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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35analysis fusion protein of wild-type and mutant F163A GAFa domain of enzyme to Green Fluorescent Protein or Renilla luciferase for use in bioluminescence resonance energy transfer assay BRET as a biosensor of cGMP. BRET ratios of wild-type, but not mutant F163A, increase in presence of cGMP, but not cAMP 678339
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine 5 mg/kg/day sildenafil citrate administration to rats with acetic acid-induced colitis prevents lipid peroxidation, oxidant generation, cytokine production and neutrophil accumulation 712621
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine application of 10 mg vardenafil inhibits sphincter of Oddi motility in patients with suspected sphincter of Oddi dysfunction and reduces basal sphincter of Oddi pressure, without significant adverse effects 712091
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine by blocking isoform PDE5, vardenafil may be used in bladder dysfunction by ameliorating irritative lower urinary tract symptoms 679518
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine chronic treatment with a high dose (80 mg/kg) of vardenafil protects the rat bladder from bladder outlet obstruction-induced contractile dysfunction to carbachol 711555
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine enzyme inhibitors can reverse the time-dependent forgetting in the object recognition test. The efficacy of the different inhibitors is dependent on the time point of administration after acquisition. Support for a role for cGMP in early stages of memory formation and for cAMP in the late stages of memory formation 679666
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied human right ventricle 679253
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine enzyme isoform PDE5 mRNA and protein are markedly upregulated in hypertrophied myocardium. Inhibition by sildenafil or MY-5445 significantly increases contractility in hypertrophied myocardium, but not in normal. Protein kinase G is suppressed in hypertrophied myocardium 679253
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine estrogen withdrawal, but not testosterone withdrawal, is a risk factor for PDE5 inhibitor-induced flushing 711925
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.35medicine impaired vascular cGMP signalling contributes to the development of diabetic vascular and cardiac dysfunction, which can be prevented by chronic phosphodiesterase-5 inhibition 711626
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