups, in substrates with palmitoyl groups in sn-1 position, acyl chains with higher degree of unsaturation in sn-2 position are preferred, excluding arachidonic acid, overview
-
-
-
additional information
?
-
-
AgkTx-II exerts a potent antibacterial activity against Staphylococcus aureus, Proteus vulgaris, Proteus mirabilis, and Burkholderia pseudomallei. The MIC values of AgkTx-II range between 0.085 and 0.00276 mM. AgkTx-II exhibits no hemolytic action even at high doses in human erythrocytes. AgkTx-II treated mice show severe neurotoxicity, whereas in the skin, no alterations of skin myotoxicity are observed, overview
-
-
-
additional information
?
-
-
bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity
-
-
-
additional information
?
-
-
cPLA2alpha interacts with the cPLA2alpha-binding protein p11 via the hydroxyl group of Ser727, binding as annexin A2 complex, mechanism of regulation of group IVA phospholipase A2 activity by Ser727 phosphorylation, surface plasmon resonance analysis, overview
-
-
-
additional information
?
-
-
cPLA2alpha is regulated by phosphorylation at Ser505 and calcium-induced translocation to membranes
-
-
-
additional information
?
-
-
Cr-IV 1 shows a rapid cytolytic effect on mouse skeletal muscle myoblasts and myotubes in culture. Cr-IV 1 induces myonecrosis and edema upon intramuscular and intravenous injections, respectively, in mice
-
-
-
additional information
?
-
-, P24027
crotoxin is a heterodimeric molecular complex related to important envenomation effects, as neurological disorders, myotoxicity, and renal failure
-
-
-
additional information
?
-
-
cytosolic phospholipase A2 releases arachidonic acid metabolites from membrane phospholipids, reactive oxygen species are generated from arachidonic acid metabolites by ROS-producing enzymes, e.g. NADPH oxidase. Cyclooxgenase transforms arachidonic acid into prostaglandin H2, the immediate precursor of a variety of prostanoids including prostaglandin and thromboxane A, metabolism, overview
-
-
-
additional information
?
-
-
increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression, the effects are associated with increased interleukin-1beta and prostaglandin E2 in the serum and brain, overview
-
-
-
additional information
?
-
-, P00598
native and mutated PLA2s induce apoptotic death of U937 cells
-
-
-
additional information
?
-
-
peroxiredoxin 6 is a bifunctional protein with both GSH peroxidase and phospholipase A2 activities, and is responsible for the metabolism of lung surfactant phospholipids. Prdx6 has a major role in degradation of internalized dipalmitoyl phosphatidylcholine as well as in the remodeling of PC through the deacylation-reacylation pathway by lung granular pneumocytes, i.e. alveolar epithelial type II cells. Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
peroxiredoxin 6 is a bifunctional protein with both GSH peroxidase and phospholipase A2 activities, and is responsible for the metabolism of lung surfactant phospholipids. Prdx6 has a major role in degradation of internalized dipalmitoyl phosphatidylcholine as well as in the remodeling of PC through the deacylation-reacylation pathway by lung granular pneumocytes, i.e. alveolar epithelial type II cells. Mitrogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
phospholipase A2 hydrolyzes phospholipids at the sn-2 position to cleave the fatty-acid ester bond of L-glycerophospholipids. The catalytic dyad, formed by residues Asp99 and His48, along with a nucleophilic water molecule is responsible for enzyme hydrolysis
-
-
-
additional information
?
-
-
phospholipases A2 catalyze hydrolysis of fatty acids from the sn-2 position of phospholipids
-
-
-
additional information
?
-
-
prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview
-
-
-
additional information
?
-
-
the ability of secretory phospholipase A2 to hydrolyze cell membranes is highly dependent on the physical properties of the membrane, overview
-
-
-
additional information
?
-
-
the enzyme in venom effectively inhibits A-type K+ currents in mice and cause alterations of channel gating characters, such as the shifts of steadystate activation and inactivation curves to hyperpolarization direction and changes of V1/2 and slope factor, the effects are independent of the enzymatic activity as phospholipase, overview
-
-
-
additional information
?
-
-
the enzyme shows myonecrotic activity in rat kidneys causing mild to moderate focal acute tubular necrosis in the convoluted proximal tubules, overview
-
-
-
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid
-
-
-
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid. GVIA iPLA2 is involved in cell proliferation, mediating cell growth, apoptosis and glucose-induced insulin secretion
-
-
-
additional information
?
-
-
the snake phospholipase A2 neurotoxins enter nerve terminals, bind specifically to mitochondria, and open their transition pores, overview. The action of SPANs is very specific for the presynaptic nerve terminals in vivo
-
-
-
additional information
?
-
P84776, -
zhaoermiatoxin is highly myotoxic and displays high myonecrotic and edema activities
-
-
-
additional information
?
-
-
AdPLA is most likely a His-Cys PLA2, His23 and Cys113 are critical for activity of AdPLA, catalytic mechanism, overview. AdPLA has phospholipase activity but lacks acyltransferase activity
-
-
-
additional information
?
-
-
determination of the cytolytic activity od sPLA2 using oleate-labelled, autoclaved Escherichia coli cells as substrate, overview
-
-
-
additional information
?
-
-
fatty acyl-CoA is a substrate for GVIA iPLA2, The active site serine of the GVIA iPLA2 lies within a lipase consensus sequence Gly-X-Ser519-X-Gly. The group IVA PLA2 isozyme is specific for phospholipids containing arachidonic acid in the sn-2 position, substrate binding involving the C2 domain, the specific site in the C2 domain consists of Arg57, Lys58, and Arg59, structure, overview. The GVIA PLA2 contains multiple ankyrin repeats which may be important in mediating protein-protein interactions
-
-
-
additional information
?
-
P47712
inhibitor plus phospholipid vesicles cause a decreases at the C2 domain as well as charged residues on the putative membrane binding surface of the catalytic domain revealing the binding sites of the enzyme to the lipid surface, hypothetical model of initial membrane binding before lid opening, overview
-
-
-
additional information
?
-
-
interfacial binding and kinetics of cPLA2 and its phosphorylated forms in vitro, lipid vesicle formation, overview
-
-
-
additional information
?
-
-
molecular basis of phospholipase A2 activity toward phospholipids with sn-1 substitutions, molecular dynamics simulations, substrate binding structures comparisons with different compounds using the crystal structures of the enzymes from Apis mellifera and Homo sapiens, overview
-
-
-
additional information
?
-
P84776, -
PEG 400 molecule binding structure, determination and analysis, overview
-
-
-
additional information
?
-
-
Ser727 is not directly involved in either membrane binding or catalytic steps
-
-
-
additional information
?
-
-
sPLA2-IIA activity assays using the fluorescent probe ADIFAB, which consists of an acrylodan derivative of rat intestinal fatty acid binding protein that exhibits a shift in fluorescence upon binding to long-chain native fatty acids
-
-
-
additional information
?
-
-
the enzyme causes endema when applicated to the right footpad of male Swiss mice
-
-
-
additional information
?
-
-
the lysosomal isozyme PLA2 contains a Ser-His-Asp catalytic triad
-
-
-
additional information
?
-
-
the secretory isozyme has a catalytic dyad formed by Asp99 and His48
-
-
-
additional information
?
-
-
14C-oleate radio-labelled Escherichia coli membrane used as substrate
-
-
-
additional information
?
-
-
active splice forms of the enzyme GIVA-1 PLA2 and GIVA-2 PLA2 are composed of 7-8 ankyrin repeats, a linker region and a catalytic domain, uses a serine in the active site to catalyze the cleavage of the sn-2 ester bond
-
-
-
additional information
?
-
-
activity assayed using mixed micelles in a modified Dole assay
-
-
-
additional information
?
-
-
cPLA2 may release fatty acid hydroperoxides from membranes following denervation
-
-
-
additional information
?
-
-
does not hydrolyze either fibrinogen or thrombin
-
-
-
additional information
?
-
-
group IA enzyme appears to bind lipid substrate in the active site through the hydrophobic residues lining the active site channel, and binds neutral membrane substrate through interactions with a group of hydrophobic residues on the lipid binding surface of the molecule
-
-
-
additional information
?
-
-
phosphorylation at Ser505 is key for enzyme activity and lipid droplets formation
-
-
-
additional information
?
-
-
PLA2 shows low enzymatic activity toward positively charged vesicles due to a long lag period. PLA2 demonstrates a high degree of enzymatic activity toward negatively charged 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine and 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine/1,2-dioleoyl-sn-glycero-3-phosphatidylserine vesicles. Vesicle size distribution of zwitterionic 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine changes faster than that of 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine/1,2-dioleoyl-sn-glycero-3-phosphatidylserine 90:10
-
-
-
additional information
?
-
-
production of lysophosphatidylcholine
-
-
-
additional information
?
-
-
similar activity to phospholipids with different fatty acids in the sn-2 position, but with different preferences for the charge on the lipid surface
-
-
-
additional information
?
-
-
unilamellar liposomes composed of a 9:1 M ratio of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol, release of fatty acid
-
-
-
additional information
?
-
-
acidic PLA2 non-inhibits the factor Xa in a non-enzymatic mechanism
-
-
-
additional information
?
-
-
isoform cPLA2beta shows no activity with 1-palmitoyl-2-oleoyl-phosphatidylcholine
-
-
-
additional information
?
-
-
isoform cPLA2gamma shows no activity with 1-palmitoyl-2-oleoyl-phosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine, 1-palmitoyl-2-oleoyl-phosphatidylglycerol, and 1-palmitoyl-2-oleoyl-phosphatidylinositol
-
-
-
additional information
?
-
-
the enzyme does not show any proteolytic, ATPase and AchEase activity at a dose of 750 mM
-
-
-
additional information
?
-
-
the enzyme has hemolytic activity
-
-
-
additional information
?
-
Pseudomonas aeruginosa PAK-VL1
-
exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
infection by ExoU-producing Pseudomonas aeruginosa induces a rapid release of arachidonic acid as well as a significant release of prostaglandins PGE2 and PGI2 from human endothelial cells of the HMEC-1 line, overview, ExoU may contribute to Pseudomonas aeruginosa pathogenesis by inducing an eicosanoid-mediated inflammatory response of host organisms, overview
-
-
-
additional information
additional information
-
A7LGL2, -
-
Bacillus megaterium 216 produces the bacteriocin megacin A-216, which leads to lysis of the producer cell and kills Bacillus megaterium and a few other bacterial species.
-
-
additional information
additional information
-
Bacillus megaterium 216
A7LGL2
-
Bacillus megaterium 216 produces the bacteriocin megacin A-216, which leads to lysis of the producer cell and kills Bacillus megaterium and a few other bacterial species.
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1,2-diacyl-sn-glycero-3-phosphatide + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-diacyl-sn-glycero-3-phosphatide + H2O
?
show the reaction diagram
-
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1-oleoylglycerophosphocholine + oleic acid
show the reaction diagram
-
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoylglycerophosphocholine + palmitic acid
show the reaction diagram
-
-
-
-
?
1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O
1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
show the reaction diagram
Q13093
i.e. platelet-activating factor
-
-
?
1-oleoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
1-palmitoyl-sn-glycero-3-phosphocholine + H2O
?
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
O96100
-
-
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + a carboxylate
show the reaction diagram
-
the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview
-
-
?
phospholipid + H2O
lysophospholipid + fatty acid
show the reaction diagram
P47713
the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
P00592
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
-
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
myotoxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
presynaptic neurotoxicity of neutral PLA2
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
aldosterone-dependent sodium transport
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac toxicity
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac contraction and excitation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
cardiac contraction and excitation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
hemolytic activity of basic PLA2
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
signal transduction
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
eicosanoids
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
O60733
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
phospholipids + H2O
?
show the reaction diagram
-
allergenic
-
-
-
phospholipids + H2O
?
show the reaction diagram
-
cancer
-
-
?
plasmalogen + H2O
?
show the reaction diagram
-
-
-
-
?
platelet activating factor + H2O
?
show the reaction diagram
-
-
-
-
?
platelet activating factor + H2O
?
show the reaction diagram
-
hGX sPLA2 hydrolyzes platelet activating factor, which is a reaction catalyzed by the platelet activating factor-acetylhydrolase, EC 3.1.1.47
-
-
?
soya lecithin + H2O
?
show the reaction diagram
P59071
-
-
-
?
diheptanoyl phosphatidylcholine + H2O
1-heptanoyl-sn-glycerophosphocholine + heptanoic acid
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
anticoagulant and haemolytic activity
-
?
additional information
?
-
-
damages membranes by a noncatalytic Ca2+-independent mechanism
-
?
additional information
?
-
-
enzyme causes myotoxicity but no significant neurotoxicity
-
?
additional information
?
-
-
enzyme has cytotoxic activity and can lyse erythrocytes
-
?
additional information
?
-
-
enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells
-
?
additional information
?
-
-, Q8JIY9
induces edema, has haemolytic activity and inhibits ADP-induced rabbit platelet aggregation
-
?
additional information
?
-
-
induces pharmacological effects, including myotoxic or anticoagulant effects, and insulin secretion stimulating effects through a non-enzymatic mechanism
-
?
additional information
?
-
-
inhibits platelet aggregation induced by collagen and ADP
-
?
additional information
?
-
-
involved in mast cell degranulation, creatinine kinase release, causes edema and myonecrosis, edema induction is not dependent on the catalytic activity if the enzyme
-
?
additional information
?
-
-
involved in synaptic plasticity, generation of second messengers, axon regeneration and neurodegeneration
-
?
additional information
?
-
-
role in mediating fatty acid release from intact cells
-
?
additional information
?
-
-
role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface
-
?
additional information
?
-
-
role in the release of linolenic acid
-
?
additional information
?
-
-
SIIISPIIA, SIIISPIIB and SIIISPIIIA show significant anticoagulant activity but no indirect haemolytic activity. SIIISPIIIB shows no anticoagulant activity but presents indirect haemolytic activity. With the exception of SIIISPIIB, which inhibits platelet aggregation, all the others are capable of inducing edema
-
?
additional information
?
-
-
stimulates CD11b translocation from the PMN granule store to the plasma membrane and enhances neutrophil motility on collagen-coated surfaces, first causes a non-enzymatic stimulation of PMN leading to the activation of cytosolic PMN PLA2 production and of arachidonate metabolites involved in stimulation of PMN degranulation and motility
-
?
additional information
?
-
-
stimulates CD11b translocation from the polymorph nuclear granule store to the plasma membrane and enhances neutrophil motility on collagen-coated surfaces, first causes a non-enzymatic stimulation of PMN leading to the activation of cytosolic PMN PLA2 production and of arachidonate metabolites involved in stimulation of PMN degranulation and motility
-
?
additional information
?
-
-
ExoU is a potent phospholipase virulence factor that is translocated into the cytosol by type III secretion system
-
-
-
additional information
?
-
-
both isoenzymes NK-PLA2-I and NK-PLA2-II cause significantly more damage to mitochondrial membranes as compared to erythrocyte membranes
-
-
-
additional information
?
-
-
despite all features of a class II phospholipase A2, enzyme does not show phospholipase and hemorrhagic activity, but weak toxic and anticoagulant activity
-
-
-
additional information
?
-
-
enzyme causes a significant concentration-dependent neuromuscular blockade in the chick biventer cervicis preparation
-
-
-
additional information
?
-
-
enzyme extracts cause vacuolating and cytolytic effects on Chinese hamster ovary cells in tissue culture
-
-
-
additional information
?
-
-
enzyme has hemolytic activity with red blood cells, which is greatly inhibited by phosphatidylcholines
-
-
-
additional information
?
-
-
enzyme induces hemolysis when incubated with exogenous lecithin
-
-
-
additional information
?
-
-
enzyme inhibits platelet aggregation which is induced by 1 mmol/l ADP, with IC50 of 6 mmol/l
-
-
-
additional information
?
-
-
enzyme is a class B1 platelet aggregation inhibitor and inhibits platelet aggregation induced by ADP, collagen and epinephrine
-
-
-
additional information
?
-
-
enzyme is toxic to mice with a LD50 value of 0.098 mg/kg body weight, producing acute neurotoxic symptoms. It is weakly coagulant and devoid of cytotoxicity, myotoxicity, hemorrhage, edema inducing, and direct lytic activities
-
-
-
additional information
?
-
Micrurus dumerilii carinicauda
-
enzyme produces neuromuscular blockade in vertebrate nerve-muscle preparations without involving cholinergic nicotinic receptors
-
-
-
additional information
?
-
-
enzymes show post-synaptic neurotoxicity, they are toxic to mice with LD50 of 1.9-2.1 mg/kg body weight
-
-
-
additional information
?
-
P24605
BaTX induces myonecrosis and edema in vivo in mice upon intramuscular or subcutaneous injection, respectively, in vitro, the enzyme rapidly lysed skeletal muscle myoblasts, and causes a potent blockade of neuromuscular transmission in young chicken biventer cervicis preparations, overview
-
-
-
additional information
?
-
-
bile salt regulation of lipid metabolism via both activation and inhibition of PLA2, interaction and binding structure analysis, overview
-
-
-
additional information
?
-
-
crotoxin, a potent neurotoxin from the venom of the Brazilian rattlesnake, exists as a heterodimer formed between a phospholipase A2 and a catalytically inactive acidic phospholipase A2 analogue crotapotin, overview
-
-
-
additional information
?
-
-, P20474
CTX shows myotoxic and neurotoxic activity requiring calcineurin, overview
-
-
-
additional information
?
-
-
during apoptosis, changes occur in lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A2, mechanism, the membranes of apoptotic cells become susceptible to sPLA2 through a reduction in lipid-neighbor interactions that facilitates migration of phospholipids into the enzyme active site, overview
-
-
-
additional information
?
-
-
exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
infection by ExoU-producing Pseudomonas aeruginosa induces a rapid release of arachidonic acid as well as a significant release of prostaglandins PGE2 and PGI2 from human endothelial cells of the HMEC-1 line, overview, ExoU may contribute to Pseudomonas aeruginosa pathogenesis by inducing an eicosanoid-mediated inflammatory response of host organisms, overview
-
-
-
additional information
?
-
Q8QG87
isozymes BinTx-I and BinTx-II show myotoxic activity in mice skeletal muscle and contribute to the neuromuscular activity of venom, overview
-
-
-
additional information
?
-
-
PLA2s affect cellular activation, signal transduction, and possibly innate immunity, the specific secretory isozyme sPLA2-X neutralizes human immunodeficiency virus type 1 through degradation of the viral membrane, the catalytic function is required for antiviral activity, the target cells of infection are unaffected, sPLA2-X potently reduces gene transfer of HIV-1 Env-pseudo-typed lentivirus vectors and inhibits the replication of both CCR5- and CXCR4-tropic HIV-1 in human CD4 T cells. Virions resistant to damage by antibody and complement were sensitive to lysis by sPLA2-X, mechanism, overview
-
-
-
additional information
?
-
-
Pseudomonas aeruginosa PLA2 is involved in induction of polymorphonuclear cell migration across lung epithelial barriers in hosts, e.g. A549 alveolar epithelial cells, mediated by epithelial production of the eicosanoid hepoxilin A3, HXA3, in response to Pseudomonas aeruginosa infection, HXA3 is a polymorphonuclear cell, PMN, chemoattractant metabolized from arachidonic acid, overview
-
-
-
additional information
?
-
-
the enzyme is a component of the venom and causes cytotoxic lesions in murine skeletal muscle C2C12 myoblasts and myotubes, overview
-
-
-
additional information
?
-
-
the isozymes are neurotoxic and lethal, with the acidic isozyme DrK-aI being the most active toxin, overview
-
-
-
additional information
?
-
Q13093
the lipoprotein-associated PLA2 plays a crucial role in atherosclerosis, and is proposed as a promising target for drug discovery
-
-
-
additional information
?
-
-
the PLA2, i.e. RVV-7, is the basic toxin of Russell’s viper venom, it shows cytotoxic activity with B16F10 melanoma cells, it inhibits trypsin, but not chymotrypsin or bromelain, overview
-
-
-
additional information
?
-
P84776, -
zhaoermiatoxin induces oedema and strong myonecrosis without detectable PLA2 catalytic activity, overview
-
-
-
additional information
?
-
-
AgkTx-II exerts a potent antibacterial activity against Staphylococcus aureus, Proteus vulgaris, Proteus mirabilis, and Burkholderia pseudomallei. The MIC values of AgkTx-II range between 0.085 and 0.00276 mM. AgkTx-II exhibits no hemolytic action even at high doses in human erythrocytes. AgkTx-II treated mice show severe neurotoxicity, whereas in the skin, no alterations of skin myotoxicity are observed, overview
-
-
-
additional information
?
-
-
bile acids are likely to contribute to lung injury, causing surfactant inactivation through the increased sPLA2 activity
-
-
-
additional information
?
-
-
cPLA2alpha interacts with the cPLA2alpha-binding protein p11 via the hydroxyl group of Ser727, binding as annexin A2 complex, mechanism of regulation of group IVA phospholipase A2 activity by Ser727 phosphorylation, surface plasmon resonance analysis, overview
-
-
-
additional information
?
-
-
cPLA2alpha is regulated by phosphorylation at Ser505 and calcium-induced translocation to membranes
-
-
-
additional information
?
-
-
Cr-IV 1 shows a rapid cytolytic effect on mouse skeletal muscle myoblasts and myotubes in culture. Cr-IV 1 induces myonecrosis and edema upon intramuscular and intravenous injections, respectively, in mice
-
-
-
additional information
?
-
-, P24027
crotoxin is a heterodimeric molecular complex related to important envenomation effects, as neurological disorders, myotoxicity, and renal failure
-
-
-
additional information
?
-
-
cytosolic phospholipase A2 releases arachidonic acid metabolites from membrane phospholipids, reactive oxygen species are generated from arachidonic acid metabolites by ROS-producing enzymes, e.g. NADPH oxidase. Cyclooxgenase transforms arachidonic acid into prostaglandin H2, the immediate precursor of a variety of prostanoids including prostaglandin and thromboxane A, metabolism, overview
-
-
-
additional information
?
-
-
increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression, the effects are associated with increased interleukin-1beta and prostaglandin E2 in the serum and brain, overview
-
-
-
additional information
?
-
-, P00598
native and mutated PLA2s induce apoptotic death of U937 cells
-
-
-
additional information
?
-
-
peroxiredoxin 6 is a bifunctional protein with both GSH peroxidase and phospholipase A2 activities, and is responsible for the metabolism of lung surfactant phospholipids. Prdx6 has a major role in degradation of internalized dipalmitoyl phosphatidylcholine as well as in the remodeling of PC through the deacylation-reacylation pathway by lung granular pneumocytes, i.e. alveolar epithelial type II cells. Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
peroxiredoxin 6 is a bifunctional protein with both GSH peroxidase and phospholipase A2 activities, and is responsible for the metabolism of lung surfactant phospholipids. Prdx6 has a major role in degradation of internalized dipalmitoyl phosphatidylcholine as well as in the remodeling of PC through the deacylation-reacylation pathway by lung granular pneumocytes, i.e. alveolar epithelial type II cells. Mitrogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity, overview
-
-
-
additional information
?
-
-
phospholipase A2 hydrolyzes phospholipids at the sn-2 position to cleave the fatty-acid ester bond of L-glycerophospholipids. The catalytic dyad, formed by residues Asp99 and His48, along with a nucleophilic water molecule is responsible for enzyme hydrolysis
-
-
-
additional information
?
-
-
phospholipases A2 catalyze hydrolysis of fatty acids from the sn-2 position of phospholipids
-
-
-
additional information
?
-
-
prion infection greatly increased both the phosphorylation of cPLA2 and prostaglandin E2 production, the alternatively folded prion protein PrPSc causes a dose-dependent increase in the free cholesterol concentration of cortical neurons, overview
-
-
-
additional information
?
-
-
the ability of secretory phospholipase A2 to hydrolyze cell membranes is highly dependent on the physical properties of the membrane, overview
-
-
-
additional information
?
-
-
the enzyme in venom effectively inhibits A-type K+ currents in mice and cause alterations of channel gating characters, such as the shifts of steadystate activation and inactivation curves to hyperpolarization direction and changes of V1/2 and slope factor, the effects are independent of the enzymatic activity as phospholipase, overview
-
-
-
additional information
?
-
-
the enzyme shows myonecrotic activity in rat kidneys causing mild to moderate focal acute tubular necrosis in the convoluted proximal tubules, overview
-
-
-
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid
-
-
-
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid. GVIA iPLA2 is involved in cell proliferation, mediating cell growth, apoptosis and glucose-induced insulin secretion
-
-
-
additional information
?
-
-
the snake phospholipase A2 neurotoxins enter nerve terminals, bind specifically to mitochondria, and open their transition pores, overview. The action of SPANs is very specific for the presynaptic nerve terminals in vivo
-
-
-
additional information
?
-
P84776, -
zhaoermiatoxin is highly myotoxic and displays high myonecrotic and edema activities
-
-
-
additional information
additional information
-
A7LGL2, -
-
Bacillus megaterium 216 produces the bacteriocin megacin A-216, which leads to lysis of the producer cell and kills Bacillus megaterium and a few other bacterial species.
-
-
additional information
?
-
Pseudomonas aeruginosa PAK-VL1
-
exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview
-
-
-
additional information
additional information
-
Bacillus megaterium 216
A7LGL2
-
Bacillus megaterium 216 produces the bacteriocin megacin A-216, which leads to lysis of the producer cell and kills Bacillus megaterium and a few other bacterial species.
-
-
additional information
?
-
-
infection by ExoU-producing Pseudomonas aeruginosa induces a rapid release of arachidonic acid as well as a significant release of prostaglandins PGE2 and PGI2 from human endothelial cells of the HMEC-1 line, overview, ExoU may contribute to Pseudomonas aeruginosa pathogenesis by inducing an eicosanoid-mediated inflammatory response of host organisms, overview
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
ExoU lacks detectable phospholipase or esterase activity in vitro, experiments in vivo demonstrate significant phospholipase activity, indicating that one or more host cell factors are required for activation of ExoU
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ba2+
-
can replace Ca2+ but enzyme shows decreased activity
Ba2+
-
diminishes susceptibility to trypsin attack; prevents p-bromophenacyl bromide inactivation
Ba2+
-
prevents p-bromophenacyl bromide inactivation
Ca2+
-
structure of Ca2+-binding site
Ca2+
-
-
Ca2+
-
Ca2+-dependent PLA2-association with cellular membranes at a concentration of 300-500 nM
Ca2+
-
Ca2+-dependent association with cellular membranes
Ca2+
-
PLA2-binding is Ca2+-independent, PLA2-activation requires Ca2+
Ca2+
-
two Ca2+ binding sites, first Ca2+ is strongly bound and essential for enzyme activity, the second binds more weakly and improves the enzymes affinity for lipid-water interfaces
Ca2+
-
two Ca2+ binding sites, first Ca2+ is strongly bound and essential for enzyme activity, the second binds more weakly and stabilizes interaction of two enzymes in crystal structure
Ca2+
-
-
Ca2+
-
two Ca2+ binding sites, first Ca2+ is strongly bound and essential for enzyme activity, the second binds more weakly and improves the enzymes affinity for lipid-water interfaces
Ca2+
-
prevents p-bromophenacyl bromide inactivation
Ca2+
-
Ca2+ required for crystallisation
Ca2+
-
diminishes susceptibility to trypsin attack; only one Ca2+-binding site; prevents p-bromophenacyl bromide inactivation
Ca2+
-
prevents p-bromophenacyl bromide inactivation
Ca2+
-
2 adjacent Ca2+-binding sites
Ca2+
P14418
-
Ca2+
-
increases activity by 125% at 1 mM
Ca2+
-
dependent
Ca2+
P00630
dependent
Ca2+
-
requirement, optimal concentration: 7 mM
Ca2+
-
activation above 1 mM
Ca2+
Q9M0D7
requirement, optimal concentration: 10 mM
Ca2+
-
dependent
Ca2+
O77793
dependent
Ca2+
-
requirement, optimal concentration: 10 mM
Ca2+
-
requirement, optimal concentration: 10 mM
Ca2+
-
requirement, optimal concentration: 2-40 mM
Ca2+
-
dependent
Ca2+
-
requirement, isoform PLA2-L
Ca2+
-
requirement
Ca2+
-, Q8JIY9
dependent
Ca2+
-
required
Ca2+
-
activating above 1 mM
Ca2+
Q5CCT8
required
Ca2+
Trimorphodon biscutatus lambda
-
-
Ca2+
Q6T179
-
Ca2+
-
required
Ca2+
-
activates maximally at 7 mM CaCl2
Ca2+
P47713
required
Ca2+
-, P47712
;
Ca2+
-
activates
Ca2+
O96100
required at 1 mM or above by the wild-type and mutant enzyme
Ca2+
-
absolutely requird for the PLA2 activity of RVV-7
Ca2+
-
required for activity
Ca2+
-
required at 10 mM for full activity
Ca2+
-
residue Asp49 in the calcium-binding loop is essential for controlling binding of the calcium ion and catalytic action of phospholipase A2
Ca2+
-
dependent on
Ca2+
-
the secretory isozyme is Ca2+-dependent
Ca2+
-
the adipose-specific phospholipase A2 is activated by Ca2+, but it is not essential for activity
Ca2+
-
required
Ca2+
-
required
Ca2+
-
calcium, phosphorylation at Ser505 and the putative phosphatidylinositol 4,5-bisphosphate binding site regulate translocation and arachidonic acid release, overview. Influx of extracellular calcium is essential for stable binding of cPLA2alpha to Golgi and arachidonic acid release. phosphatidylinositol 4,5-bisphosphate improves Ca2+ binding by about 2fold
Ca2+
-
soluble PLA2 shows Ca+2-dependent and independent fractions, corresponding to 3% or 68% of total activity, respectively
Ca2+
-
does only slightly alter the effects of the enzyme on K+ currents, overview
Ca2+
P24027
dependent on
Ca2+
-, P00598
required
Ca2+
P84776
binding site structure analysis, overview
Ca2+
-
specific activity increases to reach its maximum in the presence of 10 mM Ca2+ using phosphatidylcholine as substrate
Ca2+
-
is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant PLA2 activity
Ca2+
-
is required for catalytic activity. With increase in the concentration of calcium, increase of recombinant sPLA2 activity
Ca2+
-
essential for both catalysis and enzyme binding to the substrate. The catalytic Ca2+ may be coordinated in a tetrahedral environment formed by the oxygen atoms of Tyr28, Gly30, Gly32 and Asp49. Second Ca2+-binding site is conserved and is formed by four residues: Glu71, Ile72, Asn89, and Glu92. Optimal Ca2+ concentration is about 4 mM
Ca2+
-
essential for catalysis and substrate binding
Ca2+
-
required for catalysis
Ca2+
-, Q9XG81
Ca2+-binding loop
Ca2+
P15445
Ca2+ is coordinated by the Asp48 carboxylate, two water molecules, and three polypeptide carbonyl oxygen atoms of the Ca2+-binding loop
Ca2+
-
required for catalysis
Ca2+
-
free Ca2+ is required for interaction between PLA2 and vesicles under catalytic conditions, Ca2+ addition for activation of PLA2 under initially noncatalytic conditions. Differences between enzymatic activity under initially catalytic and noncatalytic conditions, membrane binding under noncatalytic conditions must either cause PLA2 to adopt a less favorable conformation for enzymatic activity or prevent a Ca2+ ion (after Ca2+ addition) from entering the active site pocket
Ca2+
C6YBD6, -
dependent on
Ca2+
-
dependent on
Ca2+
-
shows Ca2+-dependent hydrolytic activity
Ca2+
-
required for catalysis, Scol/Pla contains Gly30 and Gly33, which may be sites for calcium binding
Ca2+
-
dependent on Ca2+, full activity at 10 mM
Ca2+
-
the enzyme activity increases with increase in Ca2+ concentration, the addition of Mg2+ with Ca2+ increases while the addition of Ba2+ with Ca2+ decreases the enzymatic activity
Ca2+
Q6T178
essential for activity
Ca2+
-
cytosolic isoform PLA2beta action on phosphatidylcholine vesicles displays a requirement for Ca2+ only in the presence of cardiolipin
Ca2+
C0LTQ2, -
stimulation of activity in the presence of 0.6 mM Ca2+
Cd2+
-
1% of the activity obtained with Ca2+
Cd2+
-
can replace Ca2+, decreased activity
Co2+
-
increases activity by 270% at 1 mM, 150% increase at 0.1 mM
Co2+
O96100
activates
Cu2+
-
at 10 mM, diminishes activation in presence of 1 mM Ca2+, slight activation in absence of Ca2+
K+
-
located in Ca2+-binding loop with sevenfold coordination
Mg2+
-
can replace Ca2+, decreased activity
Mg2+
-
can replace Ca2+, decreased activity
Mg2+
-
can replace Ca2+, decreased activity
Mg2+
-
10 mM, increases activity slightly in presence of 1 mM Ca2+
Mg2+
-
10 mM Mg2+ increases the activity slightly in the presence of 1 mM Ca2+
Mg2+
-
activates
Mg2+
O96100
activates
Mg2+
-
at 10 mM, diminishes activation in presence of 1 mM Ca2+, poor activation in absence of Ca2+
Mn2+
-
can replace Ca2+ but enzyme shows decreased activity
Mn2+
-
10 mM, increases activity slightly in presence of 1 mM Ca2+
Mn2+
-
10 mM Mn2+ increases the activity slightly in the presence of 1 mM Ca2+
Mn2+
-
activates
sodium taurodeoxycholate
-
activates
Sr2+
-
1% of the activity obtained with Ca2+
Sr2+
-
can replace Ca2+, decreased activity
Sr2+
-
diminishes susceptibility to trypsin attack and prevents p-bromophenacyl bromide inactivation
Zn2+
Q6T179
one mole per mole of subunit, one Zn2+ is situated at the interface of the heterodimer, the second is on the surface of subunit Cys-PLA2
Mn2+
-
activates at 10 mM in presence of 1 mM Ca2+
additional information
-
no requirement for Ca2+, isoform cPLA2-alpha
additional information
-
no requirement for Ca2+
additional information
-
no requirement for Ca2+
additional information
-
independence of Ca2+
additional information
P45881
the enzyme is Ca2+-independent
additional information
-
Ca2+ independent PLA2, iPLA2s, includes six different types GVIA, GVIB, GVIC, GVID, GVIE, and GVIF PLA2
additional information
-
Ca2+ independent PLA2, iPLA2s, includes three different types GVIA, GVIB, and GVIC PLA2
additional information
-
the enzyme is Ca2+-independent
additional information
-
GIVA PLA2 does not require Ca2+ for catalytic activity
additional information
-
not dependent upon Ca2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(+-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecyl-1-O-triphenylmethylglycerol
-
-
(2-(2-amino-2-oxoethyl)-5-propyl-1H-indol-7-yl)acetic acid
P59071
-
(2-(4-((3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)phenyl)-1,3-oxazol-4-yl)acetic acid
-
-
(2E,4E,6S)-6-[(2-oxohexadecanoyl)amino]deca-2,4-dienoic acid
-
reduces the cellular release of arachidonic acid by 6%
(2E,4S)-4-[(2-oxohexadecanoyl)amino]oct-2-enoic acid
-
reduces the cellular release of arachidonic acid by 74%
(3-aminooxalyl-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yl)oxyacetic acid methyl ester
-
LY374388, potent sPLA2 inhibitor
(3E)-3-[(3aS,7aS)-3-methyl-2-oxo-6-(propan-2-ylidene)hexahydro-1-benzofuran-7(4H)-ylidene]propanoic acid
-
non-competitive inhibition
(3R,3aS,5aS,8bR)-3,5a,5b-trimethyl-3a,4,5,5a,5b,8b-hexahydro-2H-cyclopenta[2,3]cyclopropa[1,2-g]benzofuran-2,6(3H)-dione
-
non-competitive inhibition
(3R,3aS,5aS,9bR)-3,5a,9-trimethyl-3a,4,5,5a-tetrahydronaphtho[1,2-b]furan-2,8(3H,9bH)-dione
-
non-competitive inhibition
(3R,3aS,6R,8S,9bS)-6,8-dihydroxy-3,6,9-trimethyl-3,3a,4,5,6,6a,7,8-octahydroazuleno[4,5-b]furan-2(9bH)-one
-
non-competitive inhibition
(3R,3aS,6R,8S,9bS)-8-hydroxy-3,6,9-trimethyl-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate
-
-
(3R,3aS,6R,9bS)-3,6,9-trimethyl-2,8-dioxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-6-yl acetate
-
-
(3R,3aS,6R,9bS)-6-hydroxy-3,6,9-trimethyl-3a,4,5,6,6a,7-hexahydroazuleno[4,5-b]furan-2,8(3H,9bH)-dione
-
-
(3S)-4-[(4-benzylphenyl)sulfanyl]-3-[(7-phenylheptanoyl)amino]butane-1-sulfonic acid
-
bioisosteric replacements, binding energy of -22.05 kJ/mol
(3S)-4-[(4-benzylphenyl)sulfanyl]-3-[(7-phenylheptanoyl)amino]butyl phosphonic acid
-
bioisosteric replacements, binding energy of -19.76 kJ/mol
(3S)-4-[(4-benzylphenyl)sulfanyl]-3-[[7-(4-hydroxyphenyl)heptanoyl]amino]butane-1-sulfonic acid
-
bioisosteric replacements, molecular structure is characterized by a chiral centre of absolute (R)-configuration, four carbons in the R1 chain, a hydroxyl group as a substituent in the para-position of the phenyl ring in R1 chain and a sulphonate group instead of the carboxylate group, indicates the highest binding energy (-29.1 kJ/mol) than all the other analogues and the prototype
(3S)-5a-(1-bromo-1-methylethyl)-3-methyl-3,3a,5,5a,8,9b-hexahydro-4H-furo[2,3-f]chromene-2,7-dione
-
non-competitive inhibition
-
(4-((3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)phenoxy)acetic acid
-
-
(4-((3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)phenyl)acetic acid
-
-
(4-((6-bromo-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)phenyl)acetic acid
-
-
(4R)-5-[(4-benzylphenyl)sulfanyl]-4-[(7-phenylheptanoyl)amino]pentanoic acid
-
(R)-configuration of FPL67047XX, binding energy of -19.5 kJ/mol
(4R)-6-methyl-4-[(2-oxohexadecanoyl)amino]heptanoic acid
-
reduces the cellular release of arachidonic acid by 62%
(4S)-4-[(2-oxododecanoyl)amino]octanoic acid
-
reduces the cellular release of arachidonic acid by 56%
(4S)-4-[(2-oxohexadecanoyl)amino]nonanoic acid
-
-
(4S)-4-[(2-oxohexadecanoyl)amino]octanoic acid
-
reduces the cellular release of arachidonic acid by 79%
(4S)-5-[(4-benzylphenyl)sulfanyl]-4-[(5-phenylpentanoyl)amino]pentanoic acid
-
decreased carbon chain length between the amide group and the aromatic ring of the R1 chain, binding energy of -22.02 kJ/mol
(4S)-5-[(4-benzylphenyl)sulfanyl]-4-[[7-(4-hydroxyphenyl)heptanoyl]amino]pentanoic acid
-
substituents in the para-position of the aromatic ring R1, higher binding energy (-27.61 kJ/mol) than the prototype and all the other analogues except structure 9
(4S)-5-[(4-benzylphenyl)sulfanyl]-4-[[7-(4-methoxyphenyl)heptanoyl]amino]pentanoic acid
-
substituents in the para-position of the aromatic ring R1, binding energy of -22.23 kJ/mol
(4S)-5-[(4-benzylphenyl)sulfanyl]-4-[[7-(4-nitrophenyl)heptanoyl]amino]pentanoic acid
-
substituents in the para-position of the aromatic ring R1, binding energy of -20.25 kJ/mol
(5S)-5-[(2-oxohexadecanoyl)amino]decanoic acid
-
-
(5S)-5-[(2-oxohexadecanoyl)amino]nonanoic acid
-
reduces the cellular release of arachidonic acid by 59%
(6E)-6-(bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one
-
i.e. BEL, bromoenol lactone suicide inhibitor, alkylates Cys-residues
(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
arachidonic acid with the COOH group replaced by COCF3, i.e. AACOCF3
(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
-
-
(9Z)-9-(hydroxyimino)-9H-fluorene-4-carboxamide
-
inhibition of phospholipase A2 activity of cytotoxin ExoU
(E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one
-
-
(R)-4-(7-phenylheptanamido)octanoic acid
-
-
(R)-gamma-norleucine
-
a highly selective inhibitor of isozyme GV sPLA2
(R)-methyl 6-methyl-4-(2-oxohexadecanamido)heptanoate
-
-
(S)-2-(2-(2-oxohexadecanamido)hexanamido)acetic acid
-
contains a free carboxyl group, inhibits GIVA cPLA2 without affecting the activity of the other intracellular enzyme GVIA iPLA2
(S)-2-(2-(2-oxohexadecanamido)hexyloxy)acetic acid
-
selectively inhibits GIVA cPLA2, due to its free carboxyl group. Most potent inhibitor of GIVA cPLA2. Reduces the cellular release of arachidonic acid by 68%
(S)-2-(3-methyl-2-(2-oxohexadecanamido)butanamido)acetic acid
-
contains a free carboxyl group, inhibits GIVA cPLA2 without affecting the activity of the other intracellular enzyme GVIA iPLA2
(S)-ethyl 2-(2-(2-oxohexadecanamido)hexanamido)acetate
-
ethyl ester based on Nle-Gly dipeptide, potent inhibition of GVIA iPLA2, inhibits GIVA cPLA2 (73%) and GV sPLA2 (63%)
(S)-ethyl 2-(2-(2-oxohexadecanamido)hexyloxy)acetate
-
preferentially inhibits GVIA iPLA2, is a potent inhibitor of GVIA iPLA2, inhibits GIVA cPLA2 by 52% and GV sPLA2 by 81%
(S)-ethyl 6-(2-oxohexadecanamido)decanoate
-
-
(S)-methyl 2-(2-(2-oxohexadecanamido)hexanamido)acetate
-
methyl ester based on dipeptide Nle-Gly, inhibits both GIVA cPLA2 and GVIA iPLA2, showing a small preference for GIVA cPLA2, inhibits GV sPLA2 by 65%
(S)-methyl 2-(3-methyl-2-(2-oxohexadecanamido)butanamido)acetate
-
methyl ester based on dipeptide Val-Gly, inhibits activity of GIVA cPLA2 by 25%
(S)-methyl 4-(2-oxohexadecanamido)octanoate
-
-
(S)-methyl 4-(7-phenylheptanamido)octanoate
-
-
(S)-tert-butyl 2-(2-(2-oxohexadecanamido)hexanamido)acetate
-
tert-butyl ester based on Nle-Gly dipeptide, potent inhibition of GVIA iPLA2, inhibits GIVA cPLA2 (72%) and GV sPLA2 (59%)
(S)-tert-butyl 2-(2-(2-oxohexadecanamido)hexyloxy)acetate
-
preferentially inhibits GVIA iPLA2 (81% inhibition), inhibits GIVA cPLA2 by 44% and GV sPLA2 by 57%
(S)-tert-butyl 2-(3-methyl-2-(2-oxohexadecanamido)butanamido)acetate
-
tert-butyl ester based on dipeptide Val-Gly, inhibits both GIVA cPLA2 and GVIA iPLA2, showing a small preference for GIVA cPLA2, reduces GV sPLA2 activity by 78%. Reduces the cellular release of arachidonic acid by 30%
(S)-tert-butyl 4-(2-oxohexadecanamido)pentanoate
-
-
(S,2E,4E)-6-(2-oxohexadecanamido)deca-2,4-dienoic acid
-
-
(S,2E,4E)-ethyl 6-(2-oxohexadecanamido)deca-2,4-dienoate
-
-
([1-[amino(oxo)acetyl]-3-(biphenyl-2-ylmethyl)-2-(2-methylpropyl)indolizin-8-yl]oxy)acetic acid
-
-
([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)acetic acid
-
-
1,1,1,2,2-pentafluoro-5-(4-hexyloxy-phenyl)-pentan-3-one
-
-
1,1,1,2,2-pentafluoro-7-phenyl-heptan-3-one
-
a selective inhibitor of GVIA iPLA2
1,1,1,2,2-pentafluoro-8-phenyl-octan-3-one
-
-
1,1,1,2,2-pentafluoro-9-phenyl-nonan-3-one
-
-
1,1,1,2,2-pentafluoro-octadecan-3-one
-
-
1,1,1,3,3-pentafluoro-6-phenyl-hexane-2,2-diol
-
-
1,1,1,3-tetrafluoro-heptadecan-2-one
-
-
1,1,1-trifluoro-4-(4-hexyloxy-phenyl)-butan-2-one
-
-
1,1,1-trifluoro-6-(4-hexyloxy-phenyl)-hexan-2-one
-
-
1,1,1-trifluoro-6-phenylhexan-2-one
-
-
1,1,1-trifluoro-7-phenylheptan-2-one
-
-
1,1,1-trifluoro-8-phenyloctan-2-one
-
-
1,1,1-trifluoroheptadecan-2-one
-
-
1,2-Didecanoin
-
inhibition below the normal cutoff pressure of PLA2
1,2-dipalmitoyl-phosphatidylcholine
-
large unilamellar vesicles, inhibits hydrolysis of 1,2-dipalmitoyl-phosphatidylcholine small unilamellar vesicles
1,3,5-trihydroxybenzene
-
potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview
1,3-dihydroxy benzene
-
potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview
1-(2-dimethylaminoethyl)-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-(4-carboxybenzyl)-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-(4-octylphenoxy)-3-[5-(1H-tetrazol-5-yl)indol-1-yl]propan-2-one
-
inhibits isozyme cPLA2alpha
1-(9H-fluoren-4-ylcarbonyl)piperidine
-
inhibition of phospholipase A2 activity of cytotoxin ExoU
1-(carboxymethyl)-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-(carboxypentyl)-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-(carboxypropyl)-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-benzyl-5-[3-(4-octylphenoxy)-2-oxopropoxy]-indole-2-carboxylic acid
-
-
1-bromo-2-octanone
-
-
1-H-indole-3-glyoxamide
-
varespladib methyl, potent sPLA2 inhibitor
1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol
P00592
i.e. MJ33
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
-
MJ33, competitive inhibitor
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
-
MJ33, competitive inhibitor
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
-
MJ33, competitive inhibitor
1-hexyl-5-[3-(4-octylphenoxy)-2-oxopropoxy]indole-2-carboxylic acid
-
-
1-methyl 5-[3-(4-octylphenoxy)-2-oxopropoxy]-indole-2-carboxylic acid
-
-
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
competitive inhibition of platelet activating factor hydrolysis
1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
-
competitive inhibitor toward sPLA2, dose-dependent inhibition
1-palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
-
competitive inhibitor toward recombinant sPLA2, dose-dependent inhibition
1-sn-phosphoglycerides
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-5-carboxylic acid
-
43% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is less than 1 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-6-carboxylic acid
-
44% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 2 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]-2,3-dihydro-1H-indole-5-carboxylic acid
-
-
1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-5-carboxylic acid
-
49% metabolic stability in an assay with rat liver microsomes, possesses the best thermodynamic solubility (22 microg/ml at pH 7.4)
1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-6-carboxylic acid
-
40% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 7 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-5-carboxylic acid
-
reveals the highest cPLA2a inhibitory potency, is 7fold more active than the lead 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid, is the metabolically most stable compound in an assay with rat liver microsomes (64% stability). Thermodynamic solubility is less than 1 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-6-carboxylic acid
-
36% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 5 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid
-
is 7fold less active than 1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-5-carboxylic acid, is the metabolically most stable compound in an assay with rat liver microsomes (65% stability). Thermodynamic solubility is less than 1 microg/ml at pH 7.4
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-sulfonamide
-
inhibits isozyme cPLA2alpha
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-6-carboxylic acid
-
39% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is less than 1 microg/ml at pH 7.4
1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-3-(methoxycarbonyl)-1H-indole-5-carboxylic acid
-
-
1-[5-(morpholine-4-carbonyl)indol-1-yl]-3-(4-octylphenoxy)propan-2-one
-
inhibits isozyme cPLA2alpha
2,2'-biphenyl-3,4'-diylbis(4H-chromen-4-one)
-, P47712
slight inhibition
2,2'-biphenyl-4,4'-diylbis(4H-chromen-4-one)
-, P47712
slight inhibition
2,2'-diphenyl-4H,4'H-6,6'-bichromene-4,4'-dione
-, P47712
slight inhibition
2,4,6-trihydroxy acetophenone
-
potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview
2,4-dihydroxy acetophenone
-
binding structure, overview
2,6-dihydroxy acetophenone
-
binding structure, overview
2-((6-bromo-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)cyclopropanecarboxylic acid
-
-
2-(1-benzyl-2-ethyl-4-methoxy-1H-benzo[g]indol-3-yl)-2-oxoacetamide
-
-
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-6,7-benzoindol-4-yloxy)acetic acid
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(methylsulfonyl)propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-chlorophenyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(2-methylphenyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(3-chlorophenyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-chlorophenyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(4-methylphenyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[(trifluoromethyl)sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-(2-methylpropyl)-1H-indol-4-yl]oxy)-N-[[2-(trifluoromethyl)phenyl]sulfonyl]propanamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-benzo[g]indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
-
2-([3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl]oxy)-N-(phenylsulfonyl)acetamide
-
-
2-mercaptoethanol
-
-
2-mercaptoethanol
-
-
2-nitrobenzenesulfonyl fluoride
Bothrops spp.
-
BthTX-I: myotoxic activity reduced to 75% and the cytotoxic activity reduced to 76%
2-oxo-N-(4-oxooctyl)hexadecanamide
-
-
2-tetradecanoylaminohexanol-1-phosphocholine
-
competitive inhibition, R-enantiomer is a more potent inhibitor
2-tetradecanoylaminohexanol-1-phosphoethanolamine
-
competitive inhibition, R-enantiomer is a more potent inhibitor
-
2-tetradecanoylaminohexanol-1-phosphoglycerol
-
competitive inhibition, R-enantiomer is a more potent inhibitor
-
2-[1-benzyl-2-(2-methylpropyl)-4-(2-oxopropoxy)-1H-indol-3-yl]-2-oxoacetamide
-
-
2-[1-benzyl-4-(2-oxopropoxy)-2-propyl-1H-indol-3-yl]-2-oxoacetamide
-
-
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-(2-oxopropoxy)indolizin-1-yl]-2-oxoacetamide
-
-
2-[3-(biphenyl-2-ylmethyl)-2-ethyl-8-methoxyindolizin-1-yl]-2-oxoacetamide
-
-
25-O-acetyl-petrosaspongiolide M
-
an anti-inflammatory marine natural product
3,3'-[[2-(pentyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one)
-
-
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one)
-
-
3,3'-[[2-(tetradecyloxy)propane-1,3-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one)
-
-
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylethane-2,1-diyl)]bis(1,2,4-oxadiazol-5(4H)-one)
-
-
3,3'-[[3-(tetradecyloxy)propane-1,2-diyl]bis(oxybenzene-4,1-diylmethanediyl)]bis(1,2,4-oxadiazol-5(4H)-one)
-
-
3,4-Dichloroisocoumarin
-
-
3,4-Dichloroisocoumarin
-
-
3,5-Dibromosalicylate
-
inhibition below the normal cutoff pressure of PLA2
3,5-diiodosalicylate
-
inhibition below the normal cutoff pressure of PLA2
3-(((2E)-4-(7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
3-(1-benzyl-2,5-dimethylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
18% inhibition at 0.033 mM
3-(1-[3-(4-octylphenoxy)-2-oxopropyl]indol-5-yl)-4,5-dihydro-1,2,4-oxadiazol-5-one
-
inhibits isozyme cPLA2alpha
3-(2,5-dimethyl-1-phenylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
40% inhibition at 0.033 mM
3-(2,5-dimethylpyrrol-3-yl)-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
35% inhibition at 0.033 mM
3-(2-[4-[(4-tetradecylpiperazin-1-yl)carbonyl]phenyl]ethyl)-1,2,4-oxadiazol-5(4H)-one
-
-
3-(3-acetamido-2-benzyl-2-ethylindolyl-5-oxy)propane phosphonic acid
-
LY311727, IC50 value of 36 nM, group IIa and V sPLA2
3-(3-[4-[(4-tetradecylpiperazin-1-yl)carbonyl]phenyl]propyl)-1,2,4-oxadiazol-5(4H)-one
-
-
3-(4-fluorophenyl)-3-(1,2,5-trimethylpyrrol-3-yl)-3H-isobenzofuran-1-one
-
36% inhibition at 0.033 mM
3-(4-fluorophenyl)-3-[1-(3-hydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3H-isobenzofuran-1-one
-
30% inhibition at 0.033 mM
3-(4-fluorophenyl)-3-[1-(4-hydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3H-isobenzofuran-1-one
-
60% inhibition at 0.033 mM
3-pyrrol-3-yl-3H-isobenzofuran-1-one
-
synthesis and inhibitory potency of derivatives, overview
3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate
-
-
3-[1-(3,4-dihydroxyphenyl)-2,5-dimethylpyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
20% inhibition at 0.033 mM
3-[1-(4-aminophenyl)-2,5-dimethylpyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
55% inhibition at 0.033 mM
3-[1-benzyl-3-(carbamoylmethyl)-2-ethylindol-5-yl]oxypropylphosphonic acid
-
LY311727, potent sPLA2 inhibitor
3-[2,5-dimethyl-1-(4-methylaminophenyl)pyrrol-3-yl]-3-(4-fluorophenyl)-3H-isobenzofuran-1-one
-
36% inhibition at 0.033 mM
3-[2-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]ethoxy]benzoate
-
-
3-[4'-(hydroxyimino-p-tolyl-methyl)-phenyl]-4-phenyl-sydnone
-
in vivo edema inducing activity, overview
3-[4'-(hydroxyimino-p-tolyl-methyl)-phenyl]-sydnone
-
in vivo edema inducing activity, overview
3-[4'-(hydroxyimino-phenyl-methyl)-phenyl]-4-phenyl-sydnone
-
in vivo edema inducing activity, overview
3-[4'-(hydroxyimino-phenyl-methyl)-phenyl]-sydnone
-
in vivo edema inducing activity, overview
3-[4-(4-hexadecylpiperazin-1-yl)benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-(4-octadecylpiperazin-1-yl)benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-(4-oxo-4H-chromen-2-yl)phenyl]-2-phenyl-4H-chromen-4-one
-, P47712
slight inhibition
3-[4-(4-tetradecylpiperazin-1-yl)benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-(tetradecyloxy)benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-docosylpiperazin-1-yl)carbonyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-hexadecylpiperazin-1-yl)carbonyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-hexadecylpiperazin-1-yl)carbonyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-hexadecylpiperazin-1-yl)methyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-hexadecylpiperazin-1-yl)methyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-icosylpiperazin-1-yl)carbonyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-octadecylpiperazin-1-yl)carbonyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-octadecylpiperazin-1-yl)carbonyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-octadecylpiperazin-1-yl)methyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-octadecylpiperazin-1-yl)methyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-tetradecylpiperazin-1-yl)carbonyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-tetradecylpiperazin-1-yl)carbonyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-tetradecylpiperazin-1-yl)methyl]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[(4-tetradecylpiperazin-1-yl)methyl]phenyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-(4-butylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-(4-methylphenoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-(decyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-(diphenylmethoxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-(pentyloxy)-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[3-ethoxy-2-(tetradecyloxy)propoxy]benzyl]-1,2,4-oxadiazol-5(4H)-one
-
-
3-[4-[hydroxyimino-(4'-n-butyl-phenyl)-methyl]-phenyl]-4-phenyl-sydnone
-
in vivo edema inducing activity, overview
3-[4-[hydroxyimino-(4'-n-butyl-phenyl)-methyl]-phenyl]-sydnone
-
in vivo edema inducing activity, overview
3-[4-[hydroxyimino-(4'-n-propyl-phenyl)-methyl]-phenyl]-4-phenylsydnone
-
in vivo edema inducing activity, overview
3-[4-[hydroxyimino-(4'-n-propyl-phenyl)-methyl]-phenyl]-sydnone
-
in vivo edema inducing activity, overview
4-(((2E)-4-(1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(1-(diphenylmethyl)-6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-2,4-dioxo-7-(1H-1,2,4-triazol-1-yl)-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-2,4-dioxo-7-(phenylthio)-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-2,4-dioxo-7-phenoxy-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-2,4-dioxo-7-thiomorpholin-4-yl-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-6-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-(4-(methoxycarbonyl)piperidin-1-yl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-(methylsulfonyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-(methylthio)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-methoxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-methyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-morpholin-4-yl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(3-(diphenylmethyl)-7-nitro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(6-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(7-amino-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(7-chloro-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-(7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-2,4-dioxo-7-(1H-1,2,4-triazol-1-yl)-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-methoxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[3-(diphenylmethyl)-7-nitro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2E)-4-[7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2Z)-4-(1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2Z)-4-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2Z)-4-(3-(diphenylmethyl)-6-fluoro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
-
-
4-(((2Z)-4-(6-bromo-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
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4-(((2Z)-4-(6-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
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4-(((2Z)-4-(7-chloro-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
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4-(((2Z)-4-(7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)oxy)benzoic acid
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4-(((E)-4-(3-benzhydryl-6-bromo-2,4-dioxo-3,4-dihydro-1(2H)-quinazolinyl)-2-butenyl)oxy)benzoic acid
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4-((5-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)pentyl)oxy)benzoic acid
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4-((6-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)hexyl)oxy)benzoic acid
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4-((6-chloro-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)benzoic acid
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4-((7-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)heptyl)oxy)benzoic acid
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4-((7-chloro-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)benzoic acid
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4-(2,4-dioxothiazolidin-5-ylidenemethyl)-N-(4-[1-(4-fluorophenyl)-3-one-1H-isobenzofuran-1-yl]-2,5-dimethyl-1-phenylpyrrol-3-ylmethyl)benzamide
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4-(2-(1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)ethoxy)benzoic acid
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4-(2-(1-benzyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)ethoxy)benzoic acid
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4-(2-(7-chloro-1-(diphenylmethyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)ethoxy)benzoic acid
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4-(2-(7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)ethoxy)benzoic acid
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4-(3-(3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)propoxy)benzoic acid
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4-(3-[1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dimethylpyrrol-1-yl)benzamide
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42% inhibition at 0.033 mM
4-(3-[1-(4-fluorophenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl]-2,5-dimethylpyrrol-1-yl)benzoic acid
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51% inhibition at 0.033 mM
4-(4-((3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)phenoxy)butanoic acid
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4-(4-(7-chloro-3-(diphenylmethyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)butoxy)benzoic acid
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4-(4-benzyloxy-phenyl)-1,1,1-trifluoro-butan-2-one
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4-(4-decyloxy-phenyl)-1,1,1-trifluoro-butan-2-one
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4-([(2E)-4-[2-(2,2-diphenylethyl)-3,5-dioxo-1,2,4-oxadiazolidin-4-yl]but-2-en-1-yl]oxy)benzoate
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4-([(2E)-4-[3-(diphenylmethyl)-2,4,6-trioxo-5-prop-2-en-1-yl-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
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4-([(2E)-4-[3-(diphenylmethyl)-5-ethyl-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
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4-([(2E)-4-[3-benzyl-5-(diphenylmethyl)-2,4,6-trioxo-1,3,5-triazinan-1-yl]but-2-en-1-yl]oxy)benzoic acid
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