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Literature summary for 3.1.4.35 extracted from

  • Cheon, Y.K.; Cho, Y.D.; Moon, J.H.; Im, H.H.; Jung, Y.; Lee, J.S.; Lee, M.S.; Shim, C.S.
    Effects of vardenafil, a phosphodiesterase type-5 inhibitor, on sphincter of Oddi motility in patients with suspected biliary sphincter of Oddi dysfunction (2009), Gastrointest. Endosc., 69, 1111-1116.
    View publication on PubMed
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Application

Application Comment Organism
medicine application of 10 mg vardenafil inhibits sphincter of Oddi motility in patients with suspected sphincter of Oddi dysfunction and reduces basal sphincter of Oddi pressure, without significant adverse effects Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
vardenafil vardenafil inhibits the activity of PDE-5 and results in relaxation of smooth muscle Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Homo sapiens
-
 5'-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Homo sapiens 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE-5
-
 Homo sapiens
phosphodiesterase type-5
-
 Homo sapiens