EC Number   |
Application |
Reference |
|---|
   3.4.24.80 | analysis |
screening, identification, and characterization of affinity peptides, AF7p and Cy5.5-HS7, specific to MT1-MMP and application in tumor imaging, overview. Feasibility of using the subtraction biopanning strategy to screen the affinity peptide targeting MT-loop regions and HS7 is a superior probe for noninvasively imaging MT1-MMP expression in MT1-MMP-positive tumor models. Usage of HS7 in early diagnosis of tumors and in peptide-mediated drugs |
752872 |
| 3.4.24.80 | diagnostics |
MMP-14 can be a biomarker in early development of mesothelioma tumours, overview |
710375 |
| 3.4.24.80 | drug development |
dimeric MT1-MMP inhibitors might be further developed and exploited as an alternative tool to reduce cancer cell invasion |
752971 |
| 3.4.24.80 | drug development |
MMP-14 is an effective therapeutic target in therapy of mesothelioma tumours |
710375 |
| 3.4.24.80 | medicine |
complex reciprocal effects of ERK1/2 and p38 MAPK in the regulation of MT1-MMP activity, which may complicate the use of MAPK-specific inhibitors as therapeutic agents to down-regulate the biologic effects of TGF-beta1 on pericellular collagen degradation and tumor invasion |
669263 |
| 3.4.24.80 | medicine |
considering the important role of apolipoproteinE for lipid metabolism and atherosclerosis protection, MMP-14 might play an essential role for the development of hyperlipidemia and atherosclerosis as a result of degradation of apolipoprotein E |
701140 |
| 3.4.24.80 | medicine |
endothelial cell invasion of collagen I gels is MT1-MMP dependent |
668156 |
| 3.4.24.80 | medicine |
full enzymatic activity of MT1-MMP is required for a specific up-regulation of VEGF-A through an activation of Src tyrosine kinase pathways |
669211 |
| 3.4.24.80 | medicine |
mechanistic association between MT1-MMP levels and post-I/R remodeling, multiple targets for the interruption of augmented MT1-MMP activity and abundance with I/R |
668265 |
| 3.4.24.80 | medicine |
MT1-MMP and MMP gelatinase A function together in the extracellular matrix degradation or remodeling associated with metamorphosis, MT1-MMP has additional MMP gelatinase A independent roles in the development of adult longitudinal muscle in the intestine |
668208 |
